Activated human JNKs migrate to nucleoplasm

Stable Identifier
R-HSA-450348
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, nucleoplasm
ReviewStatus
5/5
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Activated human JNKs migrate to nucleoplasm
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c-Jun NH2 terminal kinase (JNK) plays a role in conveying signals from the cytosol to the nucleus, where they associate and activate their target transcription factors.
Literature References
PubMed ID Title Journal Year
12193592 Evidence of functional modulation of the MEKK/JNK/cJun signaling cascade by the low density lipoprotein receptor-related protein (LRP)

Nimpf, J, Lutz, C, Enzinger, C, Baier-Bitterlich, G, Jenny, M, Boecklinger, K, Baier, G, Utermann, G

J Biol Chem 2002
9195981 A novel mechanism of JNK1 activation. Nuclear translocation and activation of JNK1 during ischemia and reperfusion.

Yoshida, K, Morimoto, S, Mizukami, Y, Yoshioka, K

J Biol Chem 1997
13130464 Expression of the MAPK kinases MKK-4 and MKK-7 in rheumatoid arthritis and their role as key regulators of JNK

Boyle, DL, Sundarrajan, M, Chabaud-Riou, M, Firestein, GS, Hammaker, D

Arthritis Rheum 2003
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Orthologous Events
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Activated human JNKs migrate to nucleoplasm (Drosophila melanogaster)
Activated human JNKs migrate to nucleoplasm (Gallus gallus)
Activated human JNKs migrate to nucleoplasm (Mus musculus)
Activated human JNKs migrate to nucleoplasm (Rattus norvegicus)
Activated human JNKs migrate to nucleoplasm (Saccharomyces cerevisiae)
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Activated human JNKs migrate to nucleoplasm (Sus scrofa)
Authored
Shamovsky, V  (2009-12-16)
Reviewed
Gillespie, ME  (2010-02-28)
Created
Shamovsky, V  (2009-12-16)
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