PIAS1 SUMOylates NR2C1 (TR2)

Stable Identifier
R-HSA-4717521
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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As inferred from mouse homologs, PIAS1 SUMOylates NR2C1 (TR2) with SUMO1 at lysine-250. UnSUMOylated NR2C1 is localized to PML bodies and activates expression of OCT4. SUMOylated NR2C1 delocalizes from PML bodies and acts as a repressor of transcription.

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
SUMO transferase activity of PIAS1 [nucleoplasm]
Physical Entity
Activity
Inferred From
Authored
Reviewed
Created
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