Reactome | SYT8 [plasma membrane]

SYT8 [plasma membrane]

Stable Identifier

R-HSA-5216119

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Synaptotagmin-8, SYT8_HUMAN

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - Clathrin-mediated endocytosis (Homo sapiens)
    - BAR domain proteins recruit dynamin (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        STON2,1:SYT dimers [plasma membrane] (Homo sapiens)
        
        SYT dimers [plasma membrane] (Homo sapiens)
        
        SYT8 dimer [plasma membrane] (Homo sapiens)
        
        SYT8 [plasma membrane] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        STON2,1:SYT dimers [plasma membrane] (Homo sapiens)
        
        SYT dimers [plasma membrane] (Homo sapiens)
        
        SYT8 dimer [plasma membrane] (Homo sapiens)
        
        SYT8 [plasma membrane] (Homo sapiens)
    - CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Homo sapiens)
      - CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        STON2,1:SYT dimers [plasma membrane] (Homo sapiens)
        
        SYT dimers [plasma membrane] (Homo sapiens)
        
        SYT8 dimer [plasma membrane] (Homo sapiens)
        
        SYT8 [plasma membrane] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        STON2,1:SYT dimers [plasma membrane] (Homo sapiens)
        
        SYT dimers [plasma membrane] (Homo sapiens)
        
        SYT8 dimer [plasma membrane] (Homo sapiens)
        
        SYT8 [plasma membrane] (Homo sapiens)
    - Cargo recognition for clathrin-mediated endocytosis (Homo sapiens)
      - STON2 binds SYT proteins (Homo sapiens)
        
        STON2,1:SYT dimers [plasma membrane] (Homo sapiens)
        
        SYT dimers [plasma membrane] (Homo sapiens)
        
        SYT8 dimer [plasma membrane] (Homo sapiens)
        
        SYT8 [plasma membrane] (Homo sapiens)
        
        SYT dimers [plasma membrane] (Homo sapiens)
        
        SYT8 dimer [plasma membrane] (Homo sapiens)
        
        SYT8 [plasma membrane] (Homo sapiens)
    - Clathrin recruits PIK3C2A (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        STON2,1:SYT dimers [plasma membrane] (Homo sapiens)
        
        SYT dimers [plasma membrane] (Homo sapiens)
        
        SYT8 dimer [plasma membrane] (Homo sapiens)
        
        SYT8 [plasma membrane] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        STON2,1:SYT dimers [plasma membrane] (Homo sapiens)
        
        SYT dimers [plasma membrane] (Homo sapiens)
        
        SYT8 dimer [plasma membrane] (Homo sapiens)
        
        SYT8 [plasma membrane] (Homo sapiens)
    - Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        STON2,1:SYT dimers [plasma membrane] (Homo sapiens)
        
        SYT dimers [plasma membrane] (Homo sapiens)
        
        SYT8 dimer [plasma membrane] (Homo sapiens)
        
        SYT8 [plasma membrane] (Homo sapiens)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        STON2,1:SYT dimers [plasma membrane] (Homo sapiens)
        
        SYT dimers [plasma membrane] (Homo sapiens)
        
        SYT8 dimer [plasma membrane] (Homo sapiens)
        
        SYT8 [plasma membrane] (Homo sapiens)
    - Endophilins recruit synaptojanins to the clathrin-coated pit (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        STON2,1:SYT dimers [plasma membrane] (Homo sapiens)
        
        SYT dimers [plasma membrane] (Homo sapiens)
        
        SYT8 dimer [plasma membrane] (Homo sapiens)
        
        SYT8 [plasma membrane] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        STON2,1:SYT dimers [plasma membrane] (Homo sapiens)
        
        SYT dimers [plasma membrane] (Homo sapiens)
        
        SYT8 dimer [plasma membrane] (Homo sapiens)
        
        SYT8 [plasma membrane] (Homo sapiens)
    - F- and N- BAR domain proteins bind the clathrin-coated pit (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        STON2,1:SYT dimers [plasma membrane] (Homo sapiens)
        
        SYT dimers [plasma membrane] (Homo sapiens)
        
        SYT8 dimer [plasma membrane] (Homo sapiens)
        
        SYT8 [plasma membrane] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        STON2,1:SYT dimers [plasma membrane] (Homo sapiens)
        
        SYT dimers [plasma membrane] (Homo sapiens)
        
