(d)NTP + ADP <=> (d)NDP + ATP (NME4)

Stable Identifier
Reaction [transition]
Homo sapiens
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Nucleoside diphosphate kinase NME4 associated with the inner mitochondrial membrane (Tokarska-Schlattner et al. 2008) catalyzes the reversible reaction of ribonucleoside and deoxyribonucleoside 5'-diphosphates with ADP to form the corresponding nucleoside 5'-diphosphates and ATP. The active form of the enzyme is a hexamer of NME4 polypeptides whose amino-terminal 33 residues, a mitochondrial translocation signal, have been removed (Milon et al. 2000). The substrate specificity of NME4 has not been examined in detail, but is inferred to be broad like that of the homologous NME1, 2, and 3 kinases (Schaertl et al. 1998).
Literature References
PubMed ID Title Journal Year
18635542 The nucleoside diphosphate kinase D (NM23-H4) binds the inner mitochondrial membrane with high affinity to cardiolipin and couples nucleotide transfer with respiration

Munier, A, Mailleau, C, Lacombe, ML, Speer, O, Borot, C, Boissan, M, Tokarska-Schlattner, M, Schlattner, U

J Biol Chem 2008
9488696 Substrate specificity of human nucleoside-diphosphate kinase revealed by transient kinetic analysis

Konrad, M, Geeves, MA, Schaertl, S

J Biol Chem 1998
10799505 The human nm23-H4 gene product is a mitochondrial nucleoside diphosphate kinase

Janin, J, Capeau, J, Milon, L, Munier, A, Lacombe, ML, Karlsson, A, Lascu, I, Meyer, P, Johansson, M, Chiadmi, M

J Biol Chem 2000
Catalyst Activity

nucleoside diphosphate kinase activity of NME4 hexamer [mitochondrial inner membrane]

Orthologous Events
Cross References
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