TOPORS SUMOylates IKBKE with SUMO1

Stable Identifier
R-HSA-4755478
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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TOPORS SUMOylates phosphorylated IKBKE (IKKI, IKKE) with SUMO1 at lysine-231 (Renner et al. 2010). SUMOylation causes IKBKE to localize with PML in the nucleus and is required for IKBKE to trigger phosphorylation of NF-kappaB p65.
Literature References
Participants
Participates
Catalyst Activity

SUMO transferase activity of TOPORS [nucleoplasm]

Orthologous Events
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