VEGF induces CDC42 activation by unknown mechanism

Stable Identifier
R-HSA-5218829
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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VEGF induces CDC42 activation by unknown mechanism
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CDC42 is involved in the formation of filopodia with potential functions in guidance and migration in response to a VEGF gradient. CDC42 is activated downstream of VEGFR2 and involved in the formation of stress fibres by contributing to the activation of the p38 pathway. The activation of CDC42 may rely on FYN activity but the precise mechanism that leads to activation is not known (Lamalice et al. 2004, 2006).
Literature References
PubMed ID Title Journal Year
14724572 Phosphorylation of tyrosine 1214 on VEGFR2 is required for VEGF-induced activation of Cdc42 upstream of SAPK2/p38

Houle, F, Jourdan, G, Huot, J, Lamalice, L

Oncogene 2004
Participants
Input
Output
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as an event of
Catalyst Activity

guanyl-nucleotide exchange factor activity of Unknown GEF [cytosol]

Physical Entity
Unknown GEF [cytosol] (Homo sapiens)
Activity
guanyl-nucleotide exchange factor activity (GO:0005085)
Authored
Garapati, P V  (2013-08-30)
Reviewed
Ballmer-Hofer, K  (2014-05-12)
Welsh, M  (2014-05-12)
Berger, P  (2014-05-12)
Created
Garapati, P V  (2013-12-19)
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