TOPORS SUMOylates IKBKE with SUMO1

Stable Identifier
R-HSA-4755478
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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TOPORS SUMOylates IKBKE with SUMO1
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TOPORS SUMOylates phosphorylated IKBKE (IKKI, IKKE) with SUMO1 at lysine-231 (Renner et al. 2010). SUMOylation causes IKBKE to localize with PML in the nucleus and is required for IKBKE to trigger phosphorylation of NF-kappaB p65.

Literature References
Participants
Input
Output
Participates
as an event of
Catalyst Activity

SUMO transferase activity of TOPORS [nucleoplasm]

Physical Entity
TOPORS [nucleoplasm] (Homo sapiens)
Activity
SUMO transferase activity (GO:0019789)
Orthologous Events
TOPORS SUMOylates IKBKE with SUMO1 (Bos taurus)
TOPORS SUMOylates IKBKE with SUMO1 (Danio rerio)
TOPORS SUMOylates IKBKE with SUMO1 (Gallus gallus)
TOPORS SUMOylates IKBKE with SUMO1 (Mus musculus)
TOPORS SUMOylates IKBKE with SUMO1 (Rattus norvegicus)
Authored
May, B  (2013-10-20)
Reviewed
Niskanen, E  (2018-05-09)
Niskanen, E  (2018-08-08)
Created
May, B  (2013-10-25)
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