Wnt5a binds Ror2 and Vangl2

Stable Identifier
R-MMU-4551566
Type
Reaction
Species
Mus musculus
Compartment
General
SVG |   | PPTX  | SBGN
Wnt5a binds Ror2 and Vangl2

Ror2 and Vangl2 form a complex in mouse limb buds in a Wnt5a-dependent manner. Formation of this complex regulates Vangl2 phosphorylation and is required to initiate the asymmetrical protein distributions that characterize the PCP pathway (Gao et al, 2011).

Literature References
PubMed ID Title Journal Year
21316585 Wnt signaling gradients establish planar cell polarity by inducing Vangl2 phosphorylation through Ror2

Gao, B, Song, H, Bishop, K, Elliot, G, Garrett, L, English, MA, Andre, P, Robinson, J, Sood, R, Minami, Y, Economides, AN, Yang, Y

Dev. Cell 2011
Participants
Orthologous Events
Authored
Reviewed
Created