RhBG mediates ammonium effflux out of kidney collecting duct cells

Stable Identifier
Reaction [transition]
Homo sapiens
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The human gene RhBG encodes a Rhesus blood group family type B glycoprotein which is expressed mainly in the kidney but is also found in the liver. The liver and kidney are important tissues for ammonium metabolism and excretion. RhBG is located on the basolateral membrane and mediates the reversible transport of ammonium in and out of renal collecting duct cells in an electroneutral manner, with H+ transported the other way (Ludewig U, 2004; Liu Z et al, 2001).

Literature References
PubMed ID Title Journal Year
11024028 Rh type B glycoprotein is a new member of the Rh superfamily and a putative ammonia transporter in mammals

Mo, R, Liu, Z, Hui, C, Peng, J, Huang, CH

J Biol Chem 2001
15284342 Electroneutral ammonium transport by basolateral rhesus B glycoprotein

Ludewig, U

J Physiol 2004
Event Information
Catalyst Activity

ammonium transmembrane transporter activity of RHBG [plasma membrane]

Orthologous Events
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