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ub-PRICKLE1 [cytosol]
Stable Identifier
R-HSA-4608820
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
RILP
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by WNT (Homo sapiens)
Beta-catenin independent WNT signaling (Homo sapiens)
PCP/CE pathway (Homo sapiens)
Asymmetric localization of PCP proteins (Homo sapiens)
PRICKLE1 is degraded by the proteasome (Homo sapiens)
ub-PRICKLE1 [cytosol] (Homo sapiens)
SMURF1/2 ubiquitinates PRICKLE1 (Homo sapiens)
ub-PRICKLE1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q96MT3 PRICKLE1
Gene Names
PRICKLE1, RILP
Chain
chain:1-828, propeptide:829-831
Reference Genes
BioGPS Gene:144165 PRICKLE1
COSMIC (genes):PRICKLE1 PRICKLE1
CTD Gene:144165 PRICKLE1
dbSNP Gene:144165 PRICKLE1
ENSEMBL:ENSG00000139174 PRICKLE1
ENSEMBL_homo_sapiens_GENE:ENSG00000139174.12 PRICKLE1
HGNC:17019 PRICKLE1
KEGG Gene (Homo sapiens):144165 PRICKLE1
Monarch:144165 PRICKLE1
NCBI Gene:144165 PRICKLE1
OMIM:608500 PRICKLE1
UCSC:Q96MT3 PRICKLE1
Reference Transcript
RefSeq:XM_011537946.1 PRICKLE1
RefSeq:XM_017018840.1 PRICKLE1
RefSeq:XM_017018839.1 PRICKLE1
RefSeq:XM_017018838.1 PRICKLE1
RefSeq:NM_001144882.1 PRICKLE1
RefSeq:NM_001144881.1 PRICKLE1
RefSeq:NM_153026.2 PRICKLE1
RefSeq:NM_001144883.1 PRICKLE1
RefSeq:XM_011537947.2 PRICKLE1
Other Identifiers
11727150_a_at
11727151_a_at
11727152_s_at
144165
16763295
226065_PM_at
226065_at
226069_PM_at
226069_at
230708_PM_at
230708_at
232811_3p_x_at
232811_PM_x_at
232811_x_at
3451368
3451376
3451377
3451378
3451379
3451380
3451381
3451382
3451383
3451384
3451387
3451388
3451389
3451391
3451392
3451393
3451394
3451395
54071_at
54324_at
7962375
A_23_P408285
GE87283
GO:0000278
GO:0000502
GO:0001843
GO:0001894
GO:0003151
GO:0003402
GO:0005515
GO:0005634
GO:0005635
GO:0005737
GO:0005829
GO:0006351
GO:0006355
GO:0006606
GO:0006886
GO:0006913
GO:0006915
GO:0007010
GO:0007059
GO:0007155
GO:0007163
GO:0007173
GO:0007409
GO:0007507
GO:0008270
GO:0009410
GO:0009887
GO:0009888
GO:0010467
GO:0012501
GO:0016020
GO:0016043
GO:0016055
GO:0016192
GO:0016358
GO:0016477
GO:0023052
GO:0030010
GO:0030154
GO:0030163
GO:0030198
GO:0030282
GO:0030326
GO:0030705
GO:0031175
GO:0031254
GO:0031398
GO:0031965
GO:0032436
GO:0034330
GO:0035108
GO:0035264
GO:0035880
GO:0035904
GO:0036211
GO:0036342
GO:0042733
GO:0043226
GO:0044782
GO:0044877
GO:0045184
GO:0045892
GO:0046872
GO:0048812
GO:0048856
GO:0048870
GO:0051602
GO:0055013
GO:0060071
GO:0060173
GO:0060271
GO:0060325
GO:0060485
GO:0060976
GO:0061029
GO:0061159
GO:0061303
GO:0061326
GO:0061865
GO:0070075
GO:0071711
GO:0085029
GO:0090009
GO:0090090
GO:0090307
GO:0098609
GO:0120181
GO:0140014
GO:1905070
GO:1990138
GO:1990403
GO:2000691
HMNXSV003036674
Hs.229084.0.A1_3p_at
Hs.229084.0.A1_3p_x_at
Hs.6786.0.A1_3p_at
Hs.6786.0.A2_3p_at
Hs.86237.0.A1_3p_at
ILMN_1741356
PH_hs_0000682
TC12001405.hg
TC12002841.hg
p25818
Participates
as an output of
SMURF1/2 ubiquitinates PRICKLE1 (Homo sapiens)
as an input of
PRICKLE1 is degraded by the proteasome (Homo sapiens)
Other forms of this molecule
PRICKLE1 [cytosol]
Inferred To
prickle1a [cytosol]
(Danio rerio)
PRICKLE1 [cytosol]
(Bos taurus)
PRICKLE1 [cytosol]
(Canis familiaris)
PRICKLE1 [cytosol]
(Gallus gallus)
PRICKLE1 [cytosol]
(Sus scrofa)
prickle1 [cytosol]
(Xenopus tropicalis)
prkl-1 [cytosol]
(Caenorhabditis elegans)
Prickle1 [cytosol]
(Mus musculus)
Prickle1 [cytosol]
(Rattus norvegicus)
pk [cytosol]
(Drosophila melanogaster)
Modified Residues
Name
ubiquitinylated lysine (K48polyUb [cytosol]) at unknown position
Modification
K48polyUb [cytosol]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Cross References
RefSeq
XP_011536249.1
,
XP_016874328.1
,
NP_001138354.1
,
XP_016874329.1
,
NP_001138355.1
,
XP_016874327.1
,
NP_001138353.1
,
NP_694571.2
,
XP_011536248.1
OpenTargets
ENSG00000139174
GeneCards
Q96MT3
HPA
ENSG00000139174-PRICKLE1
Ensembl
ENSP00000492332
,
ENST00000639566
,
ENSP00000398947
,
ENST00000639958
,
ENSP00000345064
,
ENST00000548696
,
ENSP00000449819
,
ENST00000345127
,
ENST00000639589
,
ENSP00000492644
,
ENSP00000492763
,
ENST00000552240
,
ENST00000640132
,
ENST00000640055
,
ENST00000445766
,
ENST00000455697
,
ENSG00000139174
,
ENSP00000491051
,
ENSP00000491228
,
ENSP00000401060
,
ENSP00000448359
PRO
Q96MT3
Pharos - Targets
Q96MT3
Orphanet
17886
HMDB Protein
HMDBP12748
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q8WWY3 PRPF31
1
PRPF31 [nucleoplasm]
(R-HSA-6806772)
0.718
6
UniProt:Q8VIG1
1
Rest [nucleoplasm]
(R-MMU-480506)
0.589
4
UniProt:Q08E77 Q08E77
0.556
3
UniProt:Q9HAQ2 KIF9
1
KIF9 [cytosol]
(R-HSA-984616)
0.556
3
UniProt:O75564-2 O755642
0.556
3
UniProt:Q13895 BYSL
2
BYSL [nucleoplasm]
(R-HSA-6791526)
BYSL [cytosol]
(R-HSA-6791518)
0.556
3
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