Activated TRAF6 synthesizes free K63 linked pUb chains

Stable Identifier
R-GGA-573294
Type
Reaction [omitted]
Species
Gallus gallus
Compartment
cytosol, endosome membrane
ReviewStatus
5/5
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Activated TRAF6 synthesizes free K63 linked pUb chains
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TRAF6 generates unanchored Lys63-linked polyubiquitin chains that bind to the regulatory subunits of the TAK1 (TAB2 or TAB3), leading to the activation of TAK1[Xia et al. 2009].
Literature References
PubMed ID Title Journal Year
17496917 Ubiquitin-mediated activation of TAK1 and IKK

Adhikari, A, Xu, M, Chen, ZJ

Oncogene 2007
19675569 Direct activation of protein kinases by unanchored polyubiquitin chains

Xia, ZP, Sun, L, Chen, X, Pineda, G, Jiang, X, Adhikari, A, Zeng, W, Chen, ZJ

Nature 2009
Participants
Input
Output
Participates
as an event of
Event Information
Go Biological Process
free ubiquitin chain polymerization (0010994)
Catalyst Activity

ubiquitin-ubiquitin ligase activity of oligo pUb-TRAF6 : p-IRAK2 [endosome membrane]

Physical Entity
oligo pUb-TRAF6 : p-IRAK2 [endosome membrane] (Gallus gallus)
Activity
ubiquitin-ubiquitin ligase activity (GO:0034450)
Inferred From
Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation (Homo sapiens)
Authored
Shamovsky, V  (2010-11-30)
Reviewed
D'Eustachio, P  (2010-12-06)
Created
Shamovsky, V  (2010-04-09)
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