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CYP2D6 [endoplasmic reticulum membrane]
Stable Identifier
R-HSA-52679
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane
Synonyms
Cytochrome P450 2D6 , CYPIID6, P450-DB1, Debrisoquine 4-hydroxylase
Locations in the PathwayBrowser
Expand all
Drug ADME (Homo sapiens)
Aspirin ADME (Homo sapiens)
CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA (Homo sapiens)
CYP2,3 cytochromes [endoplasmic reticulum membrane] (Homo sapiens)
CYP2D6 [endoplasmic reticulum membrane] (Homo sapiens)
CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA (Homo sapiens)
CYP2,3 cytochromes [endoplasmic reticulum membrane] (Homo sapiens)
CYP2D6 [endoplasmic reticulum membrane] (Homo sapiens)
Metabolism (Homo sapiens)
Biological oxidations (Homo sapiens)
Phase I - Functionalization of compounds (Homo sapiens)
Cytochrome P450 - arranged by substrate type (Homo sapiens)
Fatty acids (Homo sapiens)
CYP2J2 oxidises ARA (Homo sapiens)
Cytochrome P450 (CYP2J2 based) [endoplasmic reticulum membrane] (Homo sapiens)
CYP2D6 [endoplasmic reticulum membrane] (Homo sapiens)
Miscellaneous substrates (Homo sapiens)
CYP2W1 oxidises INDOL (Homo sapiens)
Cytochrome P450 (CYP2W1 based) [endoplasmic reticulum membrane] (Homo sapiens)
CYP2D6 [endoplasmic reticulum membrane] (Homo sapiens)
Xenobiotics (Homo sapiens)
CYP2C19 5-hydroxylates omeprazole (Homo sapiens)
Cytochrome P450 (CYP2C19 based) [endoplasmic reticulum membrane] (Homo sapiens)
CYP2D6 [endoplasmic reticulum membrane] (Homo sapiens)
CYP2C8 inactivates paclitaxel by 6alpha-hydroxylation (Homo sapiens)
Cytochrome P450 (CYP2C8 based) [endoplasmic reticulum membrane] (Homo sapiens)
CYP2D6 [endoplasmic reticulum membrane] (Homo sapiens)
CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation (Homo sapiens)
Cytochrome P450 (CYP2C9 based) [endoplasmic reticulum membrane] (Homo sapiens)
CYP2D6 [endoplasmic reticulum membrane] (Homo sapiens)
CYP2D6 4-hydroxylates debrisoquine (Homo sapiens)
Cytochrome P450 (CYP2D6 based) [endoplasmic reticulum membrane] (Homo sapiens)
CYP2D6 [endoplasmic reticulum membrane] (Homo sapiens)
CYP2E1 reactions (Homo sapiens)
Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI) (Homo sapiens)
Cytochrome P450 (CYP2E1 based) [endoplasmic reticulum membrane] (Homo sapiens)
CYP2D6 [endoplasmic reticulum membrane] (Homo sapiens)
Benzene is hydroxylated to phenol (Homo sapiens)
Cytochrome P450 (CYP2E1 based) [endoplasmic reticulum membrane] (Homo sapiens)
CYP2D6 [endoplasmic reticulum membrane] (Homo sapiens)
Dehalogenation of carbon tetrachloride to form a free radical (Homo sapiens)
Cytochrome P450 (CYP2E1 based) [endoplasmic reticulum membrane] (Homo sapiens)
CYP2D6 [endoplasmic reticulum membrane] (Homo sapiens)
Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and hydrogen bromide (Homo sapiens)
Cytochrome P450 (CYP2E1 based) [endoplasmic reticulum membrane] (Homo sapiens)
CYP2D6 [endoplasmic reticulum membrane] (Homo sapiens)
MEOS oxidizes ethanol to acetaldehyde (Homo sapiens)
Cytochrome P450 (CYP2E1 based) [endoplasmic reticulum membrane] (Homo sapiens)
CYP2D6 [endoplasmic reticulum membrane] (Homo sapiens)
Vinyl chloride is oxidized to 2-Chloroethylene oxide (Homo sapiens)
Cytochrome P450 (CYP2E1 based) [endoplasmic reticulum membrane] (Homo sapiens)
CYP2D6 [endoplasmic reticulum membrane] (Homo sapiens)
O-atom dealkylation of dextromethorphan (Homo sapiens)
Cytochrome P450 (CYP2D6 based) [endoplasmic reticulum membrane] (Homo sapiens)
CYP2D6 [endoplasmic reticulum membrane] (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Biosynthesis of specialized proresolving mediators (SPMs) (Homo sapiens)
Biosynthesis of DHA-derived SPMs (Homo sapiens)
Biosynthesis of maresins (Homo sapiens)
Biosynthesis of maresin-like SPMs (Homo sapiens)
CYPs hydroxylate DHA to 14(R)-HDHA (Homo sapiens)
CYP1A2,2C8,2C9,2D6,2E1,3A4 [endoplasmic reticulum membrane] (Homo sapiens)
