Reactome | Caspase-8 cleaves IL1B precursor

Caspase-8 cleaves IL1B precursor

Stable Identifier

R-HSA-5660663

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Interleukin-1beta (IL1B) is secreted as inactive precursor, and the processing of pro-IL1B depends on cleavage by proteases. Active caspase-8 inflammasome is capable of cleaving the 31-kDa inactive IL1B precursor form into the bioactive 17-kDa IL1B.

Literature References

PubMed ID	Title	Journal	Year
22267217	Dectin-1 is an extracellular pathogen sensor for the induction and processing of IL-1? via a noncanonical caspase-8 inflammasome Geijtenbeek, TB, Gringhuis, SI, Boekhout, T, Theelen, B, Wevers, BA, van der Vlist, M, Kaptein, TM	Nat. Immunol.	2012
1574116	A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes Chapman, KT, Calaycay, JR, Aunins, J, Weidner, JR, Thornberry, NA, Miller, DK, Molineaux, SM, Kostura, MJ, Bull, HG, Howard, AD	Nature	1992