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SYT8 [plasma membrane]
Stable Identifier
R-HSA-5216119
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Synaptotagmin-8, SYT8_HUMAN
Locations in the PathwayBrowser
Expand all
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
Clathrin-mediated endocytosis (Homo sapiens)
BAR domain proteins recruit dynamin (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
STON2,1:SYT dimers [plasma membrane] (Homo sapiens)
SYT dimers [plasma membrane] (Homo sapiens)
SYT8 dimer [plasma membrane] (Homo sapiens)
SYT8 [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
STON2,1:SYT dimers [plasma membrane] (Homo sapiens)
SYT dimers [plasma membrane] (Homo sapiens)
SYT8 dimer [plasma membrane] (Homo sapiens)
SYT8 [plasma membrane] (Homo sapiens)
CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
STON2,1:SYT dimers [plasma membrane] (Homo sapiens)
SYT dimers [plasma membrane] (Homo sapiens)
SYT8 dimer [plasma membrane] (Homo sapiens)
SYT8 [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
STON2,1:SYT dimers [plasma membrane] (Homo sapiens)
SYT dimers [plasma membrane] (Homo sapiens)
SYT8 dimer [plasma membrane] (Homo sapiens)
SYT8 [plasma membrane] (Homo sapiens)
Cargo recognition for clathrin-mediated endocytosis (Homo sapiens)
STON2 binds SYT proteins (Homo sapiens)
STON2,1:SYT dimers [plasma membrane] (Homo sapiens)
SYT dimers [plasma membrane] (Homo sapiens)
SYT8 dimer [plasma membrane] (Homo sapiens)
SYT8 [plasma membrane] (Homo sapiens)
SYT dimers [plasma membrane] (Homo sapiens)
SYT8 dimer [plasma membrane] (Homo sapiens)
SYT8 [plasma membrane] (Homo sapiens)
Clathrin recruits PIK3C2A (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
STON2,1:SYT dimers [plasma membrane] (Homo sapiens)
SYT dimers [plasma membrane] (Homo sapiens)
SYT8 dimer [plasma membrane] (Homo sapiens)
SYT8 [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
STON2,1:SYT dimers [plasma membrane] (Homo sapiens)
SYT dimers [plasma membrane] (Homo sapiens)
SYT8 dimer [plasma membrane] (Homo sapiens)
SYT8 [plasma membrane] (Homo sapiens)
Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
STON2,1:SYT dimers [plasma membrane] (Homo sapiens)
SYT dimers [plasma membrane] (Homo sapiens)
SYT8 dimer [plasma membrane] (Homo sapiens)
SYT8 [plasma membrane] (Homo sapiens)
Dynamin-mediated GTP hydrolysis promotes vesicle scission (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
STON2,1:SYT dimers [plasma membrane] (Homo sapiens)
SYT dimers [plasma membrane] (Homo sapiens)
SYT8 dimer [plasma membrane] (Homo sapiens)
SYT8 [plasma membrane] (Homo sapiens)
Endophilins recruit synaptojanins to the clathrin-coated pit (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
STON2,1:SYT dimers [plasma membrane] (Homo sapiens)
SYT dimers [plasma membrane] (Homo sapiens)
SYT8 dimer [plasma membrane] (Homo sapiens)
SYT8 [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
STON2,1:SYT dimers [plasma membrane] (Homo sapiens)
SYT dimers [plasma membrane] (Homo sapiens)
SYT8 dimer [plasma membrane] (Homo sapiens)
SYT8 [plasma membrane] (Homo sapiens)
F- and N- BAR domain proteins bind the clathrin-coated pit (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
STON2,1:SYT dimers [plasma membrane] (Homo sapiens)
SYT dimers [plasma membrane] (Homo sapiens)
