SUMOylation of immune response proteins

Stable Identifier
R-HSA-4755510
DOI
10.3180/R-HSA-4755510.2
Type
Pathway
Species
Homo sapiens
Compartment
nucleoplasm, cytosol
ReviewStatus
4/5
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SUMOylation of immune response proteins
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NF-kappaB transcription factors are sequestered in the cytosol due to their association with IkappaB. During activation of NF-kappaB, IKK phosphorylates IkappaB, releasing NF-kappaB for importation into the nucleus. NF-kappaB transcription factors, the NFKBIA component of IkappaB, and subunits of the IKK complex can be SUMOylated (reviewed in Kracklauer and Schmidt 2003, Liu et al. 2013). SUMOylations of IkappaB, NFKBIA, and RELA inhibit NF-kappaB signaling; SUMOylation of NFKB2 is required for proteolytic processing.
Literature References
PubMed ID Title Journal Year
14613580 At the crossroads of SUMO and NF-kappaB

Schmidt, C, Kracklauer, MP

Mol. Cancer 2003
23953672 Dynamic regulation of innate immunity by ubiquitin and ubiquitin-like proteins

Chen, W, Wang, C, Wang, Q, Liu, X

Cytokine Growth Factor Rev. 2013
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Orthologous Events
SUMOylation of immune response proteins (Bos taurus)
SUMOylation of immune response proteins (Danio rerio)
SUMOylation of immune response proteins (Drosophila melanogaster)
SUMOylation of immune response proteins (Gallus gallus)
SUMOylation of immune response proteins (Mus musculus)
SUMOylation of immune response proteins (Rattus norvegicus)
SUMOylation of immune response proteins (Sus scrofa)
SUMOylation of immune response proteins (Xenopus tropicalis)
Authored
May, B  (2013-10-20)
Reviewed
Niskanen, E  (2018-05-09)
Niskanen, E  (2018-08-08)
Created
May, B  (2013-10-25)
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