Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
INPPL1 [cytosol]
Stable Identifier
R-HSA-913354
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
SHIP2, Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2, SHIP2_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-2 family signaling (Homo sapiens)
Interleukin receptor SHC signaling (Homo sapiens)
Phosphorylated SHC1 recruits SHIP (Homo sapiens)
Interleukin receptor complexes with activated SHC1:SHIP1,2 [plasma membrane] (Homo sapiens)
SHIP1,2 [cytosol] (Homo sapiens)
INPPL1 [cytosol] (Homo sapiens)
SHIP1,2 [cytosol] (Homo sapiens)
INPPL1 [cytosol] (Homo sapiens)
Interleukin-3, Interleukin-5 and GM-CSF signaling (Homo sapiens)
Interleukin receptor SHC signaling (Homo sapiens)
Phosphorylated SHC1 recruits SHIP (Homo sapiens)
Interleukin receptor complexes with activated SHC1:SHIP1,2 [plasma membrane] (Homo sapiens)
SHIP1,2 [cytosol] (Homo sapiens)
INPPL1 [cytosol] (Homo sapiens)
SHIP1,2 [cytosol] (Homo sapiens)
INPPL1 [cytosol] (Homo sapiens)
Metabolism (Homo sapiens)
Inositol phosphate metabolism (Homo sapiens)
Synthesis of IP3 and IP4 in the cytosol (Homo sapiens)
I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol (Homo sapiens)
INPP5(3)/ITPK1 [cytosol] (Homo sapiens)
INPPL1 [cytosol] (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Phospholipid metabolism (Homo sapiens)
PI Metabolism (Homo sapiens)
Synthesis of PIPs at the plasma membrane (Homo sapiens)
PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Homo sapiens)
INPP5(2) [cytosol] (Homo sapiens)
INPPL1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:O15357 INPPL1
Gene Names
INPPL1, SHIP2
Chain
chain:1-1258
Reference Genes
BioGPS Gene:3636 INPPL1
COSMIC (genes):INPPL1 INPPL1
CTD Gene:3636 INPPL1
dbSNP Gene:3636 INPPL1
ENSEMBL:ENSG00000165458 INPPL1
HGNC:6080 INPPL1
KEGG Gene (Homo sapiens):3636 INPPL1
Monarch:3636 INPPL1
NCBI Gene:3636 INPPL1
OMIM:600829 INPPL1
UCSC:O15357 INPPL1
Reference Transcript
RefSeq:NM_001567.3 INPPL1
RefSeq:XM_011544999.2 INPPL1
Other Identifiers
0004810142
11720733_a_at
11720734_s_at
11754199_a_at
16728652
201598_s_at
3339429
3339430
3339431
3339434
3339435
3339436
3339437
3339439
3339440
3339441
3339442
3339443
3339444
3339445
3339447
3339448
3339450
3339452
3339453
3339455
3339456
3339457
3339459
3339461
3339462
3339463
3339464
3339465
3339466
3339468
3339470
3339471
3339472
3339473
3339474
3339476
3339477
3339479
3339480
3339481
3636
36598_s_at
7942342
80433_s_at
A_14_P132198
A_14_P132605
A_23_P36322
A_33_P3358253
GE60315
GO:0001958
GO:0002376
GO:0003674
GO:0003779
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005737
GO:0005794
GO:0005829
GO:0005856
GO:0005886
GO:0005975
GO:0006006
GO:0006629
GO:0006661
GO:0006810
GO:0006897
GO:0007010
GO:0007015
GO:0007155
GO:0007165
GO:0008092
GO:0008150
GO:0008283
GO:0008285
GO:0009058
GO:0009791
GO:0010629
GO:0016020
GO:0016192
GO:0016607
GO:0016787
GO:0017124
GO:0019221
GO:0022607
GO:0030027
GO:0030175
GO:0032868
GO:0042169
GO:0042995
GO:0043226
GO:0043647
GO:0044255
GO:0044281
GO:0046856
GO:0048856
GO:0097178
ILMN_1728426
L36818_at
PH_hs_0004314
TC11000756.hg
g4755141_3p_a_at
Participant Of
hasMember
INPP5(2) [cytosol]
INPP5(3)/ITPK1 [cytosol]
SHIP1,2 [cytosol]
Inferred To
INPPL1 [cytosol] (Bos taurus)
INPPL1 [cytosol] (Canis familiaris)
INPPL1 [cytosol] (Gallus gallus)
INPPL1 [cytosol] (Sus scrofa)
INPPL1 [cytosol] (Xenopus tropicalis)
inppl1a [cytosol] (Danio rerio)
Inppl1 [cytosol] (Mus musculus)
Inppl1 [cytosol] (Rattus norvegicus)
Cross References
RefSeq
NP_001558.3
,
XP_011543301.1
OpenTargets
ENSG00000165458
HPA
ENSG00000165458-INPPL1
GeneCards
O15357
ZINC target
O15357
Ensembl
ENSG00000165458
,
ENSP00000298229
,
ENST00000538751
,
ENST00000298229
,
ENSP00000444619
PRO
O15357
Orphanet
21752
HMDB Protein
HMDBP03264
PDB
5OKN
,
2MK2
,
5OKP
,
4A9C
,
2K4P
,
2KSO
,
3NR8
,
5OKO
,
5OKM
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P62993 GRB2
1
GRB2 [cytosol]
(R-HSA-8983328)
0.597
4
UniProt:Q9QYY0 Gab1
5
Gab1 [cytosol]
(R-MMU-9031464)
phospho-Gab1 [cytosol]
(R-MMU-8855306)
phospho-Gab1 [cytosol]
(R-MMU-180496)
phospho-Gab1 [cytosol]
(R-MMU-180344)
Gab1 [cytosol]
(R-MMU-179795)
0.508
5
© 2021
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text