Reactome | ALG5 [endoplasmic reticulum membrane]

ALG5 [endoplasmic reticulum membrane]

Stable Identifier

R-HSA-532211

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

Synonyms

Dolichyl-phosphate beta-glucosyltransferase, ALG5_HUMAN

Locations in the PathwayBrowser

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Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Homo sapiens)
      - Synthesis of substrates in N-glycan biosythesis (Homo sapiens)
        
        Synthesis of dolichyl-phosphate-glucose (Homo sapiens)
        
        Synthesis of dolichyl-phosphate-glucose (Homo sapiens)
        
        ALG5 [endoplasmic reticulum membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9Y673 ALG5

Gene Names

ALG5, HSPC149

Chain

chain:1-324

Reference Genes

BioGPS Gene:29880 ALG5

COSMIC (genes):ALG5 ALG5

CTD Gene:29880 ALG5

dbSNP Gene:29880 ALG5

ENSEMBL:ENSG00000120697 ALG5

HGNC:20266 ALG5

KEGG:hsa:29880 ALG5

Monarch:29880 ALG5

NCBI Gene:29880 ALG5

OMIM:604565 ALG5

UCSC:Q9Y673 ALG5

Reference Transcript

Other Identifiers

11757588_a_at

16778166

218203_PM_at

218203_at

29880

3509886

3509887

3509888

3509889

3509890

3509891

3509892

3509893

3509894

3509895

3509898

3509899

3509900

3509901

3509902

3509903

3509904

3509905

3509907

3509908

3509909

57913_s_at

68207_at

73393_at

7971027

A_23_P151436

GE81824

GE85145

GO:0003824

GO:0004581

GO:0005515

GO:0005783

GO:0005789

GO:0006486

GO:0006487

GO:0006488

GO:0006629

GO:0007368

GO:0016020

GO:0016740

GO:0016757

GO:0018279

GO:0043226

GO:0098556

GO:1901135

HMNXSV003008591

ILMN_1664449

PH_hs_0029789

PH_hs_0036398

TC13000570.hg

g9665250_3p_s_at

Inferred To

wol [endoplasmic reticulum membrane] (Drosophila melanogaster)

Alg5 [endoplasmic reticulum membrane] (Mus musculus)

alg5 [endoplasmic reticulum membrane] (Danio rerio)

alg5 [endoplasmic reticulum membrane] (Dictyostelium discoideum)

alg5 [endoplasmic reticulum membrane] (Schizosaccharomyces pombe)

alg5 [endoplasmic reticulum membrane] (Xenopus tropicalis)

ALG5 [endoplasmic reticulum membrane] (Bos taurus)

ALG5 [endoplasmic reticulum membrane] (Canis familiaris)

ALG5 [endoplasmic reticulum membrane] (Gallus gallus)

ALG5 [endoplasmic reticulum membrane] (Rattus norvegicus)

ALG5 [endoplasmic reticulum membrane] (Saccharomyces cerevisiae)

ALG5 [endoplasmic reticulum membrane] (Sus scrofa)

algn-5 [endoplasmic reticulum membrane] (Caenorhabditis elegans)

Cross References

ENSEMBL

ENST00000239891, ENSP00000390533, ENSP00000239891, ENST00000443765

OpenTargets

ENSG00000120697

HPA

ENSG00000120697-ALG5

PRO

Q9Y673

Pharos - Targets

Q9Y673

GlyGen

Q9Y673

Orphanet

ALG5

HMDB Protein

HMDBP00981

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P0DTC3 3a	9	O-glycosyl 3a [virion membrane] (R-COV-9694395) O-glycosyl 3a [endocytic vesicle membrane] (R-COV-9694729) O-glycosyl 3a [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9694386) GalNAc-O-3a [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9694658) 3a [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9694716) 3a [endoplasmic reticulum lumen] (R-COV-9694584) O-glycosyl 3a [endolysosome membrane] (R-COV-9754541) O-glycosyl 3a [plasma membrane] (R-COV-9694433) O-glycosyl 3a [extracellular region] (R-COV-9694387)	0.738	4
UniProt:P0DTD8 NS7B			0.643	3

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