Reactome | SYT8 [plasma membrane]

SYT8 [plasma membrane]

Stable Identifier

R-GGA-5216119

Type

Protein [EntityWithAccessionedSequence]

Species

Gallus gallus

Compartment

plasma membrane

Synonyms

SYT8, A0A8V1A2U0

Locations in the PathwayBrowser

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Vesicle-mediated transport (Gallus gallus)

- Membrane Trafficking (Gallus gallus)
  - Clathrin-mediated endocytosis (Gallus gallus)
    - CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Gallus gallus)
      - CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        STON2,1:SYT dimers [plasma membrane] (Gallus gallus)
        
        SYT dimers [plasma membrane] (Gallus gallus)
        
        SYT8 dimer [plasma membrane] (Gallus gallus)
        
        SYT8 [plasma membrane] (Gallus gallus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        STON2,1:SYT dimers [plasma membrane] (Gallus gallus)
        
        SYT dimers [plasma membrane] (Gallus gallus)
        
        SYT8 dimer [plasma membrane] (Gallus gallus)
        
        SYT8 [plasma membrane] (Gallus gallus)
    - Cargo recognition for clathrin-mediated endocytosis (Gallus gallus)
      - STON2 binds SYT proteins (Gallus gallus)
        
        STON2,1:SYT dimers [plasma membrane] (Gallus gallus)
        
        SYT dimers [plasma membrane] (Gallus gallus)
        
        SYT8 dimer [plasma membrane] (Gallus gallus)
        
        SYT8 [plasma membrane] (Gallus gallus)
        
        SYT dimers [plasma membrane] (Gallus gallus)
        
        SYT8 dimer [plasma membrane] (Gallus gallus)
        
        SYT8 [plasma membrane] (Gallus gallus)
    - Clathrin recruits PIK3C2A (Gallus gallus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        STON2,1:SYT dimers [plasma membrane] (Gallus gallus)
        
        SYT dimers [plasma membrane] (Gallus gallus)
        
        SYT8 dimer [plasma membrane] (Gallus gallus)
        
        SYT8 [plasma membrane] (Gallus gallus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        STON2,1:SYT dimers [plasma membrane] (Gallus gallus)
        
        SYT dimers [plasma membrane] (Gallus gallus)
        
        SYT8 dimer [plasma membrane] (Gallus gallus)
        
        SYT8 [plasma membrane] (Gallus gallus)
    - Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Gallus gallus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        STON2,1:SYT dimers [plasma membrane] (Gallus gallus)
        
        SYT dimers [plasma membrane] (Gallus gallus)
        
        SYT8 dimer [plasma membrane] (Gallus gallus)
        
        SYT8 [plasma membrane] (Gallus gallus)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Gallus gallus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Gallus gallus)
        
        CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        STON2,1:SYT dimers [plasma membrane] (Gallus gallus)
        
        SYT dimers [plasma membrane] (Gallus gallus)
        
        SYT8 dimer [plasma membrane] (Gallus gallus)
        
        SYT8 [plasma membrane] (Gallus gallus)
    - Endophilins recruit synaptojanins to the clathrin-coated pit (Gallus gallus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        STON2,1:SYT dimers [plasma membrane] (Gallus gallus)
        
        SYT dimers [plasma membrane] (Gallus gallus)
        
        SYT8 dimer [plasma membrane] (Gallus gallus)
        
        SYT8 [plasma membrane] (Gallus gallus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        STON2,1:SYT dimers [plasma membrane] (Gallus gallus)
        
        SYT dimers [plasma membrane] (Gallus gallus)
        
        SYT8 dimer [plasma membrane] (Gallus gallus)
        
        SYT8 [plasma membrane] (Gallus gallus)
    - SNX9 recruits components of the actin polymerizing machinery (Gallus gallus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        STON2,1:SYT dimers [plasma membrane] (Gallus gallus)
        
        SYT dimers [plasma membrane] (Gallus gallus)
        
        SYT8 dimer [plasma membrane] (Gallus gallus)
        
        SYT8 [plasma membrane] (Gallus gallus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        STON2,1:SYT dimers [plasma membrane] (Gallus gallus)
        
        SYT dimers [plasma membrane] (Gallus gallus)
        
        SYT8 dimer [plasma membrane] (Gallus gallus)
        
        SYT8 [plasma membrane] (Gallus gallus)
    - SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Gallus gallus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Gallus gallus)
        
        CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        STON2,1:SYT dimers [plasma membrane] (Gallus gallus)
        
        SYT dimers [plasma membrane] (Gallus gallus)
        
        SYT8 dimer [plasma membrane] (Gallus gallus)
        
        SYT8 [plasma membrane] (Gallus gallus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        STON2,1:SYT dimers [plasma membrane] (Gallus gallus)
        
        SYT dimers [plasma membrane] (Gallus gallus)
        
        SYT8 dimer [plasma membrane] (Gallus gallus)
        
        SYT8 [plasma membrane] (Gallus gallus)

External Reference Information

External Reference

UniProt:A0A8V1A2U0

Gene Names

SYT8

Reference Genes

ENSEMBL:ENSGALG00010024615.1

UCSC:A0A8V1A2U0 SYT8

Other Identifiers

423095

GO:0000149

GO:0005544

GO:0005737

GO:0005886

GO:0007340

GO:0016020

GO:0016192

GO:0017158

GO:0022414

GO:0030424

GO:0030672

GO:0031045

GO:0031410

GO:0031982

GO:0043226

GO:0045202

GO:0046872

GO:0048306

GO:0061891

GO:0070382

GO:0099502

GO:2000300

Gga.12005.1.S1_at

Participates

as a component of

SYT8 dimer [plasma membrane] (Gallus gallus)

Other forms of this molecule

SYT8 [clathrin-coated endocytic vesicle membrane]

Inferred From

SYT8 [plasma membrane] (Homo sapiens)

Cross References

ENSEMBL

ENSGALG00010024615, ENSGALT00010060060, ENSGALP00010036820

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