Reactome | INPPL1 [cytosol]

INPPL1 [cytosol]

Stable Identifier

R-HSA-913354

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

SHIP2, Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2, SHIP2_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:O15357 INPPL1

Gene Names

INPPL1, SHIP2

Chain

chain:1-1258

Reference Genes

BioGPS Gene:3636 INPPL1

COSMIC (genes):INPPL1 INPPL1

CTD Gene:3636 INPPL1

dbSNP Gene:3636 INPPL1

ENSEMBL:ENSG00000165458.15 INPPL1

HGNC:6080 INPPL1

KEGG Gene (Homo sapiens):3636 INPPL1

Monarch:3636 INPPL1

NCBI Gene:3636 INPPL1

OMIM:600829 INPPL1

UCSC:O15357 INPPL1

Reference Transcript

Other Identifiers

0004810142

11720733_a_at

11720734_s_at

11754199_a_at

16728652

201598_PM_s_at

201598_s_at

3339429

3339430

3339431

3339434

3339435

3339436

3339437

3339439

3339440

3339441

3339442

3339443

3339444

3339445

3339447

3339448

3339450

3339452

3339453

3339455

3339456

3339457

3339459

3339461

3339462

3339463

3339464

3339465

3339466

3339468

3339470

3339471

3339472

3339473

3339474

3339476

3339477

3339479

3339480

3339481

3636

36598_s_at

7942342

80433_s_at

A_14_P132198

A_14_P132605

A_23_P36322

A_33_P3358253

GE60315

GO:0000132

GO:0000278

GO:0000922

GO:0001958

GO:0002376

GO:0003779

GO:0003824

GO:0004445

GO:0005515

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005794

GO:0005829

GO:0005856

GO:0005886

GO:0005975

GO:0006006

GO:0006629

GO:0006661

GO:0006897

GO:0007010

GO:0007015

GO:0007155

GO:0007163

GO:0008092

GO:0008285

GO:0009791

GO:0009925

GO:0009966

GO:0010629

GO:0016020

GO:0016192

GO:0016607

GO:0016787

GO:0016791

GO:0017124

GO:0019637

GO:0023052

GO:0030027

GO:0030175

GO:0032868

GO:0032880

GO:0034485

GO:0042169

GO:0042995

GO:0043226

GO:0043569

GO:0044255

GO:0046856

GO:0048856

GO:0050776

GO:0097178

GO:0110053

HMNXSV003015451

ILMN_1728426

L36818_at

PH_hs_0004314

TC11000756.hg

g4755141_3p_a_at

Participates

as a component of

CSF1 dimer,IL34 dimer:PolyUb,p-8Y-CSF1R dimer:p-Y-CBL:GRB2:SOS1:p-Y-GAB2:p-Y-GAB3:GRAP2:INPP5D:INPPL1:PI3K:PTPN11:p-Y-SHC1:p-Y-PLCG2 [plasma membrane] (Homo sapiens)

as an input of

PIK3R1:PIK3CA,B,G (PI3K), PLCG2 (PLCgamma2), SHC1 (SHC), PTPN11 (SHP2), GRB2:GAB2, GRB2:GAB3, GRAP2 (MONA), CBL:GRB2, INPP5D (SHIP1), INPPL1 (SHIP2) bind PolyUb,p-8Y-CSF1R and are activated (Homo sapiens)

as a member of

Inferred To

INPPL1 [cytosol] (Bos taurus)

INPPL1 [cytosol] (Canis familiaris)

INPPL1 [cytosol] (Gallus gallus)

INPPL1 [cytosol] (Sus scrofa)

inppl1 [cytosol] (Xenopus tropicalis)

inppl1a [cytosol] (Danio rerio)

Inppl1 [cytosol] (Mus musculus)

Inppl1 [cytosol] (Rattus norvegicus)

Cross References

RefSeq

XP_011543301.1, NP_001558.3

Guide to Pharmacology - Targets

1459

OpenTargets

ENSG00000165458

GeneCards

O15357

HPA

ENSG00000165458-INPPL1

Ensembl

ENST00000538751, ENSG00000165458, ENST00000298229, ENSP00000298229, ENSP00000444619

ZINC target

O15357

PRO

O15357

Pharos - Targets

O15357

Orphanet

21752

HMDB Protein

HMDBP03264

PDB

2K4P, 2MK2, 3NR8, 6SQU, 4A9C, 5OKN, 5OKM, 2KSO, 6SRR, 5OKP, 5OKO

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q15811-2 ITSN1			0.602	9
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.597	4
UniProt:P46108 CRK	1	CRK [cytosol] (R-HSA-2980677)	0.59	2
UniProt:Q9BX66 SORBS1	1	SORBS1 [cytosol] (R-HSA-445795)	0.581	5
UniProt:O60504-1 SORBS3			0.508	2
UniProt:Q9QYY0 Gab1	5	phospho-Gab1 [cytosol] (R-MMU-8855306) Gab1 [cytosol] (R-MMU-9031464) phospho-Gab1 [cytosol] (R-MMU-180496) phospho-Gab1 [cytosol] (R-MMU-180344) Gab1 [cytosol] (R-MMU-179795)	0.508	5
UniProt:Q8IV36 HID1			0.508	2
UniProt:A9UF07 A9UF07			0.462	4