SRC-1 binds p-Y397-PTK2

Stable Identifier
R-HSA-5218645
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Autophosphorylation of Y397 on FAK1 provides a high affinity binding site for the Src homology 2 (SH2) domain of Src family kinases (SFKs) allowing their recruitment, activation and subsequent transphosphorylation of FAK1 at additional sites (Calalb et al. 1995).

Literature References
PubMed ID Title Journal Year
7509446 Autophosphorylation of the focal adhesion kinase, pp125FAK, directs SH2-dependent binding of pp60src

Schaller, MD, Hildebrand, JD, Shannon, JD, Fox, JW, Vines, RR, Parsons, JT

Mol Cell Biol 1994
Participants
Participant Of
Orthologous Events
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Reviewed
Created