KSRP binds to AU-rich sequences in the 3' untranslated regions of mRNAs. KSRP causes the bound mRNA to be targeted for hydrolysis by recruiting exonucleases and decapping enzymes. The activity of KSRP is regulated by phosphorylation. Protein kinase B/Akt phosphorylates KSRP at serine193. The phosphorylation inhibits the ability of KSRP to destabilize mRNA. KSRP phosphorylated at serine193 binds 14-3-3zeta (YWHAZ) which causes KSRP to be retained in the nucleus.
Barreau, C, Paillard, L, Osborne, HB
Ceriani, MC, Bevilacqua, A, Capaccioli, S, Nicolin, A
Kruys, V, Zhang, T, Huez, G, Gueydan, C
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