SUMOylation of DNA methylation proteins

Stable Identifier
R-HSA-4655427
DOI
10.3180/R-HSA-4655427.2
Type
Pathway
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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SUMOylation of DNA methylation proteins
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The known DNA methyltransferases (DNMT1, DNMT3A, and DNMT3B) can be SUMOylated (reviewed in Xu et al. 2010, Denis et al. 2011). SUMOylation affects the catalytic activity of DNMT1 and the protein interactions of DNMT3A.
Literature References
PubMed ID Title Journal Year
20939822 Molecular and enzymatic profiles of mammalian DNA methyltransferases: structures and targets for drugs

Zhang, L, Wu, L, Shi, A, Xu, Z, Ding, Y, Zhang, H, Rui, C, Mao, C, Xu, F

Curr. Med. Chem. 2010
21660058 Regulation of mammalian DNA methyltransferases: a route to new mechanisms

Fuks, F, Ndlovu, MN, Denis, H

EMBO Rep. 2011
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Orthologous Events
SUMOylation of DNA methylation proteins (Bos taurus)
SUMOylation of DNA methylation proteins (Danio rerio)
SUMOylation of DNA methylation proteins (Gallus gallus)
SUMOylation of DNA methylation proteins (Mus musculus)
SUMOylation of DNA methylation proteins (Rattus norvegicus)
SUMOylation of DNA methylation proteins (Sus scrofa)
SUMOylation of DNA methylation proteins (Xenopus tropicalis)
Authored
May, B  (2013-09-28)
Reviewed
Niskanen, E  (2018-05-09)
Niskanen, E  (2018-08-08)
Created
May, B  (2013-10-03)
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