Reactome | GFPT2 [cytosol]

GFPT2 [cytosol]

Stable Identifier

R-HSA-532208

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Glucosamine--fructose-6-phosphate aminotransferase (isomerizing) 2

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Homo sapiens)
      - Synthesis of substrates in N-glycan biosythesis (Homo sapiens)
        
        Synthesis of UDP-N-acetyl-glucosamine (Homo sapiens)
        
        GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P (Homo sapiens)
        
        GFPT1,2 [cytosol] (Homo sapiens)
        
        GFPT2 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:O94808 GFPT2

Gene Names

GFPT2

Chain

initiator methionine:1, chain:2-682

Reference Genes

BioGPS Gene:9945 GFPT2

COSMIC (genes):GFPT2 GFPT2

CTD Gene:9945 GFPT2

dbSNP Gene:9945 GFPT2

ENSEMBL:ENSG00000131459 GFPT2

HGNC:4242 GFPT2

KEGG:hsa:9945 GFPT2

Monarch:9945 GFPT2

NCBI Gene:9945 GFPT2

OMIM:603865 GFPT2

UCSC:O94808 GFPT2

Reference Transcript

RefSeq:NM_005110.4 GFPT2

Other Identifiers

11721133_at

11721134_at

17003924

205100_PM_at

205100_at

2890661

2890662

2890663

2890664

2890665

2890667

2890668

2890669

2890670

2890671

2890672

2890673

2890675

2890676

2890677

2890678

2890679

2890680

2890682

2890684

2890686

2890687

2890688

2890689

2890690

2890692

2890693

2890694

2890695

2890702

2890703

2890704

39640_at

8116418

9945

A_23_P144916

GE53420

GO:0004360

GO:0005515

GO:0005829

GO:0006002

GO:0006047

GO:0006048

GO:0006112

GO:0006486

GO:0006487

GO:0008483

GO:0016740

GO:0046349

GO:0055086

GO:0097367

GO:1901135

GO:1901137

GO:1990830

HMNXSV003044577

ILMN_1709674

PH_hs_0002603

TC05002146.hg

g4826741_3p_at

Participates

as a member of

GFPT1,2 [cytosol] (Homo sapiens)

Inferred To

gfpt2 [cytosol] (Danio rerio)

gfpt2 [cytosol] (Xenopus tropicalis)

Gfpt2 [cytosol] (Mus musculus)

Gfpt2 [cytosol] (Rattus norvegicus)

GFPT2 [cytosol] (Bos taurus)

GFPT2 [cytosol] (Canis familiaris)

GFPT2 [cytosol] (Dictyostelium discoideum)

GFPT2 [cytosol] (Gallus gallus)

GFPT2 [cytosol] (Plasmodium falciparum)

GFPT2 [cytosol] (Schizosaccharomyces pombe)

GFPT2 [cytosol] (Sus scrofa)

GFA1 [cytosol] (Saccharomyces cerevisiae)

Gfat2 [cytosol] (Drosophila melanogaster)

gfat-1 [cytosol] (Caenorhabditis elegans)

Cross References

RefSeq

NP_005101.1

ENSEMBL

ENSP00000253778, ENSG00000131459, ENST00000253778

OpenTargets

ENSG00000131459

GeneCards

GFPT2

HPA

ENSG00000131459-GFPT2

PRO

O94808

Pharos - Targets

O94808

HMDB Protein

HMDBP00214

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q06210 GFPT1	6	GFPT1 [cytosol] (R-HSA-532216) GFPT1 W240* [cytosol] (R-HSA-4341665) GFPT1 D348Y [cytosol] (R-HSA-4341671) GFPT1 R111C [cytosol] (R-HSA-4341655) GFPT1 T147Qfs*61 [cytosol] (R-HSA-4341657) GFPT1 T15A [cytosol] (R-HSA-4341662)	0.623	3
UniProt:Q07954 LRP1	2	LRP1 [plasma membrane] (R-HSA-1454844) LRP1 [endocytic vesicle membrane] (R-HSA-2230981)	0.527	2
UniProt:Q9NUX5 POT1	1	POT1 [nucleoplasm] (R-HSA-174890)	0.508	2

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