Reactome | CHRNA5 [plasma membrane]

CHRNA5 [plasma membrane]

Stable Identifier

R-HSA-507833

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Neuronal acetylcholine receptor subunit alpha-5, ACHA5_HUMAN

Locations in the PathwayBrowser

Expand all

Neuronal System (Homo sapiens)

- Transmission across Chemical Synapses (Homo sapiens)
  - Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
    - Acetylcholine binding and downstream events (Homo sapiens)
      - Postsynaptic nicotinic acetylcholine receptors (Homo sapiens)
        
        Highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Homo sapiens)
        
        Activation of highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Homo sapiens)
        
        O-acteylcholine bound to calcium permeable postsynaptic nicotinic acetylcholine receptors [plasma membrane] (Homo sapiens)
        
        Highly calcium permeable postsynaptic nicotinic acetylcholine receptors [plasma membrane] (Homo sapiens)
        
        Acetylcholine receptor containing alpha7 subunit [plasma membrane] (Homo sapiens)
        
        acetylcholine receptor subunits [plasma membrane] (Homo sapiens)
        
        CHRNA5 [plasma membrane] (Homo sapiens)
        
        Binding of acetylcholine to highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Homo sapiens)
        
        Highly calcium permeable postsynaptic nicotinic acetylcholine receptors [plasma membrane] (Homo sapiens)
        
        Acetylcholine receptor containing alpha7 subunit [plasma membrane] (Homo sapiens)
        
        acetylcholine receptor subunits [plasma membrane] (Homo sapiens)
        
        CHRNA5 [plasma membrane] (Homo sapiens)
        
        O-acteylcholine bound to calcium permeable postsynaptic nicotinic acetylcholine receptors [plasma membrane] (Homo sapiens)
        
        Highly calcium permeable postsynaptic nicotinic acetylcholine receptors [plasma membrane] (Homo sapiens)
        
        Acetylcholine receptor containing alpha7 subunit [plasma membrane] (Homo sapiens)
        
        acetylcholine receptor subunits [plasma membrane] (Homo sapiens)
        
        CHRNA5 [plasma membrane] (Homo sapiens)
      - Presynaptic nicotinic acetylcholine receptors (Homo sapiens)
        
        Highly calcium permeable nicotinic acetylcholine receptors (Homo sapiens)
        
        Activation of highly calcium permeable nicotinic acetylcholine receptors (Homo sapiens)
        
        0-acteylcholine bound to calcium permeable nictonic acteylcholine receptor complex [plasma membrane] (Homo sapiens)
        
        Highly calcium permeable nicotinic acetylcholine receptors [plasma membrane] (Homo sapiens)
        
        Acetylcholine receptor alpha3-beta2-aplha5 [plasma membrane] (Homo sapiens)
        
        CHRNA5 [plasma membrane] (Homo sapiens)
        
        Acetylcholine receptor alpha3-beta4-apha5 [plasma membrane] (Homo sapiens)
        
        CHRNA5 [plasma membrane] (Homo sapiens)
        
        Binding of acetylcholine to highly calcium permeable acetylcholine receptors (Homo sapiens)
        
        0-acteylcholine bound to calcium permeable nictonic acteylcholine receptor complex [plasma membrane] (Homo sapiens)
        
        Highly calcium permeable nicotinic acetylcholine receptors [plasma membrane] (Homo sapiens)
        
        Acetylcholine receptor alpha3-beta2-aplha5 [plasma membrane] (Homo sapiens)
        
        CHRNA5 [plasma membrane] (Homo sapiens)
        
        Acetylcholine receptor alpha3-beta4-apha5 [plasma membrane] (Homo sapiens)
        
        CHRNA5 [plasma membrane] (Homo sapiens)
        
        Highly calcium permeable nicotinic acetylcholine receptors [plasma membrane] (Homo sapiens)
        
        Acetylcholine receptor alpha3-beta2-aplha5 [plasma membrane] (Homo sapiens)
        
        CHRNA5 [plasma membrane] (Homo sapiens)
        
        Acetylcholine receptor alpha3-beta4-apha5 [plasma membrane] (Homo sapiens)
        
