Reactome | CARM1, PRMT6 methylate arginine-3 of histone H3 (H3R2)

CARM1, PRMT6 methylate arginine-3 of histone H3 (H3R2)

Stable Identifier

R-HSA-5205824

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

CARM1, PRMT6 methylate arginine-3 of histone H3

ReviewStatus

5/5

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CARM1, PRMT6 methylate arginine-3 of histone H3 (H3R2)

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PRMT6 (Guccione et al. 2007, Hyllus et al. 2007) and CARM1 (PRMT4) (Schurter et al. 2001, Torres-Padilla et al. 2007) can methylate arginine-3 of histone H3 (H3R2). PRMT6 predominantly asymmetrically dimethylates H3R2 and is the major cellular H3R2 methyltransferase. It has higher activity toward the monomethylated form of the peptide than the unmethylated form (Hyllus et al. 2007).

Literature References

PubMed ID	Title	Journal	Year
17215844	Histone arginine methylation regulates pluripotency in the early mouse embryo Torres-Padilla, ME, Parfitt, DE, Kouzarides, T, Zernicka-Goetz, M	Nature	2007
17898714	Methylation of histone H3R2 by PRMT6 and H3K4 by an MLL complex are mutually exclusive Guccione, E, Bassi, C, Casadio, F, Martinato, F, Cesaroni, M, Schuchlautz, H, Lüscher, B, Amati, B	Nature	2007
11341840	Methylation of histone H3 by coactivator-associated arginine methyltransferase 1 Schurter, BT, Koh, SS, Chen, D, Bunick, GJ, Harp, JM, Hanson, BL, Henschen-Edman, A, Mackay, DR, Stallcup, MR, Aswad, DW	Biochemistry	2001
18079182	PRMT6-mediated methylation of R2 in histone H3 antagonizes H3 K4 trimethylation Hyllus, D, Stein, C, Schnabel, K, Schiltz, E, Imhof, A, Dou, Y, Hsieh, J, Bauer, UM	Genes Dev.	2007