Reactome | SYT8 [clathrin-coated endocytic vesicle membrane]

SYT8 [clathrin-coated endocytic vesicle membrane]

Stable Identifier

R-HSA-8869119

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

clathrin-coated endocytic vesicle membrane

Synonyms

Synaptotagmin-8, SYT8_HUMAN

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - Clathrin-mediated endocytosis (Homo sapiens)
    - Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        STON2,1:SYT dimers [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT dimers [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT8 dimer [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT8 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        STON2,1:SYT dimers [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT dimers [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT8 dimer [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT8 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
    - Clathrin recruits auxilins to the clathrin-coated vesicle (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        STON2,1:SYT dimers [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT dimers [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT8 dimer [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT8 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        STON2,1:SYT dimers [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT dimers [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT8 dimer [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT8 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
    - Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        STON2,1:SYT dimers [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT dimers [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT8 dimer [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT8 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        STON2,1:SYT dimers [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT dimers [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT8 dimer [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT8 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
    - Dissociation of clathrin-associated proteins (Homo sapiens)
      - CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        STON2,1:SYT dimers [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT dimers [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT8 dimer [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT8 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        STON2,1:SYT dimers [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT dimers [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT8 dimer [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT8 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        STON2,1:SYT dimers [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT dimers [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT8 dimer [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT8 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
    - HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        STON2,1:SYT dimers [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT dimers [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT8 dimer [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT8 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        STON2,1:SYT dimers [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT dimers [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT8 dimer [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT8 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
    - RAB5 and GAPVD1 bind AP-2 (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        STON2,1:SYT dimers [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT dimers [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT8 dimer [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT8 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q8NBV8 SYT8

Gene Names

SYT8

Chain

chain:1-387

Reference Genes

BioGPS Gene:90019 SYT8

COSMIC (genes):SYT8 SYT8

CTD Gene:90019 SYT8

dbSNP Gene:90019 SYT8

ENSEMBL:ENSG00000149043 SYT8

HGNC:19264 SYT8

KEGG:hsa:90019 SYT8

Monarch:90019 SYT8

NCBI Gene:90019 SYT8

OMIM:607719 SYT8

UCSC:Q8NBV8 SYT8

Reference Transcript

Other Identifiers

11755119_a_at

11760742_x_at

11763109_x_at

16720737

232802_PM_at

232802_at

3317027

3317028

3317029

3317030

3317032

3317033

3317034

3317035

3317036

3317037

3317038

3317039

3317040

3317041

3317042

3317043

3317044

3317045

3317046

3317047

3317048

3317049

3317050

3317051

3317052

3317053

3317054

3317055

3317057

55233_at

7937713

90019

A_23_P36187

A_33_P3364389

GE56788

GO:0000149

GO:0001669

GO:0005544

GO:0005737

GO:0005886

GO:0007340

GO:0016020

GO:0016192

GO:0017158

GO:0022414

GO:0030424

GO:0030672

GO:0031045

GO:0031410

GO:0031982

GO:0043226

GO:0048306

GO:0061891

GO:0070382

GO:0099502

GO:2000300

HMNXSV003004873

HMNXSV003023251

Hs.161031.0.S1_3p_at

ILMN_1679836

PH_hs_0027909

TC11000044.hg

Participates

as a component of

SYT8 dimer [clathrin-coated endocytic vesicle membrane] (Homo sapiens)

Other forms of this molecule

SYT8 [plasma membrane]

Inferred To

snt-1 [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)

snt-5 [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)

SYT8 [clathrin-coated endocytic vesicle membrane] (Bos taurus)

SYT8 [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)

SYT8 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)

SYT8 [clathrin-coated endocytic vesicle membrane] (Gallus gallus)

SYT8 [clathrin-coated endocytic vesicle membrane] (Sus scrofa)

snt-3 [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)

snt-2 [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)

Homologues of SYT8 [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)

Homologues of SYT8 [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)

Syt1 [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)

Syt8 [clathrin-coated endocytic vesicle membrane] (Mus musculus)

Syt8 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)

Sytalpha [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)

Cross References

RefSeq

XP_054188445.1, NP_001381001.1, XP_011518759.1, XP_011518757.2, NP_612634.3, XP_054188446.1, XP_016874018.1, XP_016874017.2

ENSEMBL

ENSG00000288149, ENSP00000499974, ENST00000341958, ENSP00000343691, ENSG00000149043, ENST00000673308

OpenTargets

ENSG00000149043

GeneCards

SYT8

HPA

ENSG00000149043-SYT8

PRO

Q8NBV8

Pharos - Targets

Q8NBV8

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