Reactome | Activated chicken TRAF6 synthesizes free K63bound poly_Ub chains within the complex dsRNA :TLR3 :TICAM1

Activated chicken TRAF6 synthesizes free K63bound poly_Ub chains within the complex dsRNA :TLR3 :TICAM1

Stable Identifier

R-GGA-433936

Type

Reaction [omitted]

Species

Gallus gallus

Related Species

Infectious bronchitis virus

Compartment

cytosol, endosome membrane

ReviewStatus

5/5

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Activated chicken TRAF6 synthesizes free K63bound poly_Ub chains within the complex dsRNA :TLR3 :TICAM1

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TRAF6 generates unanchored Lys63-linked polyubiquitin chains that bind to the regulatory subunits of the TAK1 (TAB2 or TAB3), leading to the activation of TAK1[Xia et al. 2009].

Literature References

PubMed ID	Title	Journal	Year
14633987	Role of the TAB2-related protein TAB3 in IL-1 and TNF signaling Ishitani, T, Takaesu, G, Ninomiya-Tsuji, J, Shibuya, H, Gaynor, RB, Matsumoto, K	EMBO J	2003
17496917	Ubiquitin-mediated activation of TAK1 and IKK Adhikari, A, Xu, M, Chen, ZJ	Oncogene	2007
15836773	TAK1-binding protein 2 facilitates ubiquitination of TRAF6 and assembly of TRAF6 with IKK in the IL-1 signaling pathway Kishida, S, Sanjo, H, Akira, S, Matsumoto, K, Ninomiya-Tsuji, J	Genes Cells	2005
19675569	Direct activation of protein kinases by unanchored polyubiquitin chains Xia, ZP, Sun, L, Chen, X, Pineda, G, Jiang, X, Adhikari, A, Zeng, W, Chen, ZJ	Nature	2009