Translation of OCT4 mRNA

Stable Identifier
R-HSA-2889036
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol, nucleoplasm
ReviewStatus
5/5
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Translation of OCT4 mRNA
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LIN28 binds the R2 region of OCT4 (POU5F1) mRNA and increases translation.

The POU5F1 (OCT4) mRNA is translated to yield protein. LIN28 bound to the mRNA appears to enhance translation (Qiu et al. 2009, Lei et al. 2012).

Literature References
PubMed ID Title Journal Year
19966271 Lin28-mediated post-transcriptional regulation of Oct4 expression in human embryonic stem cells

Peng, S, Huang, Y, Qiu, C, Wang, J, Ma, Y

Nucleic Acids Res 2009
22210884 Determinants of mRNA recognition and translation regulation by Lin28

Qiao, C, Lei, XX, Hammond, SM, Huang, Y, Newman, MA, Ma, W, Xu, J

Nucleic Acids Res. 2012
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
LIN28:POU5F1 mRNA [cytosol] (Homo sapiens)
Active Unit
LIN28A [cytosol]
Authored
May, B  (2012-12-30)
Reviewed
Wang, J  (2014-01-23)
Created
May, B  (2012-12-31)
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