Reactome | SRC-1 binds p-Y397-PTK2

SRC-1 binds p-Y397-PTK2

Stable Identifier

R-HSA-5218645

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

ReviewStatus

5/5

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Autophosphorylation of Y397 on FAK1 provides a high affinity binding site for the Src homology 2 (SH2) domain of Src family kinases (SFKs) allowing their recruitment, activation and subsequent transphosphorylation of FAK1 at additional sites (Calalb et al. 1995).

Literature References

PubMed ID	Title	Journal	Year
7509446	Autophosphorylation of the focal adhesion kinase, pp125FAK, directs SH2-dependent binding of pp60src Hildebrand, JD, Shannon, JD, Fox, JW, Schaller, MD, Parsons, JT, Vines, RR	Mol Cell Biol	1994