PRICKLE1 is degraded by the proteasome

Stable Identifier
R-HSA-4608855
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
PRICKLE1 is degraded by the proteasome
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Localized degradation of ub-PRICKLE1 contributes to asymmetric localization of the protein (Narimatsu et al, 2009).

Literature References
PubMed ID Title Journal Year
19379695 Regulation of planar cell polarity by Smurf ubiquitin ligases

Narimatsu, M, Bose, R, Pye, M, Zhang, L, Miller, B, Ching, P, Sakuma, R, Luga, V, Roncari, L, Attisano, L, Wrana, JL

Cell 2009
Participants
Input
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
endopeptidase activity of 26S proteasome [cytosol]
Physical Entity
26S proteasome [cytosol]
Activity
endopeptidase activity (0004175)
Orthologous Events
PRICKLE1 is degraded by the proteasome (Bos taurus)
PRICKLE1 is degraded by the proteasome (Caenorhabditis elegans)
PRICKLE1 is degraded by the proteasome (Canis familiaris)
PRICKLE1 is degraded by the proteasome (Danio rerio)
PRICKLE1 is degraded by the proteasome (Drosophila melanogaster)
PRICKLE1 is degraded by the proteasome (Mus musculus)
PRICKLE1 is degraded by the proteasome (Rattus norvegicus)
PRICKLE1 is degraded by the proteasome (Sus scrofa)
PRICKLE1 is degraded by the proteasome (Xenopus tropicalis)
Authored
Rothfels, K  (2013-09-19)
Reviewed
Kikuchi, A  (2013-11-13)
Created
Rothfels, K  (2013-09-23)