Reactome | KSRP (KHSRP) binds and destabilizes mRNA

KSRP (KHSRP) binds and destabilizes mRNA

Stable Identifier

R-HSA-450604

Type

Pathway

Species

Homo sapiens

Compartment

cytosol, nucleoplasm

ReviewStatus

5/5

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KSRP (KHSRP) binds and destabilizes mRNA

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KSRP binds to AU-rich sequences in the 3' untranslated regions of mRNAs. KSRP causes the bound mRNA to be targeted for hydrolysis by recruiting exonucleases and decapping enzymes. The activity of KSRP is regulated by phosphorylation. Protein kinase B/Akt phosphorylates KSRP at serine193. The phosphorylation inhibits the ability of KSRP to destabilize mRNA. KSRP phosphorylated at serine193 binds 14-3-3zeta (YWHAZ) which causes KSRP to be retained in the nucleus.

Literature References

PubMed ID	Title	Journal	Year
16391004	AU-rich elements and associated factors: are there unifying principles? Barreau, C, Paillard, L, Osborne, HB	Nucleic Acids Res	2005
12704645	Post-transcriptional regulation of gene expression by degradation of messenger RNAs Ceriani, MC, Bevilacqua, A, Capaccioli, S, Nicolin, A	J Cell Physiol	2003
12440953	AU-rich element-mediated translational control: complexity and multiple activities of trans-activating factors Kruys, V, Zhang, T, Huez, G, Gueydan, C	Biochem Soc Trans	2002