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IL1B(117-269) [cytosol]
Stable Identifier
R-HSA-449046
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Interleukin-1 beta, IL1B_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Parasitic Infection Pathways (Homo sapiens)
Leishmania infection (Homo sapiens)
Cell recruitment (pro-inflammatory response) (Homo sapiens)
Purinergic signaling in leishmaniasis infection (Homo sapiens)
Interleukin-1 family are secreted (Homo sapiens)
Interleukin-1 family [cytosol] (Homo sapiens)
IL1B(117-269) [cytosol] (Homo sapiens)
Interleukin-1 family precursors are cleaved by caspase-1 (Homo sapiens)
Interleukin-1 family [cytosol] (Homo sapiens)
IL1B(117-269) [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-1 family signaling (Homo sapiens)
Interleukin-1 processing (Homo sapiens)
Interleukin-1 family are secreted (Homo sapiens)
Interleukin-1 family [cytosol] (Homo sapiens)
IL1B(117-269) [cytosol] (Homo sapiens)
Interleukin-1 family precursors are cleaved by caspase-1 (Homo sapiens)
Interleukin-1 family [cytosol] (Homo sapiens)
IL1B(117-269) [cytosol] (Homo sapiens)
Interleukin-1 signaling (Homo sapiens)
p62:MEKK3 binds to TRAF6 (Homo sapiens)
IL1B(117-269) [cytosol] (Homo sapiens)
Innate Immune System (Homo sapiens)
C-type lectin receptors (CLRs) (Homo sapiens)
CLEC7A (Dectin-1) signaling (Homo sapiens)
CLEC7A/inflammasome pathway (Homo sapiens)
Caspase-8 cleaves IL1B precursor (Homo sapiens)
IL1B(117-269) [cytosol] (Homo sapiens)
Programmed Cell Death (Homo sapiens)
Regulated Necrosis (Homo sapiens)
Pyroptosis (Homo sapiens)
Interleukin-1 family are secreted (Homo sapiens)
Interleukin-1 family [cytosol] (Homo sapiens)
IL1B(117-269) [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P01584 IL1B
Gene Names
IL1B, IL1F2
Chain
propeptide:1-116, chain:117-269
Reference Genes
BioGPS Gene:3553 IL1B
COSMIC (genes):IL1B IL1B
CTD Gene:3553 IL1B
dbSNP Gene:3553 IL1B
ENSEMBL:ENSG00000125538 IL1B
ENSEMBL_homo_sapiens_GENE:ENSG00000125538.12 IL1B
HGNC:5992 IL1B
KEGG Gene (Homo sapiens):3553 IL1B
Monarch:3553 IL1B
NCBI Gene:3553 IL1B
OMIM:147720 IL1B
UCSC:P01584 IL1B
Reference Transcript
RefSeq:NM_000576.2 IL1B
Other Identifiers
11719916_at
1520_s_at
16901986
205067_PM_at
205067_at
2571511
2571512
2571514
2571517
2571519
2571520
2571522
2571525
3553
39402_PM_at
39402_at
8054722
A_23_P79518
GE79235
GO:0000278
GO:0001660
GO:0001819
GO:0001934
GO:0002376
GO:0002711
GO:0003012
GO:0005125
GO:0005149
GO:0005178
GO:0005515
GO:0005576
GO:0005615
GO:0005737
GO:0005764
GO:0005773
GO:0005829
GO:0006351
GO:0006355
GO:0006629
GO:0006886
GO:0006913
GO:0006915
GO:0006954
GO:0006955
GO:0007155
GO:0007165
GO:0007254
GO:0007267
GO:0007566
GO:0008284
GO:0008285
GO:0009743
GO:0010573
GO:0010575
GO:0010628
