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PPP3R1 [cytosol]
Stable Identifier
R-HSA-51291
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Calcineurin B, alpha regulatory, Calcineurin B subunit isoform 1, Protein phosphatase 2B regulatory subunit 1, Protein phosphatase 3 regulatory subunit B alpha isoform 1
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Signaling by the B Cell Receptor (BCR) (Homo sapiens)
Downstream signaling events of B Cell Receptor (BCR) (Homo sapiens)
Calcineurin activates NFAT (Homo sapiens)
Calcineurin binds NFATC1,2,3 (Homo sapiens)
Calcineurin (CaN) [cytosol] (Homo sapiens)
PPP3R1 [cytosol] (Homo sapiens)
Calcineurin:Phosphorylated NFATC1,2,3 [cytosol] (Homo sapiens)
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Homo sapiens)
Calcineurin alpha regulatory subunit:Calcium [cytosol] (Homo sapiens)
PPP3R1 [cytosol] (Homo sapiens)
Calcineurin dephosphorylates NFATC1,2,3 (Homo sapiens)
Calcineurin:Phosphorylated NFATC1,2,3 [cytosol] (Homo sapiens)
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Homo sapiens)
Calcineurin alpha regulatory subunit:Calcium [cytosol] (Homo sapiens)
PPP3R1 [cytosol] (Homo sapiens)
Innate Immune System (Homo sapiens)
C-type lectin receptors (CLRs) (Homo sapiens)
CLEC7A (Dectin-1) signaling (Homo sapiens)
CLEC7A (Dectin-1) induces NFAT activation (Homo sapiens)
Activation of Calcineurin (Homo sapiens)
Calcineurin (CaN) [cytosol] (Homo sapiens)
PPP3R1 [cytosol] (Homo sapiens)
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Homo sapiens)
Calcineurin alpha regulatory subunit:Calcium [cytosol] (Homo sapiens)
PPP3R1 [cytosol] (Homo sapiens)
Calcineurin binds and dephosphorylates NFAT (Homo sapiens)
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Homo sapiens)
Calcineurin alpha regulatory subunit:Calcium [cytosol] (Homo sapiens)
PPP3R1 [cytosol] (Homo sapiens)
NFAT:CaN:CaM [cytosol] (Homo sapiens)
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Homo sapiens)
Calcineurin alpha regulatory subunit:Calcium [cytosol] (Homo sapiens)
PPP3R1 [cytosol] (Homo sapiens)
Translocation of CaN:CaM:NFAT to nucleus (Homo sapiens)
NFAT:CaN:CaM [cytosol] (Homo sapiens)
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Homo sapiens)
Calcineurin alpha regulatory subunit:Calcium [cytosol] (Homo sapiens)
PPP3R1 [cytosol] (Homo sapiens)
Fc epsilon receptor (FCERI) signaling (Homo sapiens)
FCERI mediated Ca+2 mobilization (Homo sapiens)
Activation of Calcineurin (Homo sapiens)
Calcineurin (CaN) [cytosol] (Homo sapiens)
PPP3R1 [cytosol] (Homo sapiens)
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Homo sapiens)
Calcineurin alpha regulatory subunit:Calcium [cytosol] (Homo sapiens)
PPP3R1 [cytosol] (Homo sapiens)
Calcineurin binds and dephosphorylates NFAT (Homo sapiens)
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Homo sapiens)
Calcineurin alpha regulatory subunit:Calcium [cytosol] (Homo sapiens)
PPP3R1 [cytosol] (Homo sapiens)
NFAT:CaN:CaM [cytosol] (Homo sapiens)
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Homo sapiens)
Calcineurin alpha regulatory subunit:Calcium [cytosol] (Homo sapiens)
PPP3R1 [cytosol] (Homo sapiens)
Translocation of CaN:CaM:NFAT to nucleus (Homo sapiens)
NFAT:CaN:CaM [cytosol] (Homo sapiens)
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Homo sapiens)
Calcineurin alpha regulatory subunit:Calcium [cytosol] (Homo sapiens)
PPP3R1 [cytosol] (Homo sapiens)
Programmed Cell Death (Homo sapiens)
Apoptosis (Homo sapiens)
Intrinsic Pathway for Apoptosis (Homo sapiens)
Activation of BH3-only proteins (Homo sapiens)
Activation of BAD and translocation to mitochondria (Homo sapiens)
Activation of BAD by calcineurin (Homo sapiens)
Calcineurin B complex [cytosol] (Homo sapiens)
PPP3R1 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Opioid Signalling (Homo sapiens)
DARPP-32 events (Homo sapiens)
PPP3 complex dephosphorylates DARPP-32 on Thr34 (Homo sapiens)
PPP3 complex [cytosol] (Homo sapiens)
PPP3R1 [cytosol] (Homo sapiens)
Signaling by WNT (Homo sapiens)
Beta-catenin independent WNT signaling (Homo sapiens)
Ca2+ pathway (Homo sapiens)
Activation of Calcineurin (Homo sapiens)