SYT8 dimer [plasma membrane] (Homo sapiens)
SYT8 [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
STON2,1:SYT dimers [plasma membrane] (Homo sapiens)
SYT dimers [plasma membrane] (Homo sapiens)
SYT8 dimer [plasma membrane] (Homo sapiens)
SYT8 [plasma membrane] (Homo sapiens)
SNX9 recruits components of the actin polymerizing machinery (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
STON2,1:SYT dimers [plasma membrane] (Homo sapiens)
SYT dimers [plasma membrane] (Homo sapiens)
SYT8 dimer [plasma membrane] (Homo sapiens)
SYT8 [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
STON2,1:SYT dimers [plasma membrane] (Homo sapiens)
SYT dimers [plasma membrane] (Homo sapiens)
SYT8 dimer [plasma membrane] (Homo sapiens)
SYT8 [plasma membrane] (Homo sapiens)
SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
STON2,1:SYT dimers [plasma membrane] (Homo sapiens)
SYT dimers [plasma membrane] (Homo sapiens)
SYT8 dimer [plasma membrane] (Homo sapiens)
SYT8 [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
STON2,1:SYT dimers [plasma membrane] (Homo sapiens)
SYT dimers [plasma membrane] (Homo sapiens)
SYT8 dimer [plasma membrane] (Homo sapiens)
SYT8 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8NBV8 SYT8
Gene Names
SYT8
Chain
chain:1-387
Reference Genes
BioGPS Gene:90019 SYT8
COSMIC (genes):SYT8 SYT8
CTD Gene:90019 SYT8
dbSNP Gene:90019 SYT8
ENSEMBL:ENSG00000149043 SYT8
ENSEMBL_homo_sapiens_GENE:ENSG00000149043.17 SYT8
ENSEMBL_homo_sapiens_GENE:ENSG00000288149.1 SYT8
HGNC:19264 SYT8
KEGG Gene (Homo sapiens):90019 SYT8
Monarch:90019 SYT8
NCBI Gene:90019 SYT8
OMIM:607719 SYT8
UCSC:Q8NBV8 SYT8
Reference Transcript
RefSeq:XM_011520457.2 SYT8
RefSeq:XM_017018529.1 SYT8
RefSeq:NM_138567.4 SYT8
Other Identifiers
11755119_a_at
11760742_x_at
232802_PM_at
232802_at
3317034
3317036
3317038
3317039
3317042
3317045
3317047
3317049
3317050
3317051
3317052
3317053
3317054
3317055
55233_at
7937713
90019
A_23_P36187
GO:0001669
GO:0001786
GO:0005509
GO:0005544
GO:0005886
GO:0008289
GO:0014059
GO:0016020
GO:0016192
GO:0017158
GO:0019905
GO:0023052
GO:0030276
GO:0030424
GO:0030672
GO:0031045
GO:0031410
GO:0043226
GO:0048488
GO:0048791
GO:0070382
GO:0071277
HMNXSV003004873
HMNXSV003023251
Hs.161031.0.S1_3p_at
Participates
as a component of
SYT8 dimer [plasma membrane] (Homo sapiens)
Other forms of this molecule
SYT8 [clathrin-coated endocytic vesicle membrane]
Inferred To
Homologues of SYT8 [plasma membrane]
(Caenorhabditis elegans)
Homologues of SYT8 [plasma membrane]
(Drosophila melanogaster)
Syt8 [plasma membrane]
(Mus musculus)
Syt8 [plasma membrane]
(Rattus norvegicus)
SYT8 [plasma membrane]
(Bos taurus)
SYT8 [plasma membrane]
(Caenorhabditis elegans)
SYT8 [plasma membrane]
(Canis familiaris)
SYT8 [plasma membrane]
(Drosophila melanogaster)
SYT8 [plasma membrane]
(Gallus gallus)
SYT8 [plasma membrane]
(Sus scrofa)
syt8 [plasma membrane]
(Xenopus tropicalis)
Sytalpha [plasma membrane]
(Drosophila melanogaster)
snt-5 [plasma membrane]
(Caenorhabditis elegans)
Cross References
RefSeq
XP_011518759.1
,
XP_016874018.1
,
NP_612634.3
OpenTargets
ENSG00000149043
GeneCards
Q8NBV8
HPA
ENSG00000149043-SYT8
Ensembl
ENSG00000149043
,
ENSG00000288149
,
ENST00000381968
,
ENST00000672195
,
ENSP00000371394
,
ENSP00000500064
PRO
Q8NBV8
Pharos - Targets
Q8NBV8
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