GO:0010718
GO:0010829
GO:0012501
GO:0014805
GO:0019221
GO:0019904
GO:0022414
GO:0023052
GO:0030141
GO:0030154
GO:0030163
GO:0030213
GO:0030335
GO:0030593
GO:0030730
GO:0030949
GO:0031394
GO:0031410
GO:0031622
GO:0031982
GO:0032308
GO:0032496
GO:0032722
GO:0032725
GO:0032729
GO:0032743
GO:0032755
GO:0032757
GO:0033092
GO:0033198
GO:0034116
GO:0034330
GO:0035234
GO:0035505
GO:0036211
GO:0042102
GO:0043122
GO:0043123
GO:0043226
GO:0043406
GO:0043407
GO:0045429
GO:0045766
GO:0045833
GO:0045840
GO:0045893
GO:0045917
GO:0045944
GO:0046330
GO:0046627
GO:0046827
GO:0048018
GO:0048143
GO:0048856
GO:0048870
GO:0050691
GO:0050729
GO:0050767
GO:0050768
GO:0050796
GO:0050805
GO:0050830
GO:0050886
GO:0050900
GO:0050995
GO:0050996
GO:0050999
GO:0051044
GO:0051091
GO:0051092
GO:0051781
GO:0055085
GO:0060252
GO:0060355
GO:0060559
GO:0070164
GO:0070372
GO:0070487
GO:0070498
GO:0070555
GO:0071222
GO:0071260
GO:0071310
GO:0071466
GO:0071639
GO:0097192
GO:0097398
GO:0098542
GO:0098772
GO:0140014
GO:0150078
GO:1900745
GO:1901135
GO:1901224
GO:1902680
GO:1903140
GO:1903597
GO:2000556
GO:2001240
HMNXSV003029537
ILMN_1775501
PH_hs_0007166
TC02002219.hg
X04500_at
g10835144_3p_at
g10835144_3p_s_at
Participates
as an output of
Caspase-8 cleaves IL1B precursor (Homo sapiens)
as a member of
Interleukin-1 family [cytosol] (Homo sapiens)
This entity regulates
Negatively
p62:MEKK3 binds to TRAF6
(Homo sapiens)
Other forms of this molecule
IL1B [extracellular region]
IL1B(1-116) [cytosol]
IL1B(1-269) [cytosol]
Inferred To
Homologues of IL1B(117-269) [cytosol]
(Sus scrofa)
il1fma [cytosol]
(Danio rerio)
Il1b [cytosol]
(Mus musculus)
Il1b [cytosol]
(Rattus norvegicus)
IL1B [cytosol]
(Bos taurus)
IL1B [cytosol]
(Canis familiaris)
IL1B [cytosol]
(Sus scrofa)
il1b [cytosol]
(Xenopus tropicalis)
LOC110255300 [cytosol]
(Sus scrofa)
LOC110258578 [cytosol]
(Sus scrofa)
il-1beta [cytosol]
(Gallus gallus)
Cross References
RefSeq
NP_000567.1
OpenTargets
ENSG00000125538
GeneCards
P01584
HPA
ENSG00000125538-IL1B
ZINC - Substances
IL1B_HUMAN
Ensembl
ENST00000263341
,
ENSP00000263341
,
ENSG00000125538
ZINC target
P01584
PRO
P01584
Pharos - Targets
P01584
ZINC - Predictions - Purchasable
IL1B_HUMAN
HMDB Protein
HMDBP02072
PDB
4GAI
,
7CHZ
,
3POK
,
5R8I
,
1T4Q
,
31BI
,
5R8A
,
3O4O
,
5R8P
,
5R8G
,
1TP0
,
5R88
,
1TWM
,
2I1B
,
1TOO
,
5MVZ
,
1L2H
,
5R8M
,
2NVH
,
5R8E
,
5R8F
,
5R87
,
41BI
,
5R8K
,
8RYS
,
4DEP
,
1ITB
,
5R8C
,
5R85
,
4G6M
,
5I1B
,
21BI
,
5BVP
,
4GAF
,
1TWE
,
9ILB
,
5R8J
,
5R8O
,
7I1B
,
6I1B
,
6Y8M
,
3LTQ
,
7Z4T
,
1HIB
,
2KH2
,
5R8H
,
1IOB
,
7CHY
,
5R89
,
5R8Q
,
5R8D
,
1I1B
,
8C3U
,
4G6J
,
5R8N
,
5R86
,
6Y8I
,
4I1B
,
5R8B
,
5R8L
,
1S0L
,
5R7W
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9NPH3 IL1RAP
0.764
7
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