Caspase-8 cleaves IL1B precursor

Stable Identifier
R-HSA-5660663
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Interleukin-1beta (IL1B) is secreted as inactive precursor, and the processing of pro-IL1B depends on cleavage by proteases. Active caspase-8 inflammasome is capable of cleaving the 31-kDa inactive IL1B precursor form into the bioactive 17-kDa IL1B.

Literature References
PubMed ID Title Journal Year
1574116 A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes

Thornberry, NA, Bull, HG, Calaycay, JR, Chapman, KT, Howard, AD, Kostura, MJ, Miller, DK, Molineaux, SM, Weidner, JR, Aunins, J

Nature 1992
22267217 Dectin-1 is an extracellular pathogen sensor for the induction and processing of IL-1? via a noncanonical caspase-8 inflammasome

Gringhuis, SI, Kaptein, TM, Wevers, BA, Theelen, B, van der Vlist, M, Boekhout, T, Geijtenbeek, TB

Nat. Immunol. 2012
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
cysteine-type endopeptidase activity of MALT1 oligomers:active caspase-8:ASC [cytosol]
Physical Entity
Activity
Orthologous Events
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Reviewed
Created