Reactome | B-WICH:histone acetyltransferase acetylates histone H3 at lysine-9

B-WICH:histone acetyltransferase acetylates histone H3 at lysine-9

Stable Identifier

R-HSA-5250938

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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B-WICH:histone acetyltransferase acetylates histone H3 at lysine-9

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Histone acetyltransferases recruited by the B‑WICH complex acetylate histone H3 at lysine‑9. Knockdown of the BAZ1B (WSTF) and MYOIC components of B‑WICH cause a loss of histone acetyltransferases KAT2B (PCAF), KAT2A (GCN5), and EP300 (p300) and a reduction of acetylated histone H3. Knockdown of KAT2B (PCAF) causes a reduction in acetylation of histone H3 at lysine‑9, leading to reduced rRNA synthesis levels (Sarshad et al. 2013, Shen et al. 2013).

Literature References

PubMed ID	Title	Journal	Year
23667505	The chromatin remodeling factor CSB recruits histone acetyltransferase PCAF to rRNA gene promoters in active state for transcription initiation Shen, M, Zhou, T, Xie, W, Ling, T, Zhu, Q, Zong, L, Lyu, G, Gao, Q, Zhang, F, Tao, W	PLoS ONE	2013
23555303	Nuclear myosin 1c facilitates the chromatin modifications required to activate rRNA gene transcription and cell cycle progression Sarshad, A, Sadeghifar, F, Louvet, E, Mori, R, Böhm, S, Al-Muzzaini, B, Vintermist, A, Fomproix, N, Östlund, AK, Percipalle, P	PLoS Genet.	2013