Reactome | G-protein coupled bile acid receptor binds lithocholic acid

G-protein coupled bile acid receptor binds lithocholic acid

Stable Identifier

R-HSA-444654

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

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G-protein coupled bile acid receptor binds lithocholic acid

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The G-protein coupled bile acid receptor (GPBAR1) responds to several bile acids the most potent being lithocholic acid. Primary bile acids are acidic sterols synthesized from cholesterol in the liver where they are conjugated with glycine or taurine. Following synthesis bile acids are stored in the gall bladder and secreted into the duodenum where they facilitate solubilization and absorption of lipid-soluble vitamins and dietary fats. Bile acids can also regulate expression of various transport proteins and enzymes through the binding and activation of nuclear receptors, particularly FXR.

Literature References

PubMed ID	Title	Journal	Year
12524422	A G protein-coupled receptor responsive to bile acids Kawamata, Y, Fujii, R, Hosoya, M, Harada, M, Yoshida, H, Miwa, M, Fukusumi, S, Habata, Y, Itoh, T, Shintani, Y, Hinuma, S, Fujisawa, Y, Fujino, M	J Biol Chem	2003