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SORBS1 [cytosol]
Stable Identifier
R-HSA-445795
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Sorbin and SH3 domain-containing protein 1, SRBS1_HUMAN
Locations in the PathwayBrowser
Expand all
Muscle contraction (Homo sapiens)
Smooth Muscle Contraction (Homo sapiens)
ATP Hydrolysis By Myosin (Homo sapiens)
ADP:Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
integrin:cytoskeletal adhesion complex [plasma membrane] (Homo sapiens)
SORBS1 [cytosol] (Homo sapiens)
ATP:Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
integrin:cytoskeletal adhesion complex [plasma membrane] (Homo sapiens)
SORBS1 [cytosol] (Homo sapiens)
Calcium Binds Caldesmon (Homo sapiens)
Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
integrin:cytoskeletal adhesion complex [plasma membrane] (Homo sapiens)
SORBS1 [cytosol] (Homo sapiens)
Inactive Myosin Actin Contractile Complex [plasma membrane] (Homo sapiens)
integrin:cytoskeletal adhesion complex [plasma membrane] (Homo sapiens)
SORBS1 [cytosol] (Homo sapiens)
Myosin Binds ATP (Homo sapiens)
ATP:Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
integrin:cytoskeletal adhesion complex [plasma membrane] (Homo sapiens)
SORBS1 [cytosol] (Homo sapiens)
p-S CALD1-Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
integrin:cytoskeletal adhesion complex [plasma membrane] (Homo sapiens)
SORBS1 [cytosol] (Homo sapiens)
Release Of ADP From Myosin (Homo sapiens)
ADP:Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
integrin:cytoskeletal adhesion complex [plasma membrane] (Homo sapiens)
SORBS1 [cytosol] (Homo sapiens)
Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
integrin:cytoskeletal adhesion complex [plasma membrane] (Homo sapiens)
SORBS1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9BX66 SORBS1
Gene Names
SORBS1, KIAA0894, KIAA1296, SH3D5
Chain
chain:1-1292
Reference Genes
BioGPS Gene:10580 SORBS1
COSMIC (genes):SORBS1 SORBS1
CTD Gene:10580 SORBS1
dbSNP Gene:10580 SORBS1
ENSEMBL:ENSG00000095637 SORBS1
HGNC:14565 SORBS1
Monarch:10580 SORBS1
NCBI Gene:10580 SORBS1
OMIM:605264 SORBS1
UCSC:Q9BX66 SORBS1
Reference Transcript
RefSeq:NM_001034957.1 SORBS1
RefSeq:XM_006717589.1 SORBS1
RefSeq:NM_006434.2 SORBS1
RefSeq:NM_001034955.1 SORBS1
RefSeq:NM_001290295.1 SORBS1
RefSeq:NM_001290296.1 SORBS1
RefSeq:NM_001034954.1 SORBS1
RefSeq:NM_015385.3 SORBS1
RefSeq:NM_001290294.1 SORBS1
RefSeq:NM_001290298.1 SORBS1
RefSeq:NM_024991.2 SORBS1
RefSeq:NM_001290297.1 SORBS1
RefSeq:NM_001034956.1 SORBS1
Other Identifiers
10580
11725742_a_at
11725743_s_at
11725744_x_at
11725745_a_at
11746303_a_at
11749118_a_at
11754509_a_at
16716795
211705_PM_s_at
211705_s_at
211819_PM_s_at
211819_s_at
218087_PM_s_at
218087_s_at
222513_PM_s_at
222513_s_at
3301273
3301274
3301275
3301276
3301277
3301278
3301279
3301280
3301281
3301284
3301285
3301286
3301287
3301288
3301300
3301301
3301302
3301303
3301309
3301310
3301311
3301312
3301313
3301316
3301323
3301327
3301330
3301331
3301332
3301333
3301334
3301335
3301339
3301344
3301346
3301348
3301355
3301356
3301357
3301358
3301359
3301360
3301361
3301363
3301364
3301365
3301368
3301382
3301384
3301389
3301390
3301393
3301397
3301399
3301400