CYP2D6 [endoplasmic reticulum membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P10635 CYP2D6
Gene Names
CYP2D6, CYP2DL1
Chain
chain:1-497
Reference Genes
BioGPS Gene:1565 CYP2D6
COSMIC (genes):CYP2D6 CYP2D6
CTD Gene:1565 CYP2D6
dbSNP Gene:1565 CYP2D6
ENSEMBL:ENSG00000100197 CYP2D6
HGNC:2625 CYP2D6
KEGG:hsa:1565 CYP2D6
Monarch:1565 CYP2D6
NCBI Gene:1565 CYP2D6
OMIM:124030 CYP2D6
UCSC:P10635 CYP2D6
Reference Transcript
RefSeq:NM_001025161.2 CYP2D6
RefSeq:NM_000106.5 CYP2D6
Other Identifiers
11733907_s_at
11733908_x_at
1436_at
1565
16935560
207498_3p_s_at
207498_PM_s_at
207498_s_at
215809_PM_at
215809_at
38507_at
3962295
3962298
3962299
3962303
3962306
3962308
3962309
3962312
3962313
3962318
3962321
3962326
8076424
8180391
A_23_P143734
A_23_P155123
GE61084
GO:0003824
GO:0004497
GO:0005506
GO:0005737
GO:0005739
GO:0005783
GO:0005789
GO:0006629
GO:0006631
GO:0006805
GO:0008202
GO:0008203
GO:0008210
GO:0009804
GO:0009820
GO:0009822
GO:0016020
GO:0016098
GO:0016491
GO:0016705
GO:0016712
GO:0019369
GO:0020037
GO:0033076
GO:0042178
GO:0042572
GO:0042759
GO:0043226
GO:0043231
GO:0046872
GO:0051100
GO:0062187
GO:0062188
GO:0062189
GO:0070330
GO:0070989
GO:0090350
HMNXSV003002247
HMNXSV003005926
ILMN_1740648
ILMN_2383124
PH_hs_0038027
TC22001361.hg
TC22001430.hg
X07618_s_at
X16866_at
g4503222_3p_s_at
Participates
as a member of
CYP1A2,2C8,2C9,2D6,2E1,3A4 [endoplasmic reticulum membrane] (Homo sapiens)
CYP2,3 cytochromes [endoplasmic reticulum membrane] (Homo sapiens)
Cytochrome P450 (CYP2D6 based) [endoplasmic reticulum membrane] (Homo sapiens)
as a candidate of
Cytochrome P450 (CYP2C19 based) [endoplasmic reticulum membrane] (Homo sapiens)
Cytochrome P450 (CYP2C9 based) [endoplasmic reticulum membrane] (Homo sapiens)
Cytochrome P450 (CYP2C8 based) [endoplasmic reticulum membrane] (Homo sapiens)
Cytochrome P450 (CYP2J2 based) [endoplasmic reticulum membrane] (Homo sapiens)
Cytochrome P450 (CYP2W1 based) [endoplasmic reticulum membrane] (Homo sapiens)
Cytochrome P450 (CYP2E1 based) [endoplasmic reticulum membrane] (Homo sapiens)
Inferred To
cyp2x8 [endoplasmic reticulum membrane]
(Danio rerio)
cyp-33e3 [endoplasmic reticulum membrane]
(Caenorhabditis elegans)
CYP2D6 [endoplasmic reticulum membrane]
(Bos taurus)
CYP2D6 [endoplasmic reticulum membrane]
(Caenorhabditis elegans)
CYP2D6 [endoplasmic reticulum membrane]
(Danio rerio)
CYP2D6 [endoplasmic reticulum membrane]
(Dictyostelium discoideum)
CYP2D6 [endoplasmic reticulum membrane]
(Drosophila melanogaster)
CYP2D6 [endoplasmic reticulum membrane]
(Gallus gallus)
CYP2D6 [endoplasmic reticulum membrane]
(Mus musculus)
CYP2D6 [endoplasmic reticulum membrane]
(Rattus norvegicus)
CYP2D6 [endoplasmic reticulum membrane]
(Sus scrofa)
CYP2D6 [endoplasmic reticulum membrane]
(Xenopus tropicalis)
cyp-33c12 [endoplasmic reticulum membrane]
(Caenorhabditis elegans)
daf-9 [endoplasmic reticulum membrane]
(Caenorhabditis elegans)
Homologues of CYP2D6 [endoplasmic reticulum membrane]
(Caenorhabditis elegans)
Homologues of CYP2D6 [endoplasmic reticulum membrane]
(Danio rerio)
Homologues of CYP2D6 [endoplasmic reticulum membrane]
(Dictyostelium discoideum)
Homologues of CYP2D6 [endoplasmic reticulum membrane]
(Drosophila melanogaster)
CYP2D15 [endoplasmic reticulum membrane]
(Canis familiaris)
Cross References
ZINC - World Drugs
CP2D6_HUMAN
Guide to Pharmacology - Targets
1329
OpenTargets
ENSG00000100197
ENSEMBL
ENST00000645361
,
ENSP00000496150
,
ENSP00000351927
,
ENSP00000483677
,
ENST00000612990
,
ENST00000359033
ZINC - FDA approved
CP2D6_HUMAN
ZINC - Substances
CP2D6_HUMAN
ZINC target
P10635
ZINC - Biogenic
CP2D6_HUMAN
PRO
P10635
PDB
6CSB
,
3TDA
,
5TFU
,
6CSD
,
4WNT
,
4WNU
,
4XRZ
,
5TFT
,
4WNV
,
2F9Q
,
4XRY
,
3QM4
,
4WNW
,
3TBG
ZINC - Investigational
CP2D6_HUMAN
ZINC - Metabolites
CP2D6_HUMAN
HPA
ENSG00000100197-CYP2D6
Pharos - Targets
P10635
ZINC - Predictions - Purchasable
CP2D6_HUMAN
HMDB Protein
HMDBP01548
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