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CLIP3 [cytosol]
Stable Identifier
R-HSA-5212669
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
CLIPR59, CAP-Gly domain-containing linker protein 3
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Death Receptor Signaling (Homo sapiens)
TNF signaling (Homo sapiens)
Regulation of TNFR1 signaling (Homo sapiens)
CLIP3 and CYLD bind TNF signaling complex (Homo sapiens)
CLIP3 [cytosol] (Homo sapiens)
CYLD:CLIP3:TNF:TNFR1:TRADD:K63pUb-RIP1:TRAF2:BIRC2/3 [plasma membrane] (Homo sapiens)
CLIP3 [cytosol] (Homo sapiens)
K63polyUb-RIPK1 is deubiquitinated (Homo sapiens)
CLIP3 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q96DZ5 CLIP3
Gene Names
CLIP3, CLIPR59
Chain
chain:1-547
Reference Genes
BioGPS Gene:25999 CLIP3
COSMIC (genes):CLIP3 CLIP3
CTD Gene:25999 CLIP3
dbSNP Gene:25999 CLIP3
ENSEMBL:ENSG00000105270 CLIP3
HGNC:24314 CLIP3
KEGG:hsa:25999 CLIP3
Monarch:25999 CLIP3
NCBI Gene:25999 CLIP3
OMIM:607382 CLIP3
UCSC:Q96DZ5 CLIP3
Reference Transcript
RefSeq:NM_015526.2 CLIP3
RefSeq:NM_001199570.1 CLIP3
Other Identifiers
11718473_a_at
11755130_s_at
16871586
212358_PM_at
212358_at
235243_PM_at
235243_at
25999
36095_at
3860224
3860225
3860226
3860227
3860228
3860230
3860231
3860232
3860233
3860234
3860235
3860236
3860237
3860238
3860239
3860241
3860242
3860243
3860244
3860245
3860246
3860247
3860248
3860249
3860250
3860251
3860252
3860253
3860254
3860255
3860256
3860257
3860258
8036252
87304_at
A_23_P50786
A_24_P279718
GE56477
GO:0001934
GO:0005515
GO:0005634
GO:0005737
GO:0005794
GO:0005795
GO:0005802
GO:0005829
GO:0005886
GO:0005938
GO:0006886
GO:0007010
GO:0007018
GO:0008017
GO:0008092
GO:0008289
GO:0010828
GO:0018230
GO:0030154
GO:0031115
GO:0031122
GO:0031901
GO:0032588
GO:0035371
GO:0035594
GO:0043065
GO:0043226
GO:0044091
GO:0045121
GO:0045444
GO:0045807
GO:0051010
GO:0055038
GO:0098840
GO:1903078
Hs.322427.0.S1_3p_at
Hs.7357.0.S1_3p_at
ILMN_1789733
PH_hs_0000762
TC19001460.hg
Participates
as a component of
CYLD:CLIP3:TNF:TNFR1:TRADD:K63pUb-RIP1:TRAF2:BIRC2/3 [plasma membrane] (Homo sapiens)
as an input of
CLIP3 and CYLD bind TNF signaling complex (Homo sapiens)
This entity regulates
Positively
K63polyUb-RIPK1 is deubiquitinated
(Homo sapiens)
Inferred To
clip3 [cytosol]
(Xenopus tropicalis)
dynA [cytosol]
(Dictyostelium discoideum)
Clip3 [cytosol]
(Mus musculus)
NIP100 [cytosol]
(Saccharomyces cerevisiae)
CLIP3 [cytosol]
(Bos taurus)
CLIP3 [cytosol]
(Canis familiaris)
CLIP3 [cytosol]
(Sus scrofa)
clip-1 [cytosol]
(Caenorhabditis elegans)
Cross References
RefSeq
NP_001186499.1
,
NP_056341.1
ENSEMBL
ENST00000593074
,
ENST00000360535
,
ENSP00000353732
,
ENSP00000466832
OpenTargets
ENSG00000105270
HPA
ENSG00000105270-CLIP3
PRO
Q96DZ5
Pharos - Targets
Q96DZ5
PDB
2CP0
Interactors (8)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O76024 WFS1
3
WFS1 [endoplasmic reticulum lumen]
(R-HSA-8956747)
p-WFS1 [endoplasmic reticulum lumen]
(R-HSA-8956998)
WFS1 [endoplasmic reticulum membrane]
(R-HSA-535474)
0.556
3
UniProt:Q9Y592-2 CEP83
0.556
3
UniProt:P28799 GRN
2
GRN [azurophil granule lumen]
(R-HSA-6799168)
GRN [extracellular region]
(R-HSA-6806217)
0.556
3
UniProt:Q08117-2 TLE5
0.556
3
UniProt:O60333-2 KIF1B
0.556
3
UniProt:Q9Y3C5 RNF11
0.556
3
UniProt:P04792 HSBP1
3
HSPB1 [cytosol]
(R-HSA-450563)
p-S15,S78,S82-HSP27 [cytosol]
(R-HSA-5218697)
p-S78,S82 HSPB1 [cytosol]
(R-HSA-5687009)
0.556
3
UniProt:Q08379 GOLGA2
3
p-S37-GOLGA2 [Golgi membrane]
(R-HSA-2172179)
GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-2167933)
GOLGA2 [Golgi membrane]
(R-HSA-6808764)
0.556
3
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