VEGFA-VEGFR2 Pathway

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R-HSA-4420097
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Pathway
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Homo sapiens
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Angiogenesis is the formation of new blood vessels from preexisting vasculature. One of the most important proangiogenic factors is vascular endothelial growth factor (VEGF). VEGF exerts its biologic effect through interaction with transmembrane tyrosine kinase receptors VEGFR, selectively expressed on vascular endothelial cells. VEGFA signaling through VEGFR2 is the major pathway that activates angiogenesis by inducing the proliferation, survival, sprouting and migration of endothelial cells (ECs), and also by increasing endothelial permeability (Lohela et al. 2009, Shibuya & Claesson-Welsh 2006, Claesson-Welsh & Welsh, 2013). The critical role of VEGFR2 in vascular development is highlighted by the fact that VEGFR2-/- mice die at E8.5-9.5 due to defective development of blood islands, endothelial cells and haematopoietic cells (Shalaby et al. 1995).

Literature References
PubMed ID Title Journal Year
17344076 Vascular endothelial growth factor family of ligands and receptors: review

Makarem, JA, Shamseddine, AI, Otrock, ZK

Blood Cells Mol. Dis. 2007
19230644 VEGFs and receptors involved in angiogenesis versus lymphangiogenesis

Lohela, M, Alitalo, K, Tammela, T, Bry, M

Curr. Opin. Cell Biol. 2009
16633338 VEGF receptor signalling - in control of vascular function

Dimberg, A, Kreuger, J, Olsson, AK, Claesson-Welsh, L

Nat Rev Mol Cell Biol 2006
13678960 VEGF-receptor signal transduction

Matsumoto, T, Cross, MJ, Dixelius, J, Claesson-Welsh, L

Trends Biochem Sci 2003
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