Reactome | IL2RG binds JAK3

IL2RG binds JAK3

Stable Identifier

R-HSA-451895

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

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Cytokine receptor common gamma subunit (IL2RG, IL-2 receptor gamma chain, Gc) associates with Tyrosine-protein kinase JAK3 (JAK3). The carboxyl-terminal region of IL2RG is important for this association (Miyazaki et al. 1994, Zhu et al. 1998, Russel et al. 2004, Chen et al.1997, Nelson et al.1994) as well as the FERM domain in JAK3 (Zhou et al. 2001).

Literature References

PubMed ID	Title	Journal	Year
7514277	Cytoplasmic domains of the interleukin-2 receptor beta and gamma chains mediate the signal for T-cell proliferation Nelson, BH, Lord, JD, Greenberg, PD	Nature	1994
9553136	Delineation of the regions of interleukin-2 (IL-2) receptor beta chain important for association of Jak1 and Jak3. Jak1-independent functional recruitment of Jak3 to Il-2Rbeta Zhu, MH, Berry, JA, Russell, SM, Leonard, WJ	J Biol Chem	1998

Participants

Input

Output

IL2RG:JAK3 [plasma membrane] (Homo sapiens)

Participant Of

hasEvent

Orthologous Events

IL2RG binds JAK3 (Bos taurus)

IL2RG binds JAK3 (Canis familiaris)

IL2RG binds JAK3 (Gallus gallus)

IL2RG binds JAK3 (Mus musculus)

IL2RG binds JAK3 (Rattus norvegicus)

IL2RG binds JAK3 (Sus scrofa)

Authored

Ray, KP (2010-05-17)

Reviewed

Meldal, BH (2016-01-28)

Limon, PL (2018-04-27)

Created

Jupe, S (2010-01-14)