Reactome | GPBAR1 [plasma membrane]

GPBAR1 [plasma membrane]

Stable Identifier

R-HSA-444640

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

G-protein coupled bile acid receptor 1, GPBAR_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q8TDU6 GPBAR1

Gene Names

GPBAR1, TGR5

Chain

chain:1-330

Reference Genes

BioGPS Gene:151306 GPBAR1

COSMIC (genes):GPBAR1 GPBAR1

CTD Gene:151306 GPBAR1

dbSNP Gene:151306 GPBAR1

ENSEMBL:ENSG00000179921 GPBAR1

HGNC:19680 GPBAR1

KEGG:hsa:151306 GPBAR1

Monarch:151306 GPBAR1

NCBI Gene:151306 GPBAR1

OMIM:610147 GPBAR1

UCSC:Q8TDU6 GPBAR1

Reference Transcript

Other Identifiers

11737507_a_at

151306

1552501_PM_a_at

1552501_a_at

16890787

2527654

2527656

2527657

2527658

2527659

2527660

2527661

2527662

2527664

2527665

2527666

8048249

81914_at

A_23_P400378

GE87895

GO:0004930

GO:0005515

GO:0005737

GO:0005886

GO:0007186

GO:0016020

GO:0038182

GO:0038184

GO:0043235

GO:0060089

GO:0070374

GO:1903413

GO:1904056

GO:2000810

HMNXSV003017584

Hs2.160954.1.S1_3p_s_at

ILMN_1727709

ILMN_1826580

ILMN_2316386

PH_hs_0009780

TC02001296.hg

Participates

as an input of

G-protein coupled bile acid receptor binds lithocholic acid (Homo sapiens)

as a member of

GPCRs that activate Gs [plasma membrane] (Homo sapiens)

as a component of

GPBAR1: Bile acids [plasma membrane] (Homo sapiens)

Inferred To

gtr-1 [plasma membrane] (Caenorhabditis elegans)

gpbar1 [plasma membrane] (Xenopus tropicalis)

Gpbar1 [plasma membrane] (Mus musculus)

Gpbar1 [plasma membrane] (Rattus norvegicus)

Homologues of GPBAR1 [plasma membrane] (Caenorhabditis elegans)

AdoR [plasma membrane] (Drosophila melanogaster)

GPBAR1 [plasma membrane] (Bos taurus)

GPBAR1 [plasma membrane] (Caenorhabditis elegans)

GPBAR1 [plasma membrane] (Canis familiaris)

GPBAR1 [plasma membrane] (Sus scrofa)

ador-1 [plasma membrane] (Caenorhabditis elegans)

Cross References

RefSeq

XP_016858958.1, NP_001070659.1, NP_001308879.1, XP_016858956.1, XP_011509045.1, XP_016858957.1, NP_733800.1, NP_001070662.1

Guide to Pharmacology - Targets

OpenTargets

ENSG00000179921

ENSEMBL

ENSP00000430886, ENSP00000430202, ENST00000519574, ENSP00000428824, ENSG00000179921, ENSP00000430698, ENST00000521462, ENST00000479077, ENST00000522678

ZINC - FDA approved

GPBAR_HUMAN

ZINC - Substances

GPBAR_HUMAN

ZINC - Biogenic

GPBAR_HUMAN

ZINC target

Q8TDU6

PRO

Q8TDU6

GlyGen

Q8TDU6

PDB

7CFN, 7BW0, 9GYO, 7CFM, 7XTQ

ZINC - Investigational

GPBAR_HUMAN

ZINC - Metabolites

GPBAR_HUMAN

HPA

ENSG00000179921-GPBAR1

GeneCards

GPBAR1

Pharos - Targets

Q8TDU6

ZINC - Predictions - Purchasable

GPBAR_HUMAN

HMDB Protein

HMDBP08128

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P38646 HSPA9	6	HSPA9 [mitochondrial matrix] (R-HSA-8878802) HSPA9 [mitochondrial inner membrane] (R-HSA-1252206) HSPA9(1-679) [cytosol] (R-HSA-1267964) HSPA9(1-679) [mitochondrial intermembrane space] (R-HSA-1267968) HSPA9 [nucleoplasm] (R-HSA-5252128) HSPA9 [cytosol] (R-HSA-5251993)	0.463	3