SUMOylation of DNMT3B with SUMO1

Stable Identifier
R-HSA-4655374
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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SUMOylation of DNMT3B with SUMO1
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DNMT3B is SUMOylated with SUMO1 at unknown lysine residues (Kang et al. 2001, Park et al. 2008). SUMOylation relieves transcriptional repression by DNMT3B.
Literature References
PubMed ID Title Journal Year
11735126 Dnmt3b, de novo DNA methyltransferase, interacts with SUMO-1 and Ubc9 through its N-terminal region and is subject to modification by SUMO-1

Kang, ES, Park, CW, Chung, JH

Biochem. Biophys. Res. Commun. 2001
18762900 DNA methyltransferase 3B mutant in ICF syndrome interacts non-covalently with SUMO-1

Park, J, Kim, TY, Jung, Y, Song, SH, Kim, SH, Oh, DY, Im, SA, Bang, YJ

J. Mol. Med. 2008
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Catalyst Activity

SUMO transferase activity of SUMO1:C93-UBE2I [nucleoplasm]

Physical Entity
SUMO1:C93-UBE2I [nucleoplasm] (Homo sapiens)
Activity
SUMO transferase activity (GO:0019789)
Orthologous Events
SUMOylation of DNMT3B with SUMO1 (Bos taurus)
SUMOylation of DNMT3B with SUMO1 (Danio rerio)
SUMOylation of DNMT3B with SUMO1 (Gallus gallus)
SUMOylation of DNMT3B with SUMO1 (Mus musculus)
SUMOylation of DNMT3B with SUMO1 (Rattus norvegicus)
SUMOylation of DNMT3B with SUMO1 (Sus scrofa)
Authored
May, B  (2013-09-28)
Reviewed
Niskanen, E  (2018-05-09)
Niskanen, E  (2018-08-08)
Created
May, B  (2013-10-03)
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