        CHRNA5 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P30532 CHRNA5

Gene Names

CHRNA5, NACHRA5

Chain

signal peptide:1-22, chain:23-468

Reference Genes

BioGPS Gene:1138 CHRNA5

COSMIC (genes):CHRNA5 CHRNA5

CTD Gene:1138 CHRNA5

dbSNP Gene:1138 CHRNA5

ENSEMBL:ENSG00000169684 CHRNA5

HGNC:1959 CHRNA5

KEGG:hsa:1138 CHRNA5

Monarch:1138 CHRNA5

NCBI Gene:1138 CHRNA5

OMIM:118505 CHRNA5

UCSC:P30532 CHRNA5

Reference Transcript

RefSeq:NM_000745.3 CHRNA5

Other Identifiers

1138

11735215_x_at

11735216_a_at

16803562

206533_PM_at

206533_at

3441698

3603437

3603438

3603439

3603441

3603442

3603443

3603444

3603445

3603446

3603447

3603448

3603452

3603453

3603455

36397_at

7985213

A_23_P88691

GE59289

GO:0004888

GO:0005215

GO:0005216

GO:0005230

GO:0005515

GO:0005886

GO:0005892

GO:0006811

GO:0007154

GO:0007165

GO:0007268

GO:0007271

GO:0015276

GO:0015464

GO:0016020

GO:0022848

GO:0023052

GO:0034220

GO:0035094

GO:0035095

GO:0043005

GO:0045202

GO:0045211

GO:0051899

GO:0055085

GO:0060078

GO:0060079

GO:0060089

GO:0095500

GO:0098691

GO:0098793

GO:0098981

GO:0099171

HMNXSV003007291

ILMN_1770044

ILMN_2110751

M83712_s_at

PH_hs_0000221

TC15000732.hg

U62434_at

g4502828_3p_at

Participates

as a member of

acetylcholine receptor subunits [plasma membrane] (Homo sapiens)

as a component of

Inferred To

Chrna5 [plasma membrane] (Mus musculus)

Chrna5 [plasma membrane] (Rattus norvegicus)

acr-12 [plasma membrane] (Caenorhabditis elegans)

unc-63 [plasma membrane] (Caenorhabditis elegans)

CHRNA5 [plasma membrane] (Bos taurus)

CHRNA5 [plasma membrane] (Canis familiaris)

CHRNA5 [plasma membrane] (Gallus gallus)

CHRNA5 [plasma membrane] (Sus scrofa)

Homologues of CHRNA5 [plasma membrane] (Caenorhabditis elegans)

Homologues of CHRNA5 [plasma membrane] (Drosophila melanogaster)

acr-8 [plasma membrane] (Caenorhabditis elegans)

lev-1 [plasma membrane] (Caenorhabditis elegans)

nAChRalpha2 [plasma membrane] (Drosophila melanogaster)

nAChRalpha3 [plasma membrane] (Drosophila melanogaster)

unc-29 [plasma membrane] (Caenorhabditis elegans)

acr-3 [plasma membrane] (Caenorhabditis elegans)

nAChRalpha4 [plasma membrane] (Drosophila melanogaster)

acr-6 [plasma membrane] (Caenorhabditis elegans)

chrna5 [plasma membrane] (Danio rerio)

chrna5 [plasma membrane] (Xenopus tropicalis)

nAChRbeta2 [plasma membrane] (Drosophila melanogaster)

acr-2 [plasma membrane] (Caenorhabditis elegans)

lev-8 [plasma membrane] (Caenorhabditis elegans)

nAChRalpha1 [plasma membrane] (Drosophila melanogaster)

nAChRbeta1 [plasma membrane] (Drosophila melanogaster)

unc-38 [plasma membrane] (Caenorhabditis elegans)

Cross References

Guide to Pharmacology - Targets

466

ENSEMBL

ENSP00000299565, ENST00000299565, ENSG00000169684

OpenTargets

ENSG00000169684

GeneCards

CHRNA5

HPA

ENSG00000169684-CHRNA5

PRO

P30532

Pharos - Targets

P30532

GlyGen

P30532

HMDB Protein

HMDBP12045

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P59665 DEFA1	9	DEFA1(1-94) [Golgi lumen] (R-HSA-1467215) DEFA1(20-94) [Golgi lumen] (R-HSA-1467282) DEFA1(66-94) [Golgi lumen] (R-HSA-975663) DEFA1(20-65) [Golgi lumen] (R-HSA-8864970) DEFA1(66-94) [extracellular region] (R-HSA-1461998) DEFA1(66-94) [azurophil granule lumen] (R-HSA-1470038) DEFA1(65-94) [extracellular region] (R-HSA-1462022) omega-N-(ADP-ribosyl)-L-arginine-DEFA1(65-94) [extracellular region] (R-HSA-1972397) DEFA1(65-94) [azurophil granule lumen] (R-HSA-1470053)	0.527	2