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Neurofascin interactions
Stable Identifier
R-HSA-447043
Type
Pathway
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
L1CAM interactions (Homo sapiens)
Neurofascin interactions (Homo sapiens)
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Neurofascin is an L1 family immunoglobulin cell adhesion molecule involved in axon subcellular targeting and synapse formation during neural development. There are a range of different isoforms identified in Neurofascin of which two of them are well studied the 186kDa commonly referred to as neuronal form and is present in node of Ranvier neurons and the 155kDa form known as a glial form present in schwann cells.
Neurofascin colocalizes with NrCAM and ankyrinG at the nodes of Ranvier. Neurofascin participates in transheterophilic adhesion with NrCAM and stimulates neurite outgrowth in chicken tectal neurons. The last few amino acids of neurofascin form the PDZ class I binding motif (SLA) and through these last few amino acids it associates with syntenin-1.
Literature References
PubMed ID
Title
Journal
Year
10662501
Structural and functional evolution of the L1 family: are four adhesion molecules better than one?
Hortsch, M
Mol Cell Neurosci
2000
19356150
The intracellular interactions of the L1 family of cell adhesion molecules
Gunn-Moore, FJ
,
Hill, M
,
Herron, LR
,
Davey, F
Biochem J
2009
Participants
Events
Neurofascin binds Ankyrin-G
(Homo sapiens)
Trans-homodimerization of Neurofascin
(Homo sapiens)
Neurofascin and NrCAM heterodimerization
(Homo sapiens)
Phosphorylation of Neurofascin
(Homo sapiens)
Doublecortin binds phosphorylated neurofascin
(Homo sapiens)
Neurofascin interacts with syntenin-1
(Homo sapiens)
Neurofascin binds contactin-1:CASPR complex
(Homo sapiens)
Participates
as an event of
L1CAM interactions (Homo sapiens)
Orthologous Events
Neurofascin interactions (Bos taurus)
Neurofascin interactions (Caenorhabditis elegans)
Neurofascin interactions (Canis familiaris)
Neurofascin interactions (Mus musculus)
Neurofascin interactions (Rattus norvegicus)
Neurofascin interactions (Sus scrofa)
Authored
Garapati, P V (2008-07-30)
Reviewed
Maness, PF (2010-02-16)
Created
Garapati, P V (2009-11-19)
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