Calcineurin (CaN) [cytosol] (Homo sapiens)
PPP3R1 [cytosol] (Homo sapiens)
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Homo sapiens)
Calcineurin alpha regulatory subunit:Calcium [cytosol] (Homo sapiens)
PPP3R1 [cytosol] (Homo sapiens)
Calcineurin binds and dephosphorylates NFAT1 in response to WNT/Ca2+ signaling (Homo sapiens)
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Homo sapiens)
Calcineurin alpha regulatory subunit:Calcium [cytosol] (Homo sapiens)
PPP3R1 [cytosol] (Homo sapiens)
NFATC1:CaN:CaM [cytosol] (Homo sapiens)
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Homo sapiens)
Calcineurin alpha regulatory subunit:Calcium [cytosol] (Homo sapiens)
PPP3R1 [cytosol] (Homo sapiens)
Translocation of NFATC1:CaN:CaM to nucleus (Homo sapiens)
NFATC1:CaN:CaM [cytosol] (Homo sapiens)
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Homo sapiens)
Calcineurin alpha regulatory subunit:Calcium [cytosol] (Homo sapiens)
PPP3R1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P63098 PPP3R1
Gene Names
PPP3R1, CNA2, CNB
Chain
initiator methionine:1, chain:2-170
Reference Genes
BioGPS Gene:5534 PPP3R1
CTD Gene:5534 PPP3R1
dbSNP Gene:5534 PPP3R1
ENSEMBL:ENSG00000221823 PPP3R1
ENSEMBL_homo_sapiens_GENE:ENSG00000221823 PPP3R1
HGNC:9317 PPP3R1
KEGG Gene (Homo sapiens):5534 PPP3R1
Monarch:5534 PPP3R1
NCBI Gene:5534 PPP3R1
OMIM:601302 PPP3R1
UCSC:P63098 PPP3R1
Reference Transcript
RefSeq:NM_000945.3 PPP3R1
Other Identifiers
0001050528
11728879_at
11728880_s_at
11728881_at
11747093_a_at
16898518
1AUI
1M63
1MF8
204506_at
204507_s_at
2557701
2557702
2557703
2557704
2557707
2557708
2557709
2557722
2557736
2P6B
3LL8
40513_at
47157
4F0Z
4OR9
4ORA
4ORC
5534
5610
5SVE
8052721
A_23_P108592
A_24_P388252
A_33_P3214293
AAB08721
AAH27913
AAY14715
AC017083
AK314893
BAG37407
BC027913
CAB005610
CAG33219
CCDS46310
CH471053
CR456938
D3YTA9
EAW99878
ENSG00000221823
ENSP00000234310
ENST00000234310
EntrezGene:5534
F6U1T9
g4506024_3p_a_at
GO:0002376
GO:0003674
GO:0004723
GO:0005509
GO:0005515
GO:0005516
GO:0005575
GO:0005622
GO:0005623
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0005886
GO:0005955
GO:0006464
GO:0006470
GO:0007165
GO:0007223
GO:0007267
GO:0008150
GO:0009058
GO:0016018
GO:0016020
GO:0016791
GO:0019899
GO:0019902
GO:0019904
GO:0032991
GO:0033173
GO:0034641
GO:0038095
GO:0042383
GO:0043167
GO:0043226
GO:0045944
GO:0046872
HGNC:9317
HPA047157
Hs.278540.0.A2_3p_at
ILMN_1796962
IPR002048
IPR011992
IPR018247
M30773
M30773_at
MIM:601302
NM_000945
NP_000936
PF13499
PH_hs_0032466
PPP3R1
PPP3R1-201
PR01697
SM00054
TC02005028.hg
uc002sei.2
UPI00000012AE
Participant Of
hasComponent
Calcineurin (CaN) [cytosol]
Calcineurin alpha regulatory subunit:Calcium [cytosol]
Calcineurin B complex [cytosol]
PPP3 complex [cytosol]
Other forms of this molecule
PPP3R1 [nucleoplasm]
Inferred To
Ghost homologue of PPP3R1 [cytosol] (Bos taurus)
Ghost homologue of PPP3R1 [cytosol] (Canis familiaris)
Ghost homologue of PPP3R1 [cytosol] (Danio rerio)
Ghost homologue of PPP3R1 [cytosol] (Sus scrofa)
PPP3R1 [cytosol] (Caenorhabditis elegans)
PPP3R1 [cytosol] (Dictyostelium discoideum)
PPP3R1 [cytosol] (Drosophila melanogaster)
PPP3R1 [cytosol] (Gallus gallus)
PPP3R1 [cytosol] (Plasmodium falciparum)
PPP3R1 [cytosol] (Rattus norvegicus)
PPP3R1 [cytosol] (Saccharomyces cerevisiae)
PPP3R1 [cytosol] (Schizosaccharomyces pombe)
PPP3R1 [cytosol] (Taeniopygia guttata)
PPP3R1 [cytosol] (Xenopus tropicalis)
Homologues of PPP3R1 [cytosol] (Drosophila melanogaster)
Homologues of PPP3R1 [cytosol] (Rattus norvegicus)
Ppp3r1 [cytosol] (Mus musculus)
Ppp3r1 [cytosol] (Rattus norvegicus)
Cross References
RefSeq
NP_000936.1
OpenTargets
ENSG00000221823
GeneCards
P63098
DOCK Blaster
5SVE
,
4ORA
,
4ORC
,
3LL8
,
4OR9
,
1M63
,
2P6B
,
1AUI
,
1MF8
,
4F0Z
PRO
P63098
HMDB Protein
HMDBP07550
PDB
1M63
,
5SVE
,
4ORC
,
4ORA
,
4OR9
,
1MF8
,
4F0Z
,
3LL8
,
2P6B
,
1AUI
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P24588 AKAP5
2
AKAP5 [cytosol]
(R-HSA-416331)
AKAP5 [plasma membrane]
(R-HSA-381669)
0.591
4
UniProt:P10415 BCL2
1
BCL2 [mitochondrial outer membrane]
(R-HSA-50757)
0.489
2
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