SRC-1 binds p-Y397-PTK2

Stable Identifier
R-HSA-5218645
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
ReviewStatus
5/5
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SRC-1 binds p-Y397-PTK2
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Autophosphorylation of Y397 on FAK1 provides a high affinity binding site for the Src homology 2 (SH2) domain of Src family kinases (SFKs) allowing their recruitment, activation and subsequent transphosphorylation of FAK1 at additional sites (Calalb et al. 1995).
Literature References
PubMed ID Title Journal Year
7509446 Autophosphorylation of the focal adhesion kinase, pp125FAK, directs SH2-dependent binding of pp60src

Hildebrand, JD, Shannon, JD, Fox, JW, Schaller, MD, Parsons, JT, Vines, RR

Mol Cell Biol 1994
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Orthologous Events
SRC-1 binds p-Y397-PTK2 (Bos taurus)
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SRC-1 binds p-Y397-PTK2 (Gallus gallus)
SRC-1 binds p-Y397-PTK2 (Mus musculus)
SRC-1 binds p-Y397-PTK2 (Rattus norvegicus)
SRC-1 binds p-Y397-PTK2 (Sus scrofa)
Authored
Garapati, P V  (2013-08-30)
Reviewed
Ballmer-Hofer, K  (2014-05-12)
Welsh, M  (2014-05-12)
Berger, P  (2014-05-12)
Created
Garapati, P V  (2013-12-19)
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