Reactome | PAXIP1:PAGR1 complex, NCOA6 and KDM6A bind MLL4 complex

PAXIP1:PAGR1 complex, NCOA6 and KDM6A bind MLL4 complex

Stable Identifier

R-HSA-9821410

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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PAXIP1:PAGR1 complex, NCOA6 and KDM6A bind MLL4 complex

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The MLL4 complex (KMT2D:WRAD, where the WRAD subcomplex consists of ASH2L, DPY30, RBBP5, and WDR5) associates with several accessory proteins that act as transcriptional cofactors: the complex of PAXIP1 (also known as PTIP) and PAGR1 (also known as PA1), NCOA6 (also known as ASC-2), and KDM6A (also known as UTX) proteins. The existence of the complex of MLL4, PAXIP1, PAGR1, NCOA6 and KDM6A, named MLL4-ASCOM, was established by co-immunoprecipitation of endogenous proteins from mouse and human cells and by functional studies (Cho et al. 2007; Patel et al. 2007; van Nuland et al. 2013; reviewed in Liu and Li 2022). The complex of PAXIP1 and PAGR1 enables the recruitment of the MLL4 complex to PAX2 target genes (Patel et al. 2007). While the complex of PAXIP1 and PAGR1 seems to be an obligatory constituent of the MLL4 complex, not every complex of PAXIP1, PAGR1 and MLL4 contains NCOA6 and KDM6A (van Nuland et al. 2013).

Literature References

PubMed ID	Title	Journal	Year
23508102	Quantitative dissection and stoichiometry determination of the human SET1/MLL histone methyltransferase complexes Pallaki, P, Smits, AH, van Nuland, R, Jansen, PW, Timmers, HT, Vermeulen, M	Mol Cell Biol	2013
17500065	PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex Ge, K, Guo, H, Hong, S, Hong, T, Yu, H, Copeland, TD, Kim, D, Dressler, GR, Guszczynski, T, Cho, YW, Kalkum, M	J. Biol. Chem.	2007
17925232	The BRCT-domain containing protein PTIP links PAX2 to a histone H3, lysine 4 methyltransferase complex Levitan, I, Kim, D, Dressler, GR, Patel, SR	Dev Cell	2007