SUMOylation of DNMT3B with SUMO1

Stable Identifier
R-HSA-4655374
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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DNMT3B is SUMOylated with SUMO1 at unknown lysine residues (Kang et al. 2001, Park et al. 2008). SUMOylation relieves transcriptional repression by DNMT3B.

Literature References
PubMed ID Title Journal Year
18762900 DNA methyltransferase 3B mutant in ICF syndrome interacts non-covalently with SUMO-1

Park, J, Kim, TY, Jung, Y, Song, SH, Kim, SH, Oh, DY, Im, SA, Bang, YJ

J. Mol. Med. 2008
11735126 Dnmt3b, de novo DNA methyltransferase, interacts with SUMO-1 and Ubc9 through its N-terminal region and is subject to modification by SUMO-1

Kang, ES, Park, CW, Chung, JH

Biochem. Biophys. Res. Commun. 2001
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
SUMO transferase activity of SUMO1:C93-UBE2I [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created