Reactome | (d)NDP + ATP <=> (d)NTP + ADP (NME4)

(d)NDP + ATP <=> (d)NTP + ADP (NME4)

Stable Identifier

R-HSA-482804

Type

Reaction [transition]

Species

Homo sapiens

Compartment

mitochondrial matrix, mitochondrial inner membrane

ReviewStatus

5/5

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Nucleoside diphosphate kinase NME4 associated with the inner mitochondrial membrane (Tokarska-Schlattner et al. 2008) catalyzes the reversible reaction of ribonucleoside and deoxyribonucleoside 5'-diphosphates with ATP to form the corresponding nucleoside 5'-triphosphates and ADP. The active form of the enzyme is a hexamer of NME4 polypeptides whose amino-terminal 33 residues, a mitochondrial translocation signal, have been removed (Milon et al. 2000). The substrate specificity of NME4 has not been examined in detail but is inferred to be broad like that of the homologous NME1, 2, and 3 kinases (Schaertl et al. 1998).

Literature References

PubMed ID	Title	Journal	Year
18635542	The nucleoside diphosphate kinase D (NM23-H4) binds the inner mitochondrial membrane with high affinity to cardiolipin and couples nucleotide transfer with respiration Tokarska-Schlattner, M, Boissan, M, Munier, A, Borot, C, Mailleau, C, Speer, O, Schlattner, U, Lacombe, ML	J Biol Chem	2008
9488696	Substrate specificity of human nucleoside-diphosphate kinase revealed by transient kinetic analysis Schaertl, S, Konrad, M, Geeves, MA	J Biol Chem	1998
10799505	The human nm23-H4 gene product is a mitochondrial nucleoside diphosphate kinase Milon, L, Meyer, P, Chiadmi, M, Munier, A, Johansson, M, Karlsson, A, Lascu, I, Capeau, J, Janin, J, Lacombe, ML	J Biol Chem	2000