Reactome | Activated human JNKs migrate to nucleoplasm

Activated human JNKs migrate to nucleoplasm

Stable Identifier

R-HSA-450348

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

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Immune System (Homo sapiens)

- Cytokine Signaling in Immune system (Homo sapiens)
  - Signaling by Interleukins (Homo sapiens)
    - Interleukin-17 signaling (Homo sapiens)
      - MAP kinase activation (Homo sapiens)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
        
        Activated human JNKs migrate to nucleoplasm (Homo sapiens)
- Innate Immune System (Homo sapiens)
  - Fc epsilon receptor (FCERI) signaling (Homo sapiens)
    - FCERI mediated MAPK activation (Homo sapiens)
      - Activated human JNKs migrate to nucleoplasm (Homo sapiens)
  - Toll-like Receptor Cascades (Homo sapiens)
    - Toll Like Receptor 10 (TLR10) Cascade (Homo sapiens)
      - MyD88 cascade initiated on plasma membrane (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
        
        Activated human JNKs migrate to nucleoplasm (Homo sapiens)
    - Toll Like Receptor 2 (TLR2) Cascade (Homo sapiens)
      - Toll Like Receptor TLR1:TLR2 Cascade (Homo sapiens)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
        
        Activated human JNKs migrate to nucleoplasm (Homo sapiens)
      - Toll Like Receptor TLR6:TLR2 Cascade (Homo sapiens)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
        
        Activated human JNKs migrate to nucleoplasm (Homo sapiens)
    - Toll Like Receptor 3 (TLR3) Cascade (Homo sapiens)
      - MAP kinase activation (Homo sapiens)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
        
        Activated human JNKs migrate to nucleoplasm (Homo sapiens)
    - Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
      - MyD88-independent TLR4 cascade (Homo sapiens)
        
        TRIF (TICAM1)-mediated TLR4 signaling (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
        
        Activated human JNKs migrate to nucleoplasm (Homo sapiens)
      - MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
        
        Activated human JNKs migrate to nucleoplasm (Homo sapiens)
    - Toll Like Receptor 5 (TLR5) Cascade (Homo sapiens)
      - MyD88 cascade initiated on plasma membrane (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
        
        Activated human JNKs migrate to nucleoplasm (Homo sapiens)
    - Toll Like Receptor 7/8 (TLR7/8) Cascade (Homo sapiens)
      - MyD88 dependent cascade initiated on endosome (Homo sapiens)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
        
        Activated human JNKs migrate to nucleoplasm (Homo sapiens)
    - Toll Like Receptor 9 (TLR9) Cascade (Homo sapiens)
      - MyD88 dependent cascade initiated on endosome (Homo sapiens)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
        
        Activated human JNKs migrate to nucleoplasm (Homo sapiens)

General

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Activated human JNKs migrate to nucleoplasm

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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

c-Jun NH2 terminal kinase (JNK) plays a role in conveying signals from the cytosol to the nucleus, where they associate and activate their target transcription factors.

Literature References

PubMed ID	Title	Journal	Year
12193592	Evidence of functional modulation of the MEKK/JNK/cJun signaling cascade by the low density lipoprotein receptor-related protein (LRP) Lutz, C, Nimpf, J, Jenny, M, Boecklinger, K, Enzinger, C, Utermann, G, Baier-Bitterlich, G, Baier, G	J Biol Chem	2002
9195981	A novel mechanism of JNK1 activation. Nuclear translocation and activation of JNK1 during ischemia and reperfusion. Mizukami, Y, Yoshioka, K, Morimoto, S, Yoshida, K	J Biol Chem	1997
13130464	Expression of the MAPK kinases MKK-4 and MKK-7 in rheumatoid arthritis and their role as key regulators of JNK Sundarrajan, M, Boyle, DL, Chabaud-Riou, M, Hammaker, D, Firestein, GS	Arthritis Rheum	2003