Reactome | ATP5MC3 [mitochondrial inner membrane]

ATP5MC3 [mitochondrial inner membrane]

Stable Identifier

R-HSA-5216110

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial inner membrane

Synonyms

ATP5G3, ATP synthase subunit c, AT5G3_HUMAN

Locations in the PathwayBrowser

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Metabolism (Homo sapiens)

- Aerobic respiration and respiratory electron transport (Homo sapiens)
  - Formation of ATP by chemiosmotic coupling (Homo sapiens)
    - ADP and Pi bind to ATPase (Homo sapiens)
      - ATPase:ADP:Pi [mitochondrial inner membrane] (Homo sapiens)
        
        F1Fo ATP synthase [mitochondrial inner membrane] (Homo sapiens)
        
        ATPase CF(0) [mitochondrial inner membrane] (Homo sapiens)
        
        ATP synthase subunit c [mitochondrial inner membrane] (Homo sapiens)
        
        ATP5MC3 [mitochondrial inner membrane] (Homo sapiens)
      - F1Fo ATP synthase [mitochondrial inner membrane] (Homo sapiens)
        
        ATPase CF(0) [mitochondrial inner membrane] (Homo sapiens)
        
        ATP synthase subunit c [mitochondrial inner membrane] (Homo sapiens)
        
        ATP5MC3 [mitochondrial inner membrane] (Homo sapiens)
    - ATPase synthesizes ATP (Homo sapiens)
      - ATPase:ADP:Pi [mitochondrial inner membrane] (Homo sapiens)
        
        F1Fo ATP synthase [mitochondrial inner membrane] (Homo sapiens)
        
        ATPase CF(0) [mitochondrial inner membrane] (Homo sapiens)
        
        ATP synthase subunit c [mitochondrial inner membrane] (Homo sapiens)
        
        ATP5MC3 [mitochondrial inner membrane] (Homo sapiens)
      - ATPase:ATP [mitochondrial inner membrane] (Homo sapiens)
        
        F1Fo ATP synthase [mitochondrial inner membrane] (Homo sapiens)
        
        ATPase CF(0) [mitochondrial inner membrane] (Homo sapiens)
        
        ATP synthase subunit c [mitochondrial inner membrane] (Homo sapiens)
        
        ATP5MC3 [mitochondrial inner membrane] (Homo sapiens)
      - F1Fo ATP synthase [mitochondrial inner membrane] (Homo sapiens)
        
        ATPase CF(0) [mitochondrial inner membrane] (Homo sapiens)
        
        ATP synthase subunit c [mitochondrial inner membrane] (Homo sapiens)
        
        ATP5MC3 [mitochondrial inner membrane] (Homo sapiens)
    - Enzyme-bound ATP is released (Homo sapiens)
      - ATPase:ATP [mitochondrial inner membrane] (Homo sapiens)
        
        F1Fo ATP synthase [mitochondrial inner membrane] (Homo sapiens)
        
        ATPase CF(0) [mitochondrial inner membrane] (Homo sapiens)
        
        ATP synthase subunit c [mitochondrial inner membrane] (Homo sapiens)
        
        ATP5MC3 [mitochondrial inner membrane] (Homo sapiens)
      - F1Fo ATP synthase [mitochondrial inner membrane] (Homo sapiens)
        
        ATPase CF(0) [mitochondrial inner membrane] (Homo sapiens)
        
        ATP synthase subunit c [mitochondrial inner membrane] (Homo sapiens)
        
        ATP5MC3 [mitochondrial inner membrane] (Homo sapiens)

Organelle biogenesis and maintenance (Homo sapiens)

- Mitochondrial biogenesis (Homo sapiens)
  - Cristae formation (Homo sapiens)
    - F1Fo ATP synthase dimerizes (Homo sapiens)
      - F1Fo ATP synthase [mitochondrial inner membrane] (Homo sapiens)
        
        ATPase CF(0) [mitochondrial inner membrane] (Homo sapiens)
        
        ATP synthase subunit c [mitochondrial inner membrane] (Homo sapiens)
        
