B-WICH:histone acetyltransferase acetylates histone H3 at lysine-9

Stable Identifier
Reaction [transition]
Homo sapiens
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Histone acetyltransferases recruited by the B‑WICH complex acetylate histone H3 at lysine‑9. Knockdown of the BAZ1B (WSTF) and MYOIC components of B‑WICH cause a loss of histone acetyltransferases KAT2B (PCAF), KAT2A (GCN5), and EP300 (p300) and a reduction of acetylated histone H3. Knockdown of KAT2B (PCAF) causes a reduction in acetylation of histone H3 at lysine‑9, leading to reduced rRNA synthesis levels (Sarshad et al. 2013, Shen et al. 2013).

Literature References
PubMed ID Title Journal Year
23667505 The chromatin remodeling factor CSB recruits histone acetyltransferase PCAF to rRNA gene promoters in active state for transcription initiation

Lyu, G, Zhou, T, Zhu, Q, Shen, M, Zhang, F, Gao, Q, Ling, T, Zong, L, Xie, W, Tao, W

PLoS ONE 2013
23555303 Nuclear myosin 1c facilitates the chromatin modifications required to activate rRNA gene transcription and cell cycle progression

Böhm, S, Sarshad, A, Percipalle, P, Fomproix, N, Sadeghifar, F, Vintermist, A, Louvet, E, Al-Muzzaini, B, Östlund, AK, Mori, R

PLoS Genet. 2013
Catalyst Activity

histone acetyltransferase activity of B-WICH:rDNA Promoter:KAT2B:KAT2A:EP300 [nucleoplasm]

Orthologous Events
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