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SRC-1 binds p-Y397-PTK2
Stable Identifier
R-HSA-5218645
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
,
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
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Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by VEGF (Homo sapiens)
VEGFA-VEGFR2 Pathway (Homo sapiens)
SRC-1 binds p-Y397-PTK2 (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Autophosphorylation of Y397 on FAK1 provides a high affinity binding site for the Src homology 2 (SH2) domain of Src family kinases (SFKs) allowing their recruitment, activation and subsequent transphosphorylation of FAK1 at additional sites (Calalb et al. 1995).
Literature References
PubMed ID
Title
Journal
Year
7509446
Autophosphorylation of the focal adhesion kinase, pp125FAK, directs SH2-dependent binding of pp60src
Hildebrand, JD
,
Shannon, JD
,
Fox, JW
,
Schaller, MD
,
Parsons, JT
,
Vines, RR
Mol Cell Biol
1994
Participants
Input
SRC-1 [cytosol]
(Homo sapiens)
VEGFA:p-6Y-VEGFR2:p-SHB:p-Y397-PTK2 [plasma membrane]
(Homo sapiens)
Output
VEGFA:p-6Y-VEGFR2:p-SHB:p-Y397-PTK2:SRC-1 [plasma membrane]
(Homo sapiens)
Participates
as an event of
VEGFA-VEGFR2 Pathway (Homo sapiens)
Orthologous Events
SRC-1 binds p-Y397-PTK2 (Bos taurus)
SRC-1 binds p-Y397-PTK2 (Canis familiaris)
SRC-1 binds p-Y397-PTK2 (Gallus gallus)
SRC-1 binds p-Y397-PTK2 (Mus musculus)
SRC-1 binds p-Y397-PTK2 (Rattus norvegicus)
SRC-1 binds p-Y397-PTK2 (Sus scrofa)
Authored
Garapati, P V (2013-08-30)
Reviewed
Ballmer-Hofer, K (2014-05-12)
Welsh, M (2014-05-12)
Berger, P (2014-05-12)
Created
Garapati, P V (2013-12-19)
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