Reuptake of GABA

Stable Identifier
R-HSA-888593
Type
Pathway
Species
Homo sapiens
Compartment
extracellular region, plasma membrane, cytosol
ReviewStatus
5/5
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 | PPTX  | SBGN
Reuptake of GABA
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Reuptake of GABA from the synapse terminates the action of GABA thus regulating GABA action. GABA taken up from the synapse into the neurons is reused for synaptic loading. GABA taken up by astrocytes is degraded into C02 and glutamine. Glutamine is transported into the neurons for glutamate and GABA synthesis.
Literature References
PubMed ID Title Journal Year
19924586 Effects of the GABA-reuptake inhibitor tiagabine on panic and anxiety in patients with panic disorder

Baghai, TC, Rupprecht, R, Padberg, F, Möller, HJ, Nothdurfter, C, Eser, D, Zwanzger, P

Pharmacopsychiatry 2009
Participants
Events
Participates
as an event of
Event Information
Go Biological Process
gamma-aminobutyric acid reuptake (0051936)
Orthologous Events
Reuptake of GABA (Bos taurus)
Reuptake of GABA (Caenorhabditis elegans)
Reuptake of GABA (Canis familiaris)
Reuptake of GABA (Danio rerio)
Reuptake of GABA (Drosophila melanogaster)
Reuptake of GABA (Gallus gallus)
Reuptake of GABA (Mus musculus)
Reuptake of GABA (Plasmodium falciparum)
Reuptake of GABA (Rattus norvegicus)
Reuptake of GABA (Sus scrofa)
Reuptake of GABA (Xenopus tropicalis)
Cross References
BioModels Database
Authored
Mahajan, SS  (2010-08-02)
Reviewed
Restituito, S  (2008-11-27)
Created
Mahajan, SS  (2010-06-30)
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