Reactome | SMURF1/2 ubiquitinates PRICKLE1

SMURF1/2 ubiquitinates PRICKLE1

Stable Identifier

R-HSA-4608852

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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PRICKLE1 is a conserved PCP protein with a localization pattern opposite to that of DVL. PRICKLE1 is recruited to the PARD6A:ppDVL2:SMURF complex through its interaction with DVL and is subsequently ubiquitinated by the E3 ligase activity of SMURF (Narimatsu et al, 2009; Jenny et al, 2005). This leads to localized degradation of PRICKLE1, contributing to its asymmetrical localization (Narimatsu et al, 2009). Note that in this reaction the interaction between PRICKLE1 and DVL is not shown.

Literature References

PubMed ID	Title	Journal	Year
15937478	Diego and Prickle regulate Frizzled planar cell polarity signalling by competing for Dishevelled binding Jenny, A, Reynolds-Kenneally, J, Das, G, Burnett, M, Mlodzik, M	Nat Cell Biol	2005
19379695	Regulation of planar cell polarity by Smurf ubiquitin ligases Narimatsu, M, Bose, R, Pye, M, Zhang, L, Miller, B, Ching, P, Sakuma, R, Luga, V, Roncari, L, Attisano, L, Wrana, JL	Cell	2009