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Phosphorylation of Neurofascin
Stable Identifier
R-HSA-445091
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
,
plasma membrane
ReviewStatus
5/5
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Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
L1CAM interactions (Homo sapiens)
Neurofascin interactions (Homo sapiens)
Phosphorylation of Neurofascin (Homo sapiens)
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The highly conserved FIGQY motif in the cytoplasmic domain of neurofascin is phosphorylated by tyrosine kinases in response to external signals. Phosphorylation of the tyrosine in the FIGQY motif inhibits ankyrin binding.
Participants
Input
ATP [cytosol]
Trans neurofascin dimer:ankyrin-G [plasma membrane]
(Homo sapiens)
Output
ADP [cytosol]
ANK1 [cytosol]
(Homo sapiens)
NFASC:pNFASC [plasma membrane]
(Homo sapiens)
Entity On Other Cell
NFASC [plasma membrane]
(Homo sapiens)
Participates
as an event of
Neurofascin interactions (Homo sapiens)
Catalyst Activity
protein tyrosine kinase activity of unidentified protein tyrosine kinase [cytosol]
Physical Entity
unidentified protein tyrosine kinase [cytosol]
(Homo sapiens)
Activity
protein tyrosine kinase activity (GO:0004713)
Inferred From
Phosphorylation of Neurofascin (Rattus norvegicus)
Authored
Garapati, P V (2008-07-30)
Reviewed
Maness, PF (2010-02-16)
Created
Garapati, P V (2009-10-27)
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