PRMT6 methylates arginine-4 of histone H2A (H2AR3)

Stable Identifier
R-HSA-5205820
Type
Reaction
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
PRMT6 methylates arginine-4 of histone H2A
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PRMT6 methylates arginine-4 of histone H2A (H2AR3)
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PRMT6 is the predominant in vivo methylator of H3R2 (Hyllus et al. 2007, Guccione et al. 2007) and in addition able to methylate arginine-4 of histone H4 (R3H4) and arginine-4 of histone H2A (R3H2A) (Hyllus et al. 2007).

Literature References
PubMed ID Title Journal Year
18079182 PRMT6-mediated methylation of R2 in histone H3 antagonizes H3 K4 trimethylation

Schnabel, K, Schiltz, E, Bauer, UM, Stein, C, Hsieh, J, Imhof, A, Dou, Y, Hyllus, D

Genes Dev. 2007
Participants
Input
Output
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as an event of
Catalyst Activity

protein-arginine N-methyltransferase activity of PRMT6 [nucleoplasm]

Physical Entity
PRMT6 [nucleoplasm] (Homo sapiens)
Activity
protein-arginine N-methyltransferase activity (GO:0016274)
Orthologous Events
PRMT6 methylates arginine-4 of histone H2A (H2AR3) (Bos taurus)
PRMT6 methylates arginine-4 of histone H2A (H2AR3) (Canis familiaris)
PRMT6 methylates arginine-4 of histone H2A (H2AR3) (Danio rerio)
PRMT6 methylates arginine-4 of histone H2A (H2AR3) (Drosophila melanogaster)
PRMT6 methylates arginine-4 of histone H2A (H2AR3) (Mus musculus)
PRMT6 methylates arginine-4 of histone H2A (H2AR3) (Sus scrofa)
PRMT6 methylates arginine-4 of histone H2A (H2AR3) (Xenopus tropicalis)
Authored
Jupe, S  (2013-03-12)
Reviewed
Fischle, W  (2014-07-23)
Guccione, E  (2014-05-09)
Created
Jupe, S  (2013-12-06)
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