Activated human JNKs migrate to nucleoplasm

Stable Identifier
R-HSA-450348
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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c-Jun NH2 terminal kinase (JNK) plays a role in conveying signals from the cytosol to the nucleus, where they associate and activate their target transcription factors.

Literature References
PubMed ID Title Journal Year
9195981 A novel mechanism of JNK1 activation. Nuclear translocation and activation of JNK1 during ischemia and reperfusion.

Mizukami, Y, Yoshioka, K, Morimoto, S, Yoshida, K

J Biol Chem 1997
12193592 Evidence of functional modulation of the MEKK/JNK/cJun signaling cascade by the low density lipoprotein receptor-related protein (LRP)

Lutz, C, Nimpf, J, Jenny, M, Boecklinger, K, Enzinger, C, Utermann, G, Baier-Bitterlich, G, Baier, G

J Biol Chem 2002
13130464 Expression of the MAPK kinases MKK-4 and MKK-7 in rheumatoid arthritis and their role as key regulators of JNK

Sundarrajan, M, Boyle, DL, Chabaud-Riou, M, Hammaker, D, Firestein, GS

Arthritis Rheum 2003
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