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FZD3 [plasma membrane]
Stable Identifier
R-HSA-443948
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Frizzled-3, FZD3_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class B/2 (Secretin family receptors) (Homo sapiens)
Frizzled receptors bind Wnts (Homo sapiens)
Frizzled receptors [plasma membrane] (Homo sapiens)
FZD3 [plasma membrane] (Homo sapiens)
Frizzled receptors:WNTs [plasma membrane] (Homo sapiens)
Frizzled receptors [plasma membrane] (Homo sapiens)
FZD3 [plasma membrane] (Homo sapiens)
Signaling by WNT (Homo sapiens)
Beta-catenin independent WNT signaling (Homo sapiens)
Ca2+ pathway (Homo sapiens)
FZD recruits trimeric G-proteins (Homo sapiens)
WNT5A/11:FZD [plasma membrane] (Homo sapiens)
WNT/Ca2+ FZDs [plasma membrane] (Homo sapiens)
FZD3 [plasma membrane] (Homo sapiens)
WNT5A/11:FZD:G-protein (alpha o/t2) inactive [plasma membrane] (Homo sapiens)
WNT5A/11:FZD [plasma membrane] (Homo sapiens)
WNT/Ca2+ FZDs [plasma membrane] (Homo sapiens)
FZD3 [plasma membrane] (Homo sapiens)
G-protein subunits dissociate from WNT:FZD complex (Homo sapiens)
WNT5A/11:FZD [plasma membrane] (Homo sapiens)
WNT/Ca2+ FZDs [plasma membrane] (Homo sapiens)
FZD3 [plasma membrane] (Homo sapiens)
WNT5A/11:FZD:G-protein (alpha o/t2) active [plasma membrane] (Homo sapiens)
WNT5A/11:FZD [plasma membrane] (Homo sapiens)
WNT/Ca2+ FZDs [plasma membrane] (Homo sapiens)
FZD3 [plasma membrane] (Homo sapiens)
WNT5A and WNT11 bind FZD receptors to initiate Ca2+ signaling (Homo sapiens)
WNT/Ca2+ FZDs [plasma membrane] (Homo sapiens)
FZD3 [plasma membrane] (Homo sapiens)
WNT5A/11:FZD [plasma membrane] (Homo sapiens)
WNT/Ca2+ FZDs [plasma membrane] (Homo sapiens)
FZD3 [plasma membrane] (Homo sapiens)
WNT:FZD complex promotes G-protein nucleotide exchange (Homo sapiens)
WNT5A/11:FZD:G-protein (alpha o/t2) active [plasma membrane] (Homo sapiens)
WNT5A/11:FZD [plasma membrane] (Homo sapiens)
WNT/Ca2+ FZDs [plasma membrane] (Homo sapiens)
FZD3 [plasma membrane] (Homo sapiens)
WNT5A/11:FZD:G-protein (alpha o/t2) inactive [plasma membrane] (Homo sapiens)
WNT5A/11:FZD [plasma membrane] (Homo sapiens)
WNT/Ca2+ FZDs [plasma membrane] (Homo sapiens)
FZD3 [plasma membrane] (Homo sapiens)
PCP/CE pathway (Homo sapiens)
Asymmetric localization of PCP proteins (Homo sapiens)
DVL2 is phosphorylated after WNT5A binding to FZD (Homo sapiens)
WNT5A:FZD [plasma membrane] (Homo sapiens)
WNT5A-binding FZDs [plasma membrane] (Homo sapiens)
FZD3 [plasma membrane] (Homo sapiens)
VANGL2 is required for asymmetric membrane localization of FZD3 (Homo sapiens)
FZD3 [plasma membrane] (Homo sapiens)
VANGL2:SCRIB:FZD3 [plasma membrane] (Homo sapiens)
FZD3 [plasma membrane] (Homo sapiens)
WNT5A binding to FZD promotes PRICKLE1 degradation (Homo sapiens)
WNT5A-binding FZDs [plasma membrane] (Homo sapiens)
FZD3 [plasma membrane] (Homo sapiens)
WNT5A:FZD [plasma membrane] (Homo sapiens)
WNT5A-binding FZDs [plasma membrane] (Homo sapiens)
FZD3 [plasma membrane] (Homo sapiens)
DVL is recruited to the receptor (Homo sapiens)
WNT:FZD [plasma membrane] (Homo sapiens)
PCP pathway FZDs [plasma membrane] (Homo sapiens)
FZD3 [plasma membrane] (Homo sapiens)
WNT:FZD:pDVL [plasma membrane] (Homo sapiens)
WNT:FZD [plasma membrane] (Homo sapiens)
PCP pathway FZDs [plasma membrane] (Homo sapiens)
FZD3 [plasma membrane] (Homo sapiens)
WNT-dependent phosphorylation of DVL (Homo sapiens)
WNT:FZD [plasma membrane] (Homo sapiens)
PCP pathway FZDs [plasma membrane] (Homo sapiens)
FZD3 [plasma membrane] (Homo sapiens)
WNT:FZD:pDVL [plasma membrane] (Homo sapiens)