        ATP5MC3 [mitochondrial inner membrane] (Homo sapiens)
      - F1Fo ATP synthase dimer [mitochondrial inner membrane] (Homo sapiens)
        
        F1Fo ATP synthase [mitochondrial inner membrane] (Homo sapiens)
        
        ATPase CF(0) [mitochondrial inner membrane] (Homo sapiens)
        
        ATP synthase subunit c [mitochondrial inner membrane] (Homo sapiens)
        
        ATP5MC3 [mitochondrial inner membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P48201 ATP5MC3

Gene Names

ATP5MC3, ATP5G3

Chain

transit peptide:1-67, chain:68-142

Reference Genes

BioGPS Gene:518 ATP5MC3

COSMIC (genes):ATP5MC3 ATP5MC3

CTD Gene:518 ATP5MC3

dbSNP Gene:518 ATP5MC3

ENSEMBL:ENSG00000154518 ATP5G3

HGNC:843 ATP5MC3

KEGG:hsa:518 ATP5MC3

Monarch:518 ATP5MC3

NCBI Gene:518 ATP5MC3

OMIM:602736 ATP5MC3

UCSC:P48201 ATP5MC3

Reference Transcript

Other Identifiers

11739201_a_at

11739202_a_at

11757281_a_at

11757282_x_at

16905355

207507_PM_s_at

207507_s_at

207508_PM_at

207508_at

228168_PM_at

228168_at

2588126

2588128

2588129

2588130

2588131

2588132

2588133

2588134

2588135

2588136

2588137

2588138

2588139

2588140

2588141

2588142

2588143

2588144

34811_at

518

74703_f_at

8056930

A_23_P56680

A_24_P174346

GE78954

GO:0005215

GO:0005515

GO:0005739

GO:0005743

GO:0008289

GO:0015078

GO:0015986

GO:0016020

GO:0031966

GO:0033177

GO:0043226

GO:0045263

GO:0055085

GO:0055086

GO:1901135

GO:1902600

HMNXSV003035663

Hs.429.2.A1_3p_at

ILMN_1770466

PH_hs_0000052

TC02002547.hg

TC02004706.hg

U09813_at

g4502300_3p_s_at

Participates

as a member of

ATP synthase subunit c [mitochondrial inner membrane] (Homo sapiens)

Inferred To

ATP5MC3 [mitochondrial inner membrane] (Caenorhabditis elegans)

ATP5MC3 [mitochondrial inner membrane] (Canis familiaris)

ATP5MC3 [mitochondrial inner membrane] (Gallus gallus)

ATP5MC3 [mitochondrial inner membrane] (Sus scrofa)

ATP5MC2 [mitochondrial inner membrane] (Bos taurus)

atp5mc3a [mitochondrial inner membrane] (Danio rerio)

ATPsynC [mitochondrial inner membrane] (Drosophila melanogaster)

Atp5mc2 [mitochondrial inner membrane] (Rattus norvegicus)

Atp5mc1 [mitochondrial inner membrane] (Mus musculus)

Cross References

ENSEMBL

ENSG00000154518, ENST00000284727, ENSP00000284727, ENST00000409194, ENST00000392541, ENSP00000387317, ENSP00000376324

OpenTargets

ENSG00000154518

GeneCards

ATP5MC3

HPA

ENSG00000154518-ATP5MC3

PRO

P48201

Pharos - Targets

P48201

GlyGen

P48201

HMDB Protein

HMDBP03102

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P06576 ATP5F1B	6	ATP5F1B [mitochondrial matrix] (R-HSA-164576) ATP5B(1-47) [mitochondrial matrix] (R-HSA-8986172) ATP5B(1-529) [cytosol] (R-HSA-1267973) ATP5B(1-529) [mitochondrial intermembrane space] (R-HSA-1267985) ATP5B(1-529) [mitochondrial inner membrane] (R-HSA-1299440) ATP5B [mitochondrial inner membrane] (R-HSA-1299441)	0.527	2