3301401
3301402
3301403
3301404
3301406
3301407
3301408
3301411
3301412
3301413
3301417
3301418
3301423
3301432
3301437
3301447
3301449
3301450
3301451
3301478
56409_at
7935188
A_23_P202388
A_24_P317907
A_24_P326511
A_33_P3288329
A_33_P3313314
GE56479
GO:0001725
GO:0003779
GO:0005158
GO:0005515
GO:0005634
GO:0005737
GO:0005813
GO:0005815
GO:0005829
GO:0005856
GO:0005886
GO:0005912
GO:0005915
GO:0005925
GO:0007010
GO:0007155
GO:0007160
GO:0008092
GO:0008286
GO:0016363
GO:0016600
GO:0030055
GO:0030159
GO:0031589
GO:0032869
GO:0034330
GO:0043149
GO:0043226
GO:0045121
GO:0045725
GO:0046326
GO:0046628
GO:0046889
GO:0048041
GO:0060090
GO:0070161
GO:1903078
HMNXSV003022504
Hs.108924.0.S1_3p_a_at
ILMN_1663446
ILMN_1749792
ILMN_2258689
ILMN_2266224
ILMN_2326262
PH_hs_0031870
TC10001550.hg
g6651088_3p_s_at
g7661699_3p_a_at
Participates
as a component of
integrin:cytoskeletal adhesion complex [plasma membrane] (Homo sapiens)
Inferred To
Homologues of SORBS1 [cytosol]
(Caenorhabditis elegans)
CAP [cytosol]
(Drosophila melanogaster)
Ghost homologue of SORBS1 [cytosol]
(Rattus norvegicus)
Sorbs1 [cytosol]
(Mus musculus)
sorb-1 [cytosol]
(Caenorhabditis elegans)
SORBS1 [cytosol]
(Bos taurus)
SORBS1 [cytosol]
(Caenorhabditis elegans)
SORBS1 [cytosol]
(Canis familiaris)
SORBS1 [cytosol]
(Gallus gallus)
SORBS1 [cytosol]
(Sus scrofa)
Cross References
OpenTargets
ENSG00000095637
ENSEMBL
ENST00000361941
,
ENSP00000302556
,
ENST00000306402
,
ENSP00000360283
,
ENSP00000360295
,
ENSP00000360271
,
ENSP00000360293
,
ENST00000371247
,
ENSP00000355136
,
ENST00000277982
,
ENST00000607232
,
ENSP00000360291
,
ENSP00000475901
,
ENST00000371239
,
ENST00000354106
,
ENST00000371227
,
ENST00000371249
,
ENSP00000277982
,
ENSP00000360292
,
ENST00000371246
,
ENST00000371245
,
ENSP00000277984
,
ENSP00000360285
,
ENST00000371241
HPA
ENSG00000095637-SORBS1
PRO
Q9BX66
Pharos - Targets
Q9BX66
GlyGen
Q9BX66
PDB
4LNP
,
4LN2
,
2O9V
,
2DL3
,
2O31
,
2ECZ
,
2O9S
,
2MOX
,
2O2W
,
2LJ0
,
2LJ1
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O15357 INPPL1
1
INPPL1 [cytosol]
(R-HSA-913354)
0.581
5
UniProt:Q13177 PAK2
11
p-S141,T402-PAK2 [cytosol]
(R-HSA-399824)
PAK2 [cytosol]
(R-HSA-211604)
p-5S-PAK2 [cytosol]
(R-HSA-211609)
PAK2(213-524) [cytosol]
(R-HSA-211653)
p-5S-PAK2(2-212) [cytosol]
(R-HSA-211588)
p-T402-PAK2(213-524) [cytosol]
(R-HSA-211654)
p-T402-PAK2(213-524) [nucleoplasm]
(R-HSA-211709)
K48polyUb-p-T402-PAK-2p43 [cytosol]
(R-HSA-3095873)
p-Y130,S141,T402-PAK2 [cytosol]
(R-HSA-5218705)
PAK2(1-524) [plasma membrane]
(R-HSA-164946)
p-S141,T402-PAK2 [plasma membrane]
(R-HSA-5096524)
0.524
2
UniProt:P00519 ABL1
6
p-S456-ABL1 [nucleoplasm]
(R-HSA-5686576)
ABL1 [nucleoplasm]
(R-HSA-5686579)
p-Y226,Y393-ABL1 [cytosol]
(R-HSA-8942610)
ABL1 [cytosol]
(R-HSA-375987)
p-Y226,Y393-ABL1 [nucleoplasm]
(R-HSA-8985251)
p-Y393-ABL1 [cytosol]
(R-HSA-9865161)
0.524
2
UniProt:P39052 Dnm2
5
DNM2 [Golgi membrane]
(R-RNO-2980842)
DNM2 [endocytic vesicle membrane]
(R-RNO-2029000)
Dnm2 [cytosol]
(R-RNO-9619847)
DNM2 [lysosomal membrane]
(R-RNO-2980840)
Dynamin-2 [plasma membrane]
(R-RNO-941852)
0.499
5
UniProt:P31946 YWHAB
1
YWHAB [cytosol]
(R-HSA-48888)
0.483
3
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