        SYT8 dimer [plasma membrane] (Homo sapiens)
        
        SYT8 [plasma membrane] (Homo sapiens)
    - SNX9 recruits components of the actin polymerizing machinery (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        STON2,1:SYT dimers [plasma membrane] (Homo sapiens)
        
        SYT dimers [plasma membrane] (Homo sapiens)
        
        SYT8 dimer [plasma membrane] (Homo sapiens)
        
        SYT8 [plasma membrane] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        STON2,1:SYT dimers [plasma membrane] (Homo sapiens)
        
        SYT dimers [plasma membrane] (Homo sapiens)
        
        SYT8 dimer [plasma membrane] (Homo sapiens)
        
        SYT8 [plasma membrane] (Homo sapiens)
    - SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        STON2,1:SYT dimers [plasma membrane] (Homo sapiens)
        
        SYT dimers [plasma membrane] (Homo sapiens)
        
        SYT8 dimer [plasma membrane] (Homo sapiens)
        
        SYT8 [plasma membrane] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        STON2,1:SYT dimers [plasma membrane] (Homo sapiens)
        
        SYT dimers [plasma membrane] (Homo sapiens)
        
        SYT8 dimer [plasma membrane] (Homo sapiens)
        
        SYT8 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q8NBV8 SYT8

Gene Names

SYT8

Chain

chain:1-401

Reference Genes

BioGPS Gene:90019 SYT8

COSMIC (genes):SYT8 SYT8

CTD Gene:90019 SYT8

dbSNP Gene:90019 SYT8

ENSEMBL:ENSG00000149043 SYT8

ENSEMBL:ENSG00000288149 SYT8

HGNC:19264 SYT8

KEGG Gene (Homo sapiens):90019 SYT8

Monarch:90019 SYT8

NCBI Gene:90019 SYT8

OMIM:607719 SYT8

UCSC:Q8NBV8 SYT8

Reference Transcript

RefSeq:NM_138567.4 SYT8

Other Identifiers

11755119_a_at

11760742_x_at

232802_at

3317034

3317036

3317038

3317039

3317042

3317045

3317047

3317049

3317050

3317051

3317052

3317053

3317054

3317055

55233_at

7937713

90019

A_23_P36187

GO:0000003

GO:0000149

GO:0001669

GO:0001786

GO:0003674

GO:0005509

GO:0005544

GO:0005575

GO:0005622

GO:0005737

GO:0005886

GO:0006810

GO:0006887

GO:0007267

GO:0007340

GO:0008150

GO:0008289

GO:0014059

GO:0016020

GO:0016021

GO:0016192

GO:0017156

GO:0017158

GO:0019905

GO:0030276

GO:0030424

GO:0030672

GO:0031045

GO:0031410

GO:0031982

GO:0043167

GO:0043226

GO:0048306

GO:0048488

GO:0048791

GO:0070382

GO:0071277

HMNXSV003004873

HMNXSV003023251

Hs.161031.0.S1_3p_at

ILMN_1808415

Participates

as a component of

SYT8 dimer [plasma membrane] (Homo sapiens)

Other forms of this molecule

SYT8 [clathrin-coated endocytic vesicle membrane]

Inferred To

Homologues of SYT8 [plasma membrane] (Caenorhabditis elegans)

Syt8 [plasma membrane] (Mus musculus)

Syt8 [plasma membrane] (Rattus norvegicus)

Syt1 [plasma membrane] (Drosophila melanogaster)

snt-2 [plasma membrane] (Caenorhabditis elegans)

sue-1 [plasma membrane] (Caenorhabditis elegans)

SYT8 [plasma membrane] (Caenorhabditis elegans)

SYT8 [plasma membrane] (Canis familiaris)

SYT8 [plasma membrane] (Gallus gallus)

SYT8 [plasma membrane] (Sus scrofa)

snt-3 [plasma membrane] (Caenorhabditis elegans)

snt-5 [plasma membrane] (Caenorhabditis elegans)

snt-1 [plasma membrane] (Caenorhabditis elegans)

Cross References

RefSeq

NP_612634.3

OpenTargets

ENSG00000149043

HPA

ENSG00000149043-SYT8

GeneCards

Q8NBV8

Ensembl

ENSP00000500064, ENST00000672195, ENST00000381968, ENSG00000149043, ENSP00000371394, ENSG00000288149

PRO

Q8NBV8

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