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VLDLR [plasma membrane]
Stable Identifier
R-HSA-5216079
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Very low-density lipoprotein receptor, VLDLR_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
Reelin signalling pathway (Homo sapiens)
FYN phosphorylates DAB1 in RELN:VLDLR:DAB1:SH3KBP1 (Homo sapiens)
RELN:VLDLR:DAB1:SH3KBP1 [plasma membrane] (Homo sapiens)
RELN:VLDLR:DAB1 [plasma membrane] (Homo sapiens)
RELN:VLDLR [plasma membrane] (Homo sapiens)
VLDLR [plasma membrane] (Homo sapiens)
RELN:VLDLR:p-Y198,220,232-DAB1:SH3KBP1 [plasma membrane] (Homo sapiens)
VLDLR [plasma membrane] (Homo sapiens)
RELN:VLDLR binds DAB1 (Homo sapiens)
RELN:VLDLR [plasma membrane] (Homo sapiens)
VLDLR [plasma membrane] (Homo sapiens)
RELN:VLDLR:DAB1 [plasma membrane] (Homo sapiens)
RELN:VLDLR [plasma membrane] (Homo sapiens)
VLDLR [plasma membrane] (Homo sapiens)
RELN:VLDLR:DAB1 binds SH3KBP1 (Homo sapiens)
RELN:VLDLR:DAB1 [plasma membrane] (Homo sapiens)
RELN:VLDLR [plasma membrane] (Homo sapiens)
VLDLR [plasma membrane] (Homo sapiens)
RELN:VLDLR:DAB1:SH3KBP1 [plasma membrane] (Homo sapiens)
RELN:VLDLR:DAB1 [plasma membrane] (Homo sapiens)
RELN:VLDLR [plasma membrane] (Homo sapiens)
VLDLR [plasma membrane] (Homo sapiens)
VLDLR binds RELN (Homo sapiens)
RELN:VLDLR [plasma membrane] (Homo sapiens)
VLDLR [plasma membrane] (Homo sapiens)
VLDLR [plasma membrane] (Homo sapiens)
Transport of small molecules (Homo sapiens)
Plasma lipoprotein assembly, remodeling, and clearance (Homo sapiens)
Plasma lipoprotein clearance (Homo sapiens)
VLDL clearance (Homo sapiens)
VLDLR binds VLDL (Homo sapiens)
VLDL:VLDLR [plasma membrane] (Homo sapiens)
VLDLR [plasma membrane] (Homo sapiens)
VLDLR [plasma membrane] (Homo sapiens)
VLDLR internalisation and degradation (Homo sapiens)
MYLIP dimer ubiquitinates VLDLR on Lys-839 (Homo sapiens)
VLDLR [plasma membrane] (Homo sapiens)
VLDLR binds PCSK9 (Homo sapiens)
VLDL:PCSK9 [plasma membrane] (Homo sapiens)
VLDLR [plasma membrane] (Homo sapiens)
VLDLR [plasma membrane] (Homo sapiens)
VLDLR:PCSK9 binds Clathrin-coated vesicles (Homo sapiens)
VLDL:PCSK9 [plasma membrane] (Homo sapiens)
VLDLR [plasma membrane] (Homo sapiens)
VLDL:PCSK9:Clathrin:AP2 [plasma membrane] (Homo sapiens)
VLDL:PCSK9 [plasma membrane] (Homo sapiens)
VLDLR [plasma membrane] (Homo sapiens)
VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane (Homo sapiens)
VLDL:PCSK9:Clathrin:AP2 [plasma membrane] (Homo sapiens)
VLDL:PCSK9 [plasma membrane] (Homo sapiens)
VLDLR [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P98155 VLDLR
Gene Names
VLDLR
Chain
signal peptide:1-27, chain:28-873
Reference Genes
BioGPS Gene:7436 VLDLR
COSMIC (genes):VLDLR VLDLR
CTD Gene:7436 VLDLR
dbSNP Gene:7436 VLDLR
ENSEMBL:ENSG00000147852 VLDLR
HGNC:12698 VLDLR
KEGG Gene (Homo sapiens):7436 VLDLR
Monarch:7436 VLDLR
NCBI Gene:7436 VLDLR
OMIM:192977 VLDLR
UCSC:P98155 VLDLR
Reference Transcript
