LIN28:POU5F1 mRNA

Stable Identifier
R-HSA-500373
Type
Complex
Species
Homo sapiens
Compartment
Synonyms
LIN28:OCT4 mRNA
Locations in the PathwayBrowser
Summation

LIN28 binds the R2 region of the POU5F1 (OCT4) mRNA and increases translation of a luciferase reporter mRNA containing the binding site (Qiu et al. 2009, Lei et al. 2012). Reduction of LIN28 levels in embryonic stem cells causes a reduction in POU5F1 protein (Qiu et al. 2009).

Literature References
PubMed ID Title Journal Year
19966271 Lin28-mediated post-transcriptional regulation of Oct4 expression in human embryonic stem cells

Qiu, C, Ma, Y, Wang, J, Peng, S, Huang, Y

Nucleic Acids Res 2009
Participants
Participant Of
This entity regulates
Inferred To