Activated JNK migrates to the nucleoplasm

Stable Identifier
Reaction [transition]
Gallus gallus
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Shortly after phosphorylation JNKs are translocated to nucleus where they associate and activate their target transcription factors.

Literature References
PubMed ID Title Journal Year
9195981 A novel mechanism of JNK1 activation. Nuclear translocation and activation of JNK1 during ischemia and reperfusion.

Mizukami, Y, Yoshioka, K, Morimoto, S, Yoshida, K

J Biol Chem 1997
12193592 Evidence of functional modulation of the MEKK/JNK/cJun signaling cascade by the low density lipoprotein receptor-related protein (LRP)

Lutz, C, Nimpf, J, Jenny, M, Boecklinger, K, Enzinger, C, Utermann, G, Baier-Bitterlich, G, Baier, G

J Biol Chem 2002
13130464 Expression of the MAPK kinases MKK-4 and MKK-7 in rheumatoid arthritis and their role as key regulators of JNK

Sundarrajan, M, Boyle, DL, Chabaud-Riou, M, Hammaker, D, Firestein, GS

Arthritis Rheum 2003
Participant Of
Inferred From
Cite Us!