Reactome | SYT8 [clathrin-coated endocytic vesicle membrane]

SYT8 [clathrin-coated endocytic vesicle membrane]

Stable Identifier

R-HSA-8869119

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

clathrin-coated endocytic vesicle membrane

Synonyms

Synaptotagmin-8, SYT8_HUMAN

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - Clathrin-mediated endocytosis (Homo sapiens)
    - Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        STON2,1:SYT dimers [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT dimers [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT8 dimer [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT8 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        STON2,1:SYT dimers [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT dimers [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT8 dimer [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT8 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
    - Clathrin recruits auxilins to the clathrin-coated vesicle (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        STON2,1:SYT dimers [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT dimers [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT8 dimer [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT8 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        STON2,1:SYT dimers [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT dimers [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT8 dimer [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT8 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
    - Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        STON2,1:SYT dimers [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT dimers [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT8 dimer [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT8 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        STON2,1:SYT dimers [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT dimers [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT8 dimer [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT8 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
    - Dissociation of clathrin-associated proteins (Homo sapiens)
      - CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        STON2,1:SYT dimers [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT dimers [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT8 dimer [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT8 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        STON2,1:SYT dimers [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT dimers [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT8 dimer [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT8 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        STON2,1:SYT dimers [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT dimers [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT8 dimer [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT8 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
    - HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        STON2,1:SYT dimers [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT dimers [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT8 dimer [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT8 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        STON2,1:SYT dimers [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT dimers [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT8 dimer [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT8 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
    - RAB5 and GAPVD1 bind AP-2 (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        STON2,1:SYT dimers [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT dimers [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT8 dimer [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT8 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q8NBV8 SYT8

Gene Names

SYT8

Chain

chain:1-387

Reference Genes

BioGPS Gene:90019 SYT8

COSMIC (genes):SYT8 SYT8

CTD Gene:90019 SYT8

dbSNP Gene:90019 SYT8

ENSEMBL:ENSG00000149043 SYT8

ENSEMBL_homo_sapiens_GENE:ENSG00000149043.17 SYT8

ENSEMBL_homo_sapiens_GENE:ENSG00000288149.1 SYT8

HGNC:19264 SYT8

KEGG Gene (Homo sapiens):90019 SYT8

Monarch:90019 SYT8

NCBI Gene:90019 SYT8

OMIM:607719 SYT8

UCSC:Q8NBV8 SYT8

Reference Transcript

Other Identifiers

11755119_a_at

11760742_x_at

232802_PM_at

232802_at

3317034

3317036

3317038

3317039

3317042

3317045

3317047

3317049

3317050

3317051

3317052

3317053

3317054

3317055

55233_at

7937713

90019

A_23_P36187

GO:0001669

GO:0001786

GO:0005509

GO:0005544

GO:0005886

GO:0008289

GO:0014059

GO:0016020

GO:0016192

GO:0017158

GO:0019905

GO:0023052

GO:0030276

GO:0030424

GO:0030672

GO:0031045

GO:0031410

GO:0043226

GO:0048488

GO:0048791

GO:0070382

GO:0071277

HMNXSV003004873

HMNXSV003023251

Hs.161031.0.S1_3p_at

Participates

as a component of

SYT8 dimer [clathrin-coated endocytic vesicle membrane] (Homo sapiens)

Other forms of this molecule

SYT8 [plasma membrane]

Inferred To

snt-5 [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)

SYT8 [clathrin-coated endocytic vesicle membrane] (Bos taurus)

SYT8 [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)

SYT8 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)

SYT8 [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)

SYT8 [clathrin-coated endocytic vesicle membrane] (Gallus gallus)

SYT8 [clathrin-coated endocytic vesicle membrane] (Sus scrofa)

Homologues of SYT8 [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)

Homologues of SYT8 [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)

Syt8 [clathrin-coated endocytic vesicle membrane] (Mus musculus)

Syt8 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)

Sytalpha [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)

Cross References

RefSeq

XP_016874018.1, NP_612634.3, XP_011518759.1

OpenTargets

ENSG00000149043

GeneCards

Q8NBV8

HPA

ENSG00000149043-SYT8

Ensembl

ENSG00000288149, ENSP00000371394, ENST00000381968, ENSG00000149043, ENST00000672195, ENSP00000500064

PRO

Q8NBV8

Pharos - Targets

Q8NBV8

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