PIAS1 SUMOylates NR2C1 (TR2)

Stable Identifier
R-HSA-4717521
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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PIAS1 SUMOylates NR2C1 (TR2)
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As inferred from mouse homologs, PIAS1 SUMOylates NR2C1 (TR2) with SUMO1 at lysine-250. UnSUMOylated NR2C1 is localized to PML bodies and activates expression of OCT4. SUMOylated NR2C1 delocalizes from PML bodies and acts as a repressor of transcription.

Participants
Input
Output
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as an event of
Catalyst Activity

SUMO transferase activity of PIAS1 [nucleoplasm]

Physical Entity
PIAS1 [nucleoplasm] (Homo sapiens)
Activity
SUMO transferase activity (GO:0019789)
Inferred From
Pias1 Sumoylates Nr2c1 (Tr2) (Mus musculus)
Authored
May, B  (2013-10-11)
Reviewed
Niskanen, E  (2018-05-09)
Niskanen, E  (2018-08-08)
Created
May, B  (2013-10-18)
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