WNT:FZD [plasma membrane] (Homo sapiens)
PCP pathway FZDs [plasma membrane] (Homo sapiens)
FZD3 [plasma membrane] (Homo sapiens)
WNTs bind the FZD receptor to initiate PCP pathway (Homo sapiens)
PCP pathway FZDs [plasma membrane] (Homo sapiens)
FZD3 [plasma membrane] (Homo sapiens)
WNT:FZD [plasma membrane] (Homo sapiens)
PCP pathway FZDs [plasma membrane] (Homo sapiens)
FZD3 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9NPG1 FZD3
Gene Names
FZD3
Chain
signal peptide:1-22, chain:23-666
Reference Genes
BioGPS Gene:7976 FZD3
COSMIC (genes):FZD3 FZD3
CTD Gene:7976 FZD3
dbSNP Gene:7976 FZD3
ENSEMBL:ENSG00000104290 FZD3
ENSEMBL_homo_sapiens_GENE:ENSG00000104290.11 FZD3
HGNC:4041 FZD3
KEGG Gene (Homo sapiens):7976 FZD3
Monarch:7976 FZD3
NCBI Gene:7976 FZD3
OMIM:606143 FZD3
UCSC:Q9NPG1 FZD3
Reference Transcript
RefSeq:NM_145866.1 FZD3
RefSeq:NM_017412.3 FZD3
Other Identifiers
11732561_a_at
11732562_x_at
11746437_a_at
17067410
219683_PM_at
219683_at
227499_PM_at
227499_at
227524_PM_at
227524_at
239082_PM_at
239082_at
3091747
3091752
3091753
3091754
3091755
3091757
3091760
3091761
3091762
3091763
3091764
3091765
3091766
3091771
3091772
3091774
3091775
3091776
3091777
3091779
3091781
3091783
3091785
3091786
3091788
3091789
3091791
3091792
3091794
50994_at
55592_at
60971_at
60972_g_at
7976
8145611
86904_at
A_14_P117240
A_14_P122274
A_23_P347468
A_32_P211708
GE58747
GE656770
GE869661
GO:0000278
GO:0001736
GO:0001843
GO:0001942
GO:0002052
GO:0004888
GO:0004930
GO:0005515
GO:0005737
GO:0005886
GO:0007165
GO:0007166
GO:0007186
GO:0007399
GO:0009410
GO:0009986
GO:0012501
GO:0016020
GO:0016055
GO:0016324
GO:0016328
GO:0017147
GO:0023052
GO:0030154
GO:0030165
GO:0030182
GO:0030424
GO:0030425
GO:0030901
GO:0032433
GO:0033278
GO:0035567
GO:0036342
GO:0036514
GO:0036515
GO:0042472
GO:0042813
GO:0043025
GO:0045177
GO:0045976
GO:0048786
GO:0048856
GO:0048870
GO:0051602
GO:0060070
GO:0060071
GO:0060089
GO:0061549
GO:0071679
GO:0097475
GO:1900118
GO:1904693
HMNXSV003017716
Hs.208261.0.A1_3p_at
Hs.9012.0.A1_3p_at
Hs.9012.0.A2_3p_at
ILMN_1703408
PH_hs_0003050
TC08000220.hg
TC08001853.hg
g8393377_3p_at
Participates
as a candidate of
Frizzled receptors [plasma membrane] (Homo sapiens)
WNT5A-binding FZDs [plasma membrane] (Homo sapiens)
PCP pathway FZDs [plasma membrane] (Homo sapiens)
as a component of
VANGL2:SCRIB:FZD3 [plasma membrane] (Homo sapiens)
as an input of
VANGL2 is required for asymmetric membrane localization of FZD3 (Homo sapiens)
as a member of
WNT/Ca2+ FZDs [plasma membrane] (Homo sapiens)
Inferred To
fzd3b [plasma membrane]
(Danio rerio)
Fzd3 [plasma membrane]
(Mus musculus)
Fzd3 [plasma membrane]
(Rattus norvegicus)
fz [plasma membrane]
(Drosophila melanogaster)
mom-5 [plasma membrane]
(Caenorhabditis elegans)
FZD3 [plasma membrane]
(Bos taurus)
FZD3 [plasma membrane]
(Canis familiaris)
FZD3 [plasma membrane]
(Gallus gallus)
FZD3 [plasma membrane]
(Sus scrofa)
fzd3 [plasma membrane]
(Xenopus tropicalis)
Cross References
RefSeq
NP_665873.1
,
NP_059108.1
Guide to Pharmacology - Targets
231
OpenTargets
ENSG00000104290
GeneCards
Q9NPG1
HPA
ENSG00000104290-FZD3
Ensembl
ENSG00000104290
,
ENST00000240093
,
ENSP00000437489
,
ENST00000537916
,
ENSP00000240093
PRO
Q9NPG1
Pharos - Targets
Q9NPG1
HMDB Protein
HMDBP07699
PDB
8JHC
,
8JHI
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9HD64 XAGE1
0.527
2
UniProt:Q99679 GPR21
0.527
2
UniProt:O95498 VNN2
3
VNN2 [plasma membrane]
(R-HSA-2980905)
GPI-VNN2 [plasma membrane]
(R-HSA-8940753)
cleaved GPI-VNN2 [extracellular region]
(R-HSA-8941027)
0.527
2
UniProt:Q8IZF4 AGRG5
0.527
2
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