Reactome | RhBG mediates ammonium influx into kidney collecting duct cells

RhBG mediates ammonium influx into kidney collecting duct cells

Stable Identifier

R-HSA-446278

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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RhBG mediates ammonium influx into kidney collecting duct cells

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The human gene RhBG encodes a Rhesus blood group family type B glycoprotein which is expressed mainly in the kidney but is also found in the liver (Liu Z et al, 2001). The liver and kidney are important tissues for ammonium metabolism and excretion (Liu Z et al, 2001). RhBG is located on the basolateral membrane of cells in renal collecting ducts (Ludewig U, 2004; Liu Z et al, 2001). Functional studies of human RhBG expressed in Xenopus oocytes indicate it mediates transport of the ammonium analogue methylammonium in an electroneutral manner, consistent with an NH4+/H+ exchange mechanism (Ludewig U, 2004).

Literature References

PubMed ID	Title	Journal	Year
11024028	Rh type B glycoprotein is a new member of the Rh superfamily and a putative ammonia transporter in mammals Liu, Z, Peng, J, Mo, R, Hui, C, Huang, CH	J Biol Chem	2001
15284342	Electroneutral ammonium transport by basolateral rhesus B glycoprotein Ludewig, U	J Physiol	2004