Reactome | WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C) methylate lysine-37 of histone H3 (H3K36)

WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C) methylate lysine-37 of histone H3 (H3K36)

Stable Identifier

R-HSA-4827383

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

WHSC1, NSD1, SMYD2 methylate lysine-37 of histone H3

ReviewStatus

5/5

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WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C) methylate lysine-37 of histone H3 (H3K36)

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Methylation of histone H3 lysine-37 (H3K36) is tightly associated with actively transcribed genes and appears to correspond primarily with coding regions (Wagner & Carpenter 2011).

WHSC1 (KMT3G, NSD2, MMSET), a member of the SET2 family, dimethylates H3K36 when provided with nucleosome substrates (Li et al 2009; Qiao et al. 2011). Dimethylation of histone H3 at lysine-37 (H3K36me2) is thought to be the principal chromatin-regulatory activity of WHSC1 (Kuo et al. 2011), SMYD2 (KMT3C) (Brown et al 2006) and NSD1 (KMT3B) (Li et al. 2009, Qiao et al. 2011).

Literature References

PubMed ID	Title	Journal	Year
16805913	Identification and characterization of Smyd2: a split SET/MYND domain-containing histone H3 lysine 36-specific methyltransferase that interacts with the Sin3 histone deacetylase complex Brown, MA, Tucker, PW, Gottlieb, PD, Sims, RJ	Mol. Cancer	2006
22099308	NSD2 links dimethylation of histone H3 at lysine 36 to oncogenic programming Garcia, BA, Lauring, J, Chen, K, Park, BH, Zee, BM, Li, W, Gozani, O, Kioi, M, Cheung, P, Shi, X, Xi, Y, Kuo, AJ	Mol. Cell	2011
19808676	The target of the NSD family of histone lysine methyltransferases depends on the nature of the substrate Xu, CF, Trojer, P, Qiao, Q, Reinberg, D, Drury, WJ, Li, Y, Xu, RM, Gozani, O, Cheung, P, Kuo, A, Neubert, TA	J. Biol. Chem.	2009
21196496	The structure of NSD1 reveals an autoregulatory mechanism underlying histone H3K36 methylation Qiao, Q, Reinberg, D, Chen, Z, Wang, M, Li, Y, Xu, RM	J. Biol. Chem.	2011