PRMT6 methylates arginine-4 of histone H2A (H2AR3)

Stable Identifier
R-HSA-5205820
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
PRMT6 methylates arginine-4 of histone H2A
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PRMT6 methylates arginine-4 of histone H2A (H2AR3)
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PRMT6 is the predominant in vivo methylator of H3R2 (Hyllus et al. 2007, Guccione et al. 2007) and in addition able to methylate arginine-4 of histone H4 (R3H4) and arginine-4 of histone H2A (R3H2A) (Hyllus et al. 2007).

Literature References
PubMed ID Title Journal Year
18079182 PRMT6-mediated methylation of R2 in histone H3 antagonizes H3 K4 trimethylation

Hyllus, D, Stein, C, Schnabel, K, Schiltz, E, Imhof, A, Dou, Y, Hsieh, J, Bauer, UM

Genes Dev. 2007
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
protein-arginine N-methyltransferase activity of PRMT6 [nucleoplasm]
Physical Entity
PRMT6 [nucleoplasm]
Activity
protein-arginine N-methyltransferase activity (0016274)
Orthologous Events
PRMT6 methylates arginine-4 of histone H2A (H2AR3) (Bos taurus)
PRMT6 methylates arginine-4 of histone H2A (H2AR3) (Canis familiaris)
PRMT6 methylates arginine-4 of histone H2A (H2AR3) (Danio rerio)
PRMT6 methylates arginine-4 of histone H2A (H2AR3) (Mus musculus)
PRMT6 methylates arginine-4 of histone H2A (H2AR3) (Sus scrofa)
PRMT6 methylates arginine-4 of histone H2A (H2AR3) (Xenopus tropicalis)
Authored
Jupe, S  (2013-03-12)
Reviewed
Guccione, E  (2014-05-09)
Fischle, W  (2014-07-23)
Created
Jupe, S  (2013-12-06)