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GPBAR1 [plasma membrane]
Stable Identifier
R-HSA-444640
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
G-protein coupled bile acid receptor 1, GPBAR_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (s) signalling events (Homo sapiens)
Liganded Gs-activating GPCR acts as a GEF for Gs (Homo sapiens)
GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
GPBAR1: Bile acids [plasma membrane] (Homo sapiens)
GPBAR1 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
GPBAR1: Bile acids [plasma membrane] (Homo sapiens)
GPBAR1 [plasma membrane] (Homo sapiens)
Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
GPBAR1: Bile acids [plasma membrane] (Homo sapiens)
GPBAR1 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
GPBAR1: Bile acids [plasma membrane] (Homo sapiens)
GPBAR1 [plasma membrane] (Homo sapiens)
The Ligand:GPCR:Gs complex dissociates (Homo sapiens)
GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
GPBAR1: Bile acids [plasma membrane] (Homo sapiens)
GPBAR1 [plasma membrane] (Homo sapiens)
GPCRs that activate Gs [plasma membrane] (Homo sapiens)
GPBAR1 [plasma membrane] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
G-protein coupled bile acid receptor binds lithocholic acid (Homo sapiens)
GPBAR1 [plasma membrane] (Homo sapiens)
GPBAR1: Bile acids [plasma membrane] (Homo sapiens)
GPBAR1 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8TDU6 GPBAR1
Gene Names
GPBAR1, TGR5
Chain
chain:1-330
Reference Genes
BioGPS Gene:151306 GPBAR1
COSMIC (genes):GPBAR1 GPBAR1
CTD Gene:151306 GPBAR1
dbSNP Gene:151306 GPBAR1
ENSEMBL:ENSG00000179921 GPBAR1
ENSEMBL_homo_sapiens_GENE:ENSG00000179921.15 GPBAR1
HGNC:19680 GPBAR1
KEGG Gene (Homo sapiens):151306 GPBAR1
Monarch:151306 GPBAR1
NCBI Gene:151306 GPBAR1
OMIM:610147 GPBAR1
UCSC:Q8TDU6 GPBAR1
Reference Transcript
RefSeq:NM_001321950.1 GPBAR1
RefSeq:NM_170699.2 GPBAR1
RefSeq:XM_011510743.1 GPBAR1
RefSeq:XM_017003467.1 GPBAR1
RefSeq:NM_001077191.1 GPBAR1
RefSeq:XM_017003468.1 GPBAR1
RefSeq:NM_001077194.1 GPBAR1
RefSeq:XM_017003469.1 GPBAR1
Other Identifiers
11737507_a_at
151306
1552501_PM_a_at
1552501_a_at
16890787
2527654
2527656
2527657
2527658
2527659
2527660
2527661
2527662
2527664
2527665
2527666
8048249
81914_at
A_23_P400378
GE87895
GO:0004930
GO:0005737
GO:0005886
GO:0007165
GO:0007186
GO:0016020
GO:0023052
GO:0034330
GO:0038181
GO:0038182
GO:0038184
GO:0043235
GO:0060089
GO:0070374
GO:1903413
GO:1904056
GO:2000810
HMNXSV003017584
Hs2.160954.1.S1_3p_s_at
ILMN_1727709
ILMN_1826580
ILMN_2316386
PH_hs_0009780
TC02001296.hg
Participates
as an input of
G-protein coupled bile acid receptor binds lithocholic acid (Homo sapiens)
as a member of
GPCRs that activate Gs [plasma membrane] (Homo sapiens)
as a component of
GPBAR1: Bile acids [plasma membrane] (Homo sapiens)
Inferred To
gtr-1 [plasma membrane]
(Caenorhabditis elegans)
gpbar1 [plasma membrane]
(Xenopus tropicalis)
Gpbar1 [plasma membrane]
(Mus musculus)
Gpbar1 [plasma membrane]
(Rattus norvegicus)
Homologues of GPBAR1 [plasma membrane]
(Caenorhabditis elegans)
AdoR [plasma membrane]
(Drosophila melanogaster)
GPBAR1 [plasma membrane]
(Bos taurus)
GPBAR1 [plasma membrane]
(Caenorhabditis elegans)
GPBAR1 [plasma membrane]
(Canis familiaris)
GPBAR1 [plasma membrane]
(Sus scrofa)
ador-1 [plasma membrane]
(Caenorhabditis elegans)
Cross References
RefSeq
NP_733800.1
,
XP_016858956.1
,
NP_001070662.1
,
XP_016858957.1
,
XP_016858958.1
,
XP_011509045.1
,
NP_001308879.1
,
NP_001070659.1
ZINC - World Drugs
GPBAR_HUMAN
Guide to Pharmacology - Targets
37
OpenTargets
ENSG00000179921
ZINC - FDA approved
GPBAR_HUMAN
ZINC - Substances
GPBAR_HUMAN
ZINC target
Q8TDU6
ZINC - Biogenic
GPBAR_HUMAN
PRO
Q8TDU6
PDB
7BW0
,
7CFM
,
7XTQ
,
7CFN
ZINC - Investigational
GPBAR_HUMAN
ZINC - Metabolites
GPBAR_HUMAN
GeneCards
Q8TDU6
HPA
ENSG00000179921-GPBAR1
Ensembl
ENST00000521462
,
ENSP00000428824
,
ENST00000519574
,
ENST00000522678
,
ENSG00000179921
,
ENSP00000430698
,
ENST00000479077
,
ENSP00000430886
,
ENSP00000430202
Pharos - Targets
Q8TDU6
ZINC - Predictions - Purchasable
GPBAR_HUMAN
Orphanet
24568
HMDB Protein
HMDBP08128
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P38646 HSP9
6
HSPA9 [nucleoplasm]
(R-HSA-5252128)
HSPA9 [cytosol]
(R-HSA-5251993)
HSPA9 [mitochondrial matrix]
(R-HSA-8878802)
HSPA9(1-679) [mitochondrial intermembrane space]
(R-HSA-1267968)
HSPA9 [mitochondrial inner membrane]
(R-HSA-1252206)
HSPA9(1-679) [cytosol]
(R-HSA-1267964)
0.463
3
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