RefSeq:NM_003383.4 VLDLR
RefSeq:NM_001018056.2 VLDLR
Other Identifiers
0006450736
11721181_a_at
17083197
209822_s_at
3160176
3160177
3160178
3160182
3160183
3160185
3160186
3160187
3160188
3160190
3160191
3160192
3160194
3160196
3160198
3160201
3160203
3160204
3160205
3160206
3160208
3160209
3160211
3160213
3160214
3160215
3160216
3160217
3160218
3160219
3160220
3160221
3160222
3160223
36873_at
7436
8154100
A_23_P43476
A_32_P128586
A_33_P3284925
D16532_at
GE57664
GE60482
GE733538
GO:0000902
GO:0003674
GO:0005041
GO:0005509
GO:0005515
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005737
GO:0005764
GO:0005765
GO:0005773
GO:0005886
GO:0005905
GO:0006464
GO:0006629
GO:0006810
GO:0006869
GO:0006897
GO:0006898
GO:0007165
GO:0007399
GO:0007411
GO:0007613
GO:0008150
GO:0008202
GO:0008203
GO:0009056
GO:0015031
GO:0016020
GO:0016021
GO:0016192
GO:0021517
GO:0030154
GO:0030229
GO:0032802
GO:0032991
GO:0034185
GO:0034189
GO:0034361
GO:0034436
GO:0034447
GO:0038024
GO:0038025
GO:0038026
GO:0040011
GO:0043167
GO:0043226
GO:0043235
GO:0044281
GO:0045860
GO:0048306
GO:0048813
GO:0048856
GO:0050877
GO:1900006
HMNXSV003023004
ILMN_1675092
ILMN_2361862
PH_hs_0024141
TC09000015.hg
g437386_3p_a_at
Participates
as an input of
MYLIP dimer ubiquitinates VLDLR on Lys-839 (Homo sapiens)
VLDLR binds PCSK9 (Homo sapiens)
VLDLR binds VLDL (Homo sapiens)
VLDLR binds RELN (Homo sapiens)
as a component of
VLDL:PCSK9 [plasma membrane] (Homo sapiens)
VLDL:VLDLR [plasma membrane] (Homo sapiens)
RELN:VLDLR:p-Y198,220,232-DAB1:SH3KBP1 [plasma membrane] (Homo sapiens)
RELN:VLDLR [plasma membrane] (Homo sapiens)
Other forms of this molecule
VLDLR [lysosomal membrane]
Ub-K839-VLDLR [plasma membrane]
Inferred To
LpR2 [plasma membrane]
(Drosophila melanogaster)
Ghost homologue of VLDLR [plasma membrane]
(Dictyostelium discoideum)
Ghost homologue of VLDLR [plasma membrane]
(Gallus gallus)
Ghost homologue of VLDLR [plasma membrane]
(Saccharomyces cerevisiae)
Ghost homologue of VLDLR [plasma membrane]
(Schizosaccharomyces pombe)
Vldlr [plasma membrane]
(Mus musculus)
Vldlr [plasma membrane]
(Rattus norvegicus)
VLDLR [plasma membrane]
(Bos taurus)
VLDLR [plasma membrane]
(Caenorhabditis elegans)
VLDLR [plasma membrane]
(Canis familiaris)
VLDLR [plasma membrane]
(Sus scrofa)
vldlr [plasma membrane]
(Danio rerio)
vldlr [plasma membrane]
(Xenopus tropicalis)
Homologues of VLDLR [plasma membrane]
(Drosophila melanogaster)
LpR1 [plasma membrane]
(Drosophila melanogaster)
Cross References
RefSeq
NP_003374.3
,
NP_001018066.1
OpenTargets
ENSG00000147852
HPA
ENSG00000147852-VLDLR
GeneCards
P98155
Ensembl
ENSP00000371531
,
ENST00000382100
,
ENST00000382099
,
ENSP00000371532
,
ENSG00000147852
PRO
P98155
Pharos - Targets
P98155
Orphanet
15709
GlyGen
P98155
PDB
3DPR
,
6BYV
,
1V9U
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q60841
1
Reln [extracellular region]
(R-MMU-8854469)
0.775
7
UniProt:P30533 AMRP
